Regulation of senescence by microRNA biogenesis factors

Ageing Research Reviews

Volumn 11, Issue 4, 2012, Pages 491-500

  Abdelmohsen, Kotb ^a   Srikantan, Subramanya ^a   Kang, Min Ju ^a   Gorospe, Myriam ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Dicer; Drosha; Microprocessor; Precursor microRNA; Primary microRNA; RISC; Senescence

Indexed keywords

CYTOPLASM PROTEIN; MICRORNA; RIBONUCLEASE; RNA HELICASE; TRANSCRIPTION FACTOR;

BIOGENESIS; HUMAN; NONHUMAN; PROTEIN ANALYSIS; REVIEW; RNA EDITING; RNA PROCESSING; RNA SYNTHESIS; RNA TRANSCRIPTION; SENESCENCE;

ANIMALS; CELL AGING; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; RNA EDITING; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS;

EID: 84866516513     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2012.01.003     Document Type: Review

References (168)

1. Abdelmohsen K., Gorospe M. Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip. Rev. RNA 2010, 1:214-229.
2. Abdelmohsen K., Tominaga K., Lee E.K., Srikantan S., Kang M.J., et al. Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs. Nucleic Acids Res. 2011, 39:8513-8530.
3. Adams B.D., Claffey K.P., White B.A. Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells. Endocrinology 2009, 150:14-23.
4. Alexander K., Hinds P.W. Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence. Mol. Cell Biol. 2001, 21:3616-3631.
5. Asangani I.A., Rasheed S.A., Nikolova D.A., Leupold J.H., Colburn N.H., et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27:2128-2136.
6. Bachand F., Boisvert F.M., Cote J., Richard S., Autexier C. The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Mol. Biol. Cell 2002, 13:3192-3202.
7. Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., Kirkland J.L., van Deursen J.M. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236.
8. Battle D.J., Kasim M., Yong J., Lotti F., Lau C.K., Mouaikel J., Zhang Z., Han K., Wan L., Dreyfuss G. The SMN complex: an assembly machine for RNPs. Cold Spring Harb. Symp. Quant. Biol. 2006, 71:313-320.
9. Benkirane M., Neuveut C., Chun R.F., Smith S.M., Samuel C.E., Gatignol A., Jeang K.T. Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR. EMBO J. 1997, 16:611-624.
10. Bhattacharyya S.N., Habermacher R., Martine U., Closs E.I., Filipowicz W. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 2006, 125:1111-1124.
11. Blow M.J., Grocock R.J., van Dongen S., Enright A.J., Dicks E., Futreal P.A., Wooster R., Stratton M.R. RNA editing of human microRNAs. Genome Biol. 2006, 7:R27.
12. Bonifacio L.N., Jarstfer M.B. MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts. PLoS One 2010, 5:e12519.
13. Boominathan L. The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One 2010, 5:e10615.
14. Borchert G.M., Lanier W., Davidson B.L. RNA polymerase III transcribes human microRNAs. Nat. Struct. Mol. Biol. 2006, 13:1097-1101.
15. Borgdorff V., Lleonart M.E., Bishop C.L., Fessart D., Bergin A.H., Overhoff M.G., Beach D.H. Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1). Oncogene 2010, 29:2262-2271.
16. Bose C., Bhuvaneswaran C., Udupa K.B. Altered mitogen-activated protein kinase signal transduction in human skin fibroblasts during in vitro aging: differential expression of low-density lipoprotein receptor. J. Gerontol. A Biol. Sci. Med. Sci. 2004, 59:126-135.
17. Boyerinas B., Park S.M., Hau A., Murmann A.E., Peter M.E. The role of let-7 in cell differentiation and cancer. Endocr. Relat. Cancer 2010, 17:F19-F36.
18. Bracken C.P., Wall S.J., Barre B., Panov K.I., Ajuh P.M., Perkins N.D. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res. 2004, 68:7621-7628.
19. Briata P., Chen C.Y., Giovarelli M., Pasero M., Trabucchi M., Ramos A., Gherzi R. KSRP, many functions for a single protein. Front Biosci. 2011, 16:1787-1796.
20. Bruna A., Darken R.S., Rojo F., Ocana A., Penuelas S., et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 2007, 11:147-160.
21. Carmell M.A., Xuan Z., Zhang M.Q., Hannon G.J. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 2002, 16:2733-2742.
22. Carthew R.W., Sontheimer E.J. Origins and mechanisms of miRNAs and siRNAs. Cell 2009, 136:642-655.
23. Cenik E.S., Zamore P.D. Argonaute proteins. Curr. Biol. 2011, 21:R446-R449.
24. Chang T.C., Wentzel E.A., Kent O.A., Ramachandran K., Mullendore M., et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell. 2007, 26:745-752.
25. Chang T.C., Zeitels L.R., Hwang H.W., Chivukula R.R., Wentzel E.A., Dews M., Jung J., Gao P., Dang C.V., Beer M.A., et al. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:3384-3389.
26. Charlesworth B. Evolution of senescence: Alzheimer's disease and evolution. Curr. Biol. 1996, 6:20-22.
27. Cheloufi S., Dos Santos C.O., Chong M.M., Hannon G.J. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 2010, 465:584-589.
28. Chen C.X., Cho D.S., Wang Q., Lai F., Carter K.C., Nishikura K. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA 2000, 6:755-767.
29. Chendrimada T.P., Gregory R.I., Kumaraswamy E., Norman J., Cooch N., et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005, 436:740-744.
30. Cimmino A., Calin G.A., Fabbri M., Iorio M.V., Ferracin M., et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:13944-13949.
31. Collado M., Serrano M. Senescence in tumours: evidence from mice and humans. Nat. Rev. Cancer. 2010, 10:51-57.
32. Coppé J.P., Desprez P.Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 2010, 5:99-118.
33. Crescenzi E., Palumbo G., Brady H.J. Bcl-2 activates a programme of premature senescence in human carcinoma cells. Biochem. J. 2003, 375:263-274.
34. Darnell R.B. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip. Rev. RNA. 2010, 1:266-286.
35. Davis B.N., Hilyard A.C., Lagna G., Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008, 454:56-61.
36. DeGregori J., Johnson D.G. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr. Mol. Med. 2006, 6:739-748.
37. Di Leva G., Gasparini P., Piovan C., Ngankeu A., Garofalo M., Taccioli C., Iorio M.V., Li M., Volinia S., Alder H., Nakamura T., Nuovo G., Liu Y., Nephew K.P., Croce C.M. MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J. Natl. Cancer Inst. 2010, 102:706-721.
38. Dimova D.K., Dyson N.J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 2005, 24:2810-2826.
39. Dimri G.P., Hara E., Campisi J. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 1994, 269:16180-16186.
40. Dimri G.P., Itahana K., Acosta M., Campisi J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol. Cell Biol. 2000, 20:273-285.
41. Dötsch V., Bernassola F., Coutandin D., Candi E., Melino G. p63 and p73, the ancestors of p53. Cold Spring Harb. Perspect. Biol. 2010, 2:a004887.
42. Dupuis D.E., Maas S. MiRNA editing. Methods Mol. Biol. 2010, 667:267-279.
43. Edbauer D., Neilson J.R., Foster K.A., Wang C.F., Seeburg D.P., Batterton M.N., Tada T., Dolan B.M., Sharp P.A., Sheng M. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 2010, 65:373-384.
44. Eisenberg E., Adamsky K., Cohen L., Amariglio N., Hirshberg A., et al. Identification of RNA editing sites in the SNP database. Nucleic Acids Res. 2005, 33:4612-4617.
45. Emmrich S., Pützer B.M. Checks and balances: E2F-microRNA crosstalk in cancer control. Cell Cycle 2010, 9:2555-2567.
46. Faraonio R., Salerno P., Passaro F., Sedia C., Iaccio A., et al. A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. Cell Death Differ. 2011, (Epub ahead of print).
47. Feliciano A., Sanchez-Sendra B., Kondoh H., Lleonart M.E. MicroRNAs regulate key effector pathways of senescence. J. Aging Res. 2011, 2011:205378.
48. Forstemann K., Horwich M.D., Wee L., Tomari Y., Zamore P.D. Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell 2007, 130:287-297.
49. Fukuda T., Yamagata K., Fujiyama S., Matsumoto T., Koshida I., et al. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat. Cell Biol. 2007, 9:604-611.
50. Fujii M., Lyakh L.A., Bracken C.P., Fukuoka J., Hayakawa M., et al. SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Mol. Cell 2006, 24:771-783.
51. Fuller-Pace F.V., Moore H.C. RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development. Future Oncol. 2011, 7:239-251.
52. Galardi S., Mercatelli N., Giorda E., Massalini S., Frajese G.V., Ciafrè S.A., Farace M.G. miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J. Biol. Chem. 2007, 282:23716-23724.
53. Gherzi R., Chen C.Y., Trabucchi M., Ramos A., Briata P. The role of KSRP in mRNA decay and microRNA precursor maturation. Wiley Interdiscip. Rev. RNA 2010, 1:230-239.
54. Glorian V., Maillot G., Poles S., Iacovoni J.S., Favre G., Vagner S. HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis. Cell Death Differ. 2011, 18:1692-1701.
55. Golde T.E., Miller V.M. Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases. Alzheimers Res. Ther. 2009, 1:5.
56. Good L., Dimri G.P., Campisi J., Chen K.Y. Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J. Cell Physiol. 1996, 168:580-588.
57. Gorospe M., Abdelmohsen K. MicroRegulators come of age in senescence. Trends Genet. 2011, 27:233-241.
58. Guan D., Altan-Bonnet N., Parrott A.M., Arrigo C.J., Li Q., et al. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. Mol. Cell Biol. 2008, 28:4629-4641.
59. Guil S., Caceres J.F. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat. Struct. Mol. Biol. 2007, 14:591-596.
60. Hackl M., Brunner S., Fortschegger K., Schreiner C., Micutkova L., Mück C., Laschober G.T., Lepperdinger G., Sampson N., Berger P., Herndler-Brandstetter D., Wieser M., Kühnel H., Strasser A., Rinnerthaler M., Breitenbach M., Mildner M., Eckhart L., Tschachler E., Trost A., Bauer J.W., Papak C., Trajanoski Z., Scheideler M., Grillari-Voglauer R., Grubeck-Loebenstein B., Jansen-Dürr P., Grillari J. miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell. 2010, 9:291-296.
61. Hafner M., Landthaler M., Burger L., Khorshid M., Hausser J., Berninger P., Rothballer A., Ascano M., Jungkamp A.C., Munschauer M., Ulrich A., Wardle G.S., Dewell S., Zavolan M., Tuschl T. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 2010, 141:129-141.
62. Han J., Pedersen J.S., Kwon S.C., Belair C.D., Kim Y.K., Yeom K.H., Yang W.Y., Haussler D., Blelloch R., Kim V.N. Posttranscriptional crossregulation between Drosha and DGCR8. Cell 2009, 136:75-84.
63. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 1965, 37:614-636.
64. Heo I., Joo C., Kim Y.K., Ha M., Yoon M.J., Cho J., Yeom K.H., Han J., Kim V.N. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 2009, 138:696-708.
65. Heo I., Kim V.N. Regulating the regulators: posttranslational modifications of RNA silencing factors. Cell 2009, 139:28-31.
66. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010, 17:193-199.
67. Hong L., Lai M., Chen M., Xie C., Liao R., Kang Y.J., Xiao C., Hu W.Y., Han J., Sun P. The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res. 2010, 70:8547-8557.
68. Hydbring P., Larsson L.G. Tipping the balance: Cdk2 enables Myc to suppress senescence. Cancer Res. 2010, 70:6687-6691.
69. Ikeyama S., Kokkonen G., Martindale J.L., Wang X.T., Gorospe M., Holbrook N.J. Effects of aging and calorie restriction of Fischer 344 rats on hepatocellular response to proliferative signals. Exp. Gerontol. 2003, 38:431-439.
70. Itahana K., Dimri G., Campisi J. Regulation of cellular senescence by p53. Eur. J. Biochem. 2001, 268:2784-2791.
71. Jaskiewicz L., Filipowicz W. Role of Dicer in posttranscriptional RNA silencing. Curr. Top. Microbiol. Immunol. 2008, 320:77-97.
72. Jin P., Zarnescu D.C., Ceman S., Nakamoto M., Mowrey J., Jongens T.A., Nelson D.L., Moses K., Warren S.T. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat. Neurosci. 2004, 7:113-117.
73. Kaller M., Liffers S.T., Oeljeklaus S., Kuhlmann K., Röh S., Hoffmann R., Warscheid B., Hermeking H. Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol. Cell Proteomics 2011, 10:M111.
74. Kawahara Y., Megraw M., Kreider E., Iizasa H., Valente L., Hatzigeorgiou A.G., Nishikura K. Frequency and fate of microRNA editing in human brain. Nucleic Acids Res. 2008, 36:5270-5280.
75. Kedde M., van Kouwenhove M., Zwart W., Oude Vrielink J.A., Elkon R., Agami R. A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. Nat. Cell Biol. 2010, 12:1014-1020.
76. Keene J.D., Komisarow J.M., Friedersdorf M.B. RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts. Nat. Protoc. 2006, 1:302-307.
77. Kim H.H., Kuwano Y., Srikantan S., Lee E.K., Martindale J.L., Gorospe M. HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev. 2009, 23:1743-1748.
78. Kim V.N., Han J., Siomi M.C. Biogenesis of small RNAs in animals. Nat. Rev. Mol. Cell Biol. 2009, 10:126-139.
79. Kim B.S., Jung J.S., Jang J.H., Kang K.S. Kang SK. Nuclear Argonaute 2 regulates adipose tissue-derived stem cell survival through direct control of miR10b and selenoprotein N1 expression. Aging Cell. 2011, 10:277-291.
80. Kim D.D., Kim T.T., Walsh T., Kobayashi Y., Matise T.C., et al. Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004, 14:1719-1725.
81. Kim K.H., Park G.T., Lim Y.B., Rue S.W., Jung J.C., et al. Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Biochem. Biophys. Res. Commun. 2004, 318:819-825.
82. Kimura S., Naganuma S., Susuki D., Hirono Y., Yamaguchi A., Fujieda S., Sano K., Itoh H. Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC. Oncol. Rep. 2010, 23:1625-1633.
83. King C.E., Cuatrecasas M., Castells A., Sepulveda A.R., Lee J.S., Rustgi A.K. LIN28B promotes colon cancer progression and metastasis. Cancer Res. 2011, 71:4260-4268.
84. Knouf E.C., Garg K., Arroyo J.D., Correa Y., Sarkar D., Parkin R.K., Wurz K., O'Briant K.C., Godwin A.K., Urban N.D., Ruzzo W.L., Gentleman R., Drescher C.W., Swisher E.M., Tewari M An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription. Nucleic Acids Res. 2011, [Epub ahead of print].
85. Krol J., Loedige I., Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 2010, 11:597-610.
86. Kuilman T., Michaloglou C., Mooi W.J., Peeper D.S. The essence of senescence. Genes Dev. 2010, 24:2463-2479.
87. Kumamoto K., Spillare E.A., Fujita K., Horikawa I., Yamashita T., et al. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res. 2008, 68:3193-3203.
88. Kuwano Y., Pullmann R., Marasa B.S., Abdelmohsen K., Lee E.K., Yang X., Martindale J.L., Zhan M., Gorospe M. NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res. 2010, 38:225-238.
89. Larsson L.G.S.N.I.P1. Myc's new helper in transcriptional activation. Mol. Cell 2006, 24:811-812.
90. Lee Y.S., Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 2007, 21:1025-1030.
91. Legesse-Miller A., Elemento O., Pfau S.J., Forman J.J., Tavazoie S. Coller HA. let-7 overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. J. Biol. Chem. 2009, 284:6605-6609.
92. Li G., Luna C., Qiu J., Epstein D.L., Gonzalez P. Alterations in microRNA expression in stress-induced cellular senescence. Mech. Ageing Dev. 2009, 130:731-741.
93. Liu J., Carmell M.A., Rivas F.V., Marsden C.G., Thomson J.M., et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 2004, 305:1437-1441.
94. Luciano D.J., Mirsky H., Vendetti N.J., Maas S. RNA editing of a miRNA precursor. RNA 2004, 10:1174-1177.
95. Maier B., Gluba W., Bernier B., Turner T., Mohammad K., Guise T., Sutherland A., Thorner M., Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 2004, 18:306-319.
96. Magenta A., Cencioni C., Fasanaro P., Zaccagnini G., Greco S., Sarra-Ferraris G., Antonini A., Martelli F., Capogrossi M.C. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ. 2011, 18:1628-1639.
97. Marasa B.S., Srikantan S., Martindale J.L., Kim M.M., Lee E.K., Gorospe M., Abdelmohsen K. MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging 2010, 2:333-343.
98. Marasa B.S., Srikantan S., Masuda K., Abdelmohsen K., Kuwano Y., Yang X., Martindale J.L., Rinker-Schaeffer C.W., Increased Gorospe M. MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal. 2009, 2. ra69.
99. Massague J., Seoane J., Wotton D. Smad transcription factors. Genes Dev. 2005, 19:2783-2810.
100. Masuda K., Rokutan K., General R.B.P. Expression in human tissues as a function of age. Ageing Res Rev. 2012, 11:423-431.
101. Mehler M.F. Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog. Neurobiol. 2008, 86:305-341.
102. Michlewski G., Cáceres J.F. Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat. Struct. Mol. Biol. 2010, 17:1011-1018.
103. Melo S.A., Esteller M. Dysregulation of microRNAs in cancer: playing with fire. FEBS Lett. 2011, 585:2087-2099.
104. Melo S.A., Ropero S., Moutinho C., Aaltonen L.A., Yamamoto H., et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat. Genet. 2009, 41:365-370.
105. Mongelard F., Bouvet P. Nucleolin: a multiFACeTed protein. Trends Cell Biol. 2007, 17:80-86.
106. Montano M., Long K. RNA surveillance-an emerging role for RNA regulatory networks in aging. Ageing Res. Rev. 2011, 10:216-224.
107. Morita S., Horii T., Kimura M., Goto Y., Ochiya T., Hatada I. One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics 2007, 89:687-696.
108. Mourelatos Z., Dostie J., Paushkin S., Sharma A., Charroux B., et al. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 2002, 16:720-728.
109. Mudhasani R., Zhu Z., Hutvagner G., Eischen C.M., Lyle S., et al. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J. Cell Biol. 2008, 181:1055-1063.
110. Nardella C., Clohessy J.G., Alimonti A., Pandolfi P.P. Pro-senescence therapy for cancer treatment. Nat. Rev. Cancer 2011, 11:503-511.
111. Narita M. Senescence comes of age. Nat. Med. 2005, 11:920-922.
112. Newman M.A., Hammond S.M. Emerging paradigms of regulated microRNA processing. Genes Dev. 2010, 24:1086-1092.
113. Nohata N., Sone Y., Hanazawa T., Fuse M., Kikkawa N., Yoshino H., Chiyomaru T., Kawakami K., Enokida H., Nakagawa M., Shozu M., Okamoto Y. Seki N. miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma. Oncotarget. 2011, 2:29-42.
114. Noren Hooten N., Abdelmohsen K., Gorospe M., Ejiogu N., Zonderman A.B., Evans M.K. microRNA expression patterns reveal differential expression of target genes with age. PLoS One 2010, 5:e10724.
115. O'Donnell K.A., Wentzel E.A., Zeller K.I., Dang C.V., Mendell J.T. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005, 435:839-843.
116. Paroo Z., Ye X., Chen S., Liu Q. Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell 2009, 139:112-122.
117. Pickering B.F., Yu D., Van Dyke M.W. Nucleolin interacts with the microprocessor complex to affect microRNAs 15a and 16 biogenesis. J. Biol. Chem. 2011, (Epub ahead of print).
118. Polager S., Ginsberg D. E2F-at the crossroads of life and death. Trends Cell Biol. 2008, 18:528-535.
119. Pulikkan J.A., Dengler V., Peramangalam P.S., Peer Zada A.A., Müller-Tidow C., Bohlander S.K., Tenen D.G., Behre G. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood 2010, 115:1768-1778.
120. Pulikkan J.A., Peramangalam P.S., Dengler V., Ho P.A., Preudhomme C., Meshinchi S., Christopeit M., Nibourel O., Müller-Tidow C., Bohlander S.K., Tenen D.G., Behre G. C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood 2010, 116:5638-5649.
121. Raina A.K., Pardo P., Rottkamp C.A., Zhu X., Pereira-Smith O.M., Smith M.A. Neurons in Alzheimer disease emerge from senescence. Mech. Ageing Dev. 2001, 123:3-9.
122. Rizzo M., Mariani L., Pitto L., Rainaldi G., Simili M. miR-20a and miR-290, multi-faceted players with a role in tumourigenesis and senescence. J. Cell Mol. Med. 2010, 14:2633-2640.
123. Roche K.C., Wiechens N., Owen-Hughes T., Perkins N.D. The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression. Oncogene 2004, 23:8185-8195.
124. Rodier F., Campisi J. Four faces of cellular senescence. J. Cell Biol. 2011, 192:547-556.
125. Sakamoto S., Aoki K., Higuchi T., Todaka H., Morisawa K., et al. The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway. Mol. Cell Biol. 2009, 29:3754-3769.
126. Salzman D.W., Shubert-Coleman J., Furneaux H. P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression. J. Biol. Chem. 2007, 282:32773-32779.
127. Santarosa M., Del Col L., Tonin E., Caragnano A., Viel A., Maestro R. Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers. Mol. Cancer Ther. 2009, 8:844-854.
128. Schubert J., Brabletz T. p53 Spreads out further: suppression of EMT and stemness by activating miR-200c expression. Cell Res. 2011, 21:705-707.
129. Shamanna R.A., Hoque M., Lewis-Antes A., Azzam E.I., Lagunoff D., et al. The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. Mol. Cell Biol. 2011, 31:4832-4843.
130. Shatseva T., Lee D.Y., Deng Z., Yang B.B. MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. J. Cell Sci. 2011, 124:2826-2836.
131. Shimada N., Rios I., Moran H., Sayers B. Hubbard K. p38 MAP kinase-dependent regulation of the expression level and subcellular distribution of heterogeneous nuclear ribonucleoprotein A1 and its involvement in cellular senescence in normal human fibroblasts. RNA Biol. 2009, 6:293-304.
132. Singh R., George J., Shukla Y. Role of senescence and mitotic catastrophe in cancer therapy. Cell Div. 2010, 5:4.
133. Siomi H., Siomi M.C. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell. 2010, 38:323-332.
134. Sokol D.K., Maloney B., Long J.M., Ray B., Lahiri D.K. Autism Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links. Neurology 2011, 76:1344-1352.
135. Soliman M.A., Riabowol K. After a decade of study-ING, a PHD for a versatile family of proteins. Trends Biochem. Sci. 2007, 32:509-519.
136. Srikantan S., Gorospe M. HuR function in disease. Front Biosci. 2012, 17:189-205.
137. Srikantan, S., Tominaga, K., Gorospe, M., 2012. Functional interplay between RNA-binding protein HuR and microRNAs. Curr. Protein Pept. Sci., in press.
138. Srikantan S., Abdelmohsen K., Lee E.K., Tominaga K., Subaran S.S., Kuwano Y., Kulshrestha R., Panchakshari R., Kim H.H., Yang X., Martindale J.L., Marasa B.S., Kim M.M., Wersto R.P., Indig F.E., Chowdhury D., Gorospe M. Translational control of TOP2A influences doxorubicin efficacy. Mol. Cell Biol. 2011, 31:3790-3801.
139. Su X., Chakravarti D., Cho M.S., Liu L., Gi Y.J., et al. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 2010, 467:986-990.
140. Sun W., Shen W., Yang S., Hu F., Li H., Zhu T.H. miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBPβ. Cell Res. 2010, 20:1158-1169.
141. Sylvestre Y., De Guire V., Querido E., Mukhopadhyay U.K., Bourdeau V., et al. An E2F/miR-20a autoregulatory feedback loop. J. Biol. Chem. 2007, 282. 2135-2134.
142. Takakura S., Mitsutake N., Nakashima M., Namba H., Saenko V.A., et al. Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells. Cancer Sci. 2008, 99:1147-1154.
143. Tazawa H., Tsuchiya N., Izumiya M., Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:15472-15477.
144. Terao M., Fratelli M., Kurosaki M., Zanetti A., Guarnaccia V., Paroni G., Tsykin A., Lupi M., Gianni M., Goodall G.J., Garattini E. Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets. J. Biol. Chem. 2011, 286:4027-4042.
145. Tombor B., Rundell K., Oltvai Z.N. Bcl-2 promotes premature senescence induced by oncogenic Ras. Biochem. Biophys. Res. Commun. 2003, 303:800-807.
146. Tominaga K., Srikantan S., Lee E.K., Subaran S.S., Martindale J.L., et al. Competitive regulation of nucleolin expression by HuR and miR-494. Mol. Cell Biol. 2011, 31:4219-4231.
147. Trabucchi M., Briata P., Garcia-Mayoral M., Haase A.D., Filipowicz W., Ramos A., Gherzi R., Rosenfeld M.G. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 2009, 459:1010-1014.
148. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002, 415:45-53.
149. Tzatsos A., Paskaleva P., Lymperi S., Contino G., Stoykova S., Chen Z., Wong K.K., Bardeesy N. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J. Biol. Chem. 2011, 286:33061-33069.
150. van Almen G.C., Verhesen W., van Leeuwen R.E., van de Vrie M., Eurlings C., Schellings M.W., Swinnen M., Cleutjens J.P., van Zandvoort M.A., Heymans S., Schroen B. MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell. 2011, 10:769-779.
151. van Kouwenhove M., Kedde M., Agami R. MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat. Rev. Cancer 2011, 11:644-656.
152. Van Wynsberghe P.M., Kai Z.S., Massirer K.B., Burton V.H., Yeo G.W., Pasquinelli A.E. LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat. Struct. Mol. Biol. 2011, 18:302-308.
153. Varela I., Cadiñanos J., Pendás A.M., Gutiérrez-Fernández A., Folgueras A.R., Sánchez L.M., Zhou Z., Rodríguez F.J., Stewart C.L., Vega J.A., et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 2005, 437:564-568.
154. Vasudevan S., Tong Y., Steitz J.A. Switching from repression to activation: microRNAs can up-regulate translation. Science 2007, 318:1931-1934.
155. Viswanathan S.R., Daley G.Q. Lin28. A microRNA regulator with a macro role. Cell 2010, 140:445-449.
156. Wang W. Regulatory RNA-binding proteins in senescence. Ageing Res. Rev. 2012, 11:485-490.
157. Wang Y., Medvid R., Melton C., Jaenisch R., Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 2007, 39:380-385.
158. Wang W., Yang X., Cristofalo V.J., Holbrook N.J., Gorospe M. Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol. Cell Biol. 2001, 21:5889-5898.
159. Winter J., Jung S., Keller S., Gregory R.I., Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 2009, 11:228-234.
160. Woods K., Thomson J.M., Hammond S.M. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J. Biol. Chem. 2007, 282:2130-2134.
161. Wu H., Sun S., Tu K., Gao Y., Xie B., Krainer A.R., Zhu J. A splicing-independent function of SF2/ASF in microRNA processing. Mol. Cell 2010, 38:67-77.
162. Xu D., Takeshita F., Hino Y., Fukunaga S., Kudo Y., Tamaki A., Matsunaga J., Takahashi R.U., Takata T., Shimamoto A., Ochiya T., Tahara H. miR-22 represses cancer progression by inducing cellular senescence. J. Cell Biol. 2011, 193:409-424.
163. Xue D., Peng Y., Wang F., Allan R.W., Cao D. RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours. Histopathology 2011, 59:452-459.
164. Yang W., Chendrimada T.P., Wang Q., Higuchi M., Seeburg P.H., et al. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat. Struct. Mol. Biol. 2006, 13:13-21.
165. Yang X., Feng M., Jiang X., Wu Z., Li Z., et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 2009, 23:2388-2393.
166. Yang X., Lin X., Zhong X., Kaur S., Li N., Liang S., Lassus H., Wang L., Katsaros D., Montone K., Zhao X., Zhang Y., Bützow R., Coukos G., Zhang L. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010, 70:9463-9472.
167. Yu B., Bi L., Zheng B., Ji L., Chevalier D., et al. The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10073-10078.
168. Zhu D., Xu G., Ghandhi S., Hubbard K. Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence. J. Cell Physiol. 2002, 193:19-25.