Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the PI3K/Akt pathway

International Journal of Molecular Medicine

Volumn 30, Issue 4, 2012, Pages 791-796

  Chen, Azhen ^a   Lin, Zhicheng ^a   Lan, Lan ^a   Xie, Guanli ^a   Huang, Jia ^a   Lin, Jiumao ^a   Peng, Jun ^a   Tao, Jing ^a   Chen, Lidian ^a  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Cerebral ischemia reperfusion; Electroacupuncture; PI3K Akt pathway; Quchi (LI11) acupoints; Zusanli (ST36)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; ELECTROACUPUNCTURE; IN VIVO STUDY; MALE; MOLECULAR MECHANICS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ACUPUNCTURE POINTS; ANIMALS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; ELECTROACUPUNCTURE; MALE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84866501443     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1074     Document Type: Article

References (22)

1. Feigin VL: Stroke epidemiology in the developing world. Lancet 365: 2160-2161, 2005.
2. Donnan GA, Fisher M, Macleod M and Davis SM: Stroke. Lancet 37: 1612-1623, 2008. (Pubitemid 351626845)
3. Wu JN: A short history of acupuncture. J Altern Complement Med 2: 19-21, 1996.
4. Hu HH, Chung C, Liu T, et al: A randomized controlled trial on the treatment for acute partial ischemic stroke with acupuncture. Neuroepidemiology 12: 106-113, 1993. (Pubitemid 23300782)
5. Jansen G, Lundeberg T, Kjartansson J and Samuelson U: Acupuncture and sensory neuropeptides increase cutaneous blood flow in rats. Neurosci Lett 97: 305-309, 1989. (Pubitemid 19047476)
6. Johansson K, Lindgren I, Widner H, Wiklund I and Johansson B: Can sensory stimulation improve the functional outcome in stroke patients? Neurology 43: 2189-2189, 1993.
7. Magnusson M, Johansson K and Johansson BB: Sensory stimulation promotes normalization of postural control after stroke. Stroke 25: 1176-1180, 1994. (Pubitemid 24164757)
8. Tao J, Xue XH, Chen LD, et al: Electroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem cells in rats with focal cerebral ischemia. Neurol Res 32: 198-204, 2010.
9. Brazil DP, Yang ZZ and Hemmings BA: Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29: 233-242, 2004. (Pubitemid 38591317)
10. Franke TF, Kaplan DR, Cantley LC and Toker A: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate. Science 275: 665-668, 1997. (Pubitemid 27061333)
11. Janelidze S, Hu BR, Siesjö P and Siesjö BK: Alterations of Akt1 (PKBalpha) and p70(S6K) in transient focal ischemia. Neurobiol Dis 8: 147-154, 2001. (Pubitemid 32171826)
12. Noshita N, Lewén A, Sugawara T and Chan PH: Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21: 1442-1450, 2001. (Pubitemid 33120944)
13. Shibata M, Yamawaki T, Sasaki T, et al: Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice. Brain Res 942: 1-10, 2002. (Pubitemid 34597063)
14. Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989. (Pubitemid 19040218)
15. Lu C, Liu L, Chen Y, et al: TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. J Immunol 187: 1458-1466, 2011.
16. Produit-Zengaffinen N, Pournaras CJ and Schorderet DF: Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. Mol Vis 15: 2101-2110, 2009.
17. Xi H, Zhang T, Tao T, et al: Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. Brain Res 1410: 24-32, 2011.
18. Gao X, Zhang H, Steinberg G and Zhao H: The Akt pathway is involved in rapid ischemic tolerance in focal ischemia in rats. Transl Stroke Res 1: 202-209, 2010.
19. Taylor JM, Ali U, Iannello RC, Hertzog P and Crack PJ: Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J Neurochem 92: 283-293, 2005. (Pubitemid 40194019)
20. Baba T, Kameda M, Yasuhara T, et al: Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/Akt signaling pathway. Stroke 40: e598-e605, 2009.
21. Chen B, Gao XQ, Yang CX, et al: Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats. Brain Res 1284: 1-11, 2009.
22. Genovese T, Mazzon E, Paterniti I, Esposito E and Cuzzocrea S: Neuroprotective effects of olprinone after cerebral ischemia/reperfusion injury in rats. Neurosci Lett 503: 93-99, 2011.