An amphibian model for studies of developmental reproductive toxicity

Methods in Molecular Biology

Volumn 889, Issue , 2012, Pages 73-83

  Berg, Cecilia ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Amphibians; Aromatase; Endocrine disruption; Fertility; Gametogenesis; M llerian ducts; Oviducts; Reproduction; Sex differentiation; Thyroid

Indexed keywords

AROMATASE; ENDOCRINE DISRUPTOR; ESTROGEN; THYROXINE; AMPHIBIAN PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL HUSBANDRY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; ESTROGEN SYNTHESIS; FEMALE; FEMALE GENITAL SYSTEM; FERTILITY; GAMETOGENESIS; GENITAL SYSTEM; GONAD DEVELOPMENT; HISTOLOGY; MALE; MALE GENITAL SYSTEM; METAMORPHOSIS; MORPHOMETRICS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SEX DETERMINATION; SEX DIFFERENTIATION; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; STUDY DESIGN; TADPOLE; THYROID GLAND; TISSUE FIXATION; XENOPUS LAEVIS; XENOPUS TROPICALIS; ANIMAL; BRAIN; CHEMISTRY; DISEASE MODEL; DISSECTION; DRUG EFFECT; ENZYMOLOGY; GONAD; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY; TOXICITY TESTING; XENOPUS;

AMPHIBIAN PROTEINS; ANIMAL HUSBANDRY; ANIMALS; AROMATASE; BRAIN; DISEASE MODELS, ANIMAL; DISSECTION; ENDOCRINE DISRUPTORS; ENZYME ASSAYS; FEMALE; FERTILITY; GONADS; MALE; METAMORPHOSIS, BIOLOGICAL; RESEARCH DESIGN; SEX DIFFERENTIATION; SPERM COUNT; SPERM MOTILITY; THYROID GLAND; TOXICITY TESTS; XENOPUS;

EID: 84866512393     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-867-2_6     Document Type: Article

References (15)

1. Berg C, Gyllenhammar I, Kvarnryd M (2009) Xenopus tropicalis as a test system for developmental and reproductive toxicity. J Toxicol Environ Health 72:219-225
2. Kloas W, Lutz I (2006) Amphibians as model to study endocrine disrupters. J Chromatogr A 1130:16-27
3. Pettersson I, Arukwe A, Lundstedt-Enkel K, Mortensen AS, Berg C (2006) Persistent sex-reversal and oviducal agenesis in adult Xenopus (Silurana) tropicalis frogs following larval exposure to the environmental pollutant ethynylestradiol. Aquat Toxicol 79:356-365
4. Pettersson I, Berg C (2007) Environmentally relevant concentrations of ethynylestradiol cause female-biased sex ratios in Xenopus tropicalis and Rana temporaria. Environ Toxicol Chem 26:1005-1009
5. Gyllenhammar I, Eriksson H, Söderqvist A, Lindberg R, Fick J, Berg C (2009) Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs. Aquat Toxicol 91:102-109
6. Gyllenhammar I, Holm L, Eklund R, Berg C (2009) Reproductive toxicity in Xenopus tropi-calis after developmental exposure to environmental concentrations of ethynylestradiol. Aquat Toxicol 91:171-178
7. Kvarnryd M, Grabic R, Brandt I, Berg C (2011) Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs. Aquat Toxicol 103:18-24
8. Hirsch N, Zimmerman LB et al (2002) Xenopus, the next generation: X. tropicalis genetics and genomics. Dev Dyn 225:422-433
9. Berg C, Backström T, Winberg S, Lindberg R, Fick J, Brandt I (2009) Developmental exposure to fluoxetine and ethynylestradiol modulates neurotransmitter levels in speci fic brain regions of Xenopus tropicalis frogs. Abstract at the annual meeting of society of environmental toxicity and chemistry, Sweden
10. Jönsson M, Berg C, Goldstone J, Stegeman J (2011) New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183
11. Nieuwkoop PD, Faber J (1956) Normal table of Xenopus laevis (Daudin). North Holland Publishing, Amsterdam
12. Hausen P, Riebesell M (1991) The early development of Xenopus laevis, an atlas of the histology. Verlag der Zeitschrift für Naurforschung, Germany
13. Kalt MR (1976) Morphology and kinetics of spermatogenesis in Xenopus laevis. J Exp Zool 195:393-407
14. Lephart ED, Simpson ER (1991) Assay of aromatase activity. Methods Enzymol 206: 477-483
15. Hutchinson TH, Shillabeer N et al (2006) Acute and chronic effects of carrier solvents in aquatic organisms: a critical review. Aquat Toxicol 76:69-92