Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a protein kinase

Journal of the American Chemical Society

Volumn 134, Issue 37, 2012, Pages 15357-15370

  Jacobsen, Douglas M ^a   Bao, Zhao Qin ^a   Obrien, Patrick ^a   Brooks, Charles L ^b   Young, Matthew A ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ATP BINDING; CHEMICAL TRANSITION STATE; CYCLIN-DEPENDENT KINASE; DIVALENT CATION; DIVALENT METAL ION; ESSENTIAL METALS; KINETIC ANALYSIS; MAGNESIUM IONS; MOLECULAR DYNAMICS SIMULATIONS; MUTATIONAL EFFECTS; OVERALL RATE; PHOSPHATE GROUP; PHOSPHATE MOBILITY; PHOSPHORYL TRANSFER; PRODUCT RELEASE; PROTEIN KINASE; RATE LIMITING; REGULATORY FACTORS; STRUCTURAL SIMILARITY; TRANSITION STATE;

CATALYSIS; METAL IONS; MOLECULAR DYNAMICS; PROTEINS;

ENZYMES;

ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE 2; MAGNESIUM ION; PHOSPHATE; PHOSPHORYLASE; PROTEIN KINASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STABILITY; HUMAN; KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN BINDING;

CALORIMETRY; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MAGNESIUM; METALS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN KINASES; STATIC ELECTRICITY;

EID: 84866507956     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja304419t     Document Type: Article

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