메뉴 건너뛰기




Volumn 4, Issue , 2011, Pages 223-231

Diclofenac sodium topical solution with dimethyl sulfoxide, a viable alternative to oral nonsteroidal anti-inflammatories in osteoarthritis: Review of current evidence

Author keywords

Diclofenac; Nonsteroidal anti inflammatory drugs; Osteoarthritis; Topical analgesic

Indexed keywords


EID: 84866500859     PISSN: None     EISSN: 11782390     Source Type: Journal    
DOI: 10.2147/JMDH.S23209     Document Type: Article
Times cited : (17)

References (46)
  • 1
    • 38149052992 scopus 로고    scopus 로고
    • National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    • Lawrence RC, Felson DT, Helmick CG, et al. National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008; 58(1):26–35.
    • (2008) Arthritis Rheum , vol.58 , Issue.1 , pp. 26-35
    • Lawrence, R.C.1    Felson, D.T.2    Helmick, C.G.3
  • 2
    • 73449123799 scopus 로고    scopus 로고
    • The economic burden of osteoarthritis
    • Bitton R. The economic burden of osteoarthritis. Am J Manag Care. 2009;15(Suppl 8):S230–S235.
    • (2009) Am J Manag Care , vol.15 , pp. S230-S235
    • Bitton, R.1
  • 3
    • 0033710649 scopus 로고    scopus 로고
    • Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update
    • American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum. 2000;43(9):1905–1915.
    • (2000) Arthritis Rheum , vol.43 , Issue.9 , pp. 1905-1915
  • 4
    • 10744224265 scopus 로고    scopus 로고
    • Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT. EULAR Recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
    • Jordan KM, Arden NK, Doherty M, et al. Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003;62(12):1145–1155.
    • (2003) Ann Rheum Dis , vol.62 , Issue.12 , pp. 1145-1155
    • Jordan, K.M.1    Arden, N.K.2    Doherty, M.3
  • 5
    • 38949130488 scopus 로고    scopus 로고
    • OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
    • Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137–162.
    • (2008) Osteoarthritis Cartilage , vol.16 , Issue.2 , pp. 137-162
    • Zhang, W.1    Moskowitz, R.W.2    Nuki, G.3
  • 6
    • 30144438737 scopus 로고    scopus 로고
    • Third Canadian Consensus Conference Group. An evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference
    • Tannenbaum H, Bombardier C, Davis P, Russell AS. Third Canadian Consensus Conference Group. An evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference. J Rheumatol. 2006;33(1):140–157.
    • (2006) J Rheumatol , vol.33 , Issue.1 , pp. 140-157
    • Tannenbaum, H.1    Bombardier, C.2    Davis, P.3    Russell, A.S.4
  • 7
    • 34547696965 scopus 로고    scopus 로고
    • Comparative Effectiveness Review No. 4. Rockville, MD: agency for Healthcare Research and Quality; September 2006. Available from, Accessed May 5
    • Chou R, Helfand M, Peterson K, Dana T, Roberts C. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis. Comparative Effectiveness Review No. 4. Rockville, MD: agency for Healthcare Research and Quality; September 2006. Available from: http://www. effectivehealthcare.ahrq.gov/reports/final.cfm. Accessed May 5, 2010.
    • (2010) Comparative Effectiveness and Safety of Analgesics for Osteoarthritis
    • Chou, R.1    Helfand, M.2    Peterson, K.3    Dana, T.4    Roberts, C.5
  • 8
    • 84908458896 scopus 로고    scopus 로고
    • London, UK: Royal College of Physicians; 2008. Available from, Accessed May 5
    • National Collaborating Centre for Chronic Conditions. Osteoarthritis: National Clinical Guideline for Care and Management in Adults. London, UK: Royal College of Physicians; 2008. Available from: http://www.nice. org.uk/nicemedia/pdf/cg059fullguideline.pdf. Accessed May 5, 2010.
    • (2010) Osteoarthritis: National Clinical Guideline for Care and Management in Adults
  • 9
    • 22244475383 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drug gastropathy: We started it, why don’t we stop it?
    • Roth SH. Nonsteroidal antiinflammatory drug gastropathy: we started it, why don’t we stop it? J Rheum. 2005;32(7):1189–1191.
    • (2005) J Rheum , vol.32 , Issue.7 , pp. 1189-1191
    • Roth, S.H.1
  • 10
    • 34247464709 scopus 로고    scopus 로고
    • American Heart Association. Use of nonsteroidal antiinflammatory drugs: An update for clinicians: A scientific statement from the American Heart Association
    • Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA. American Heart Association. Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007;115(12):1634–1642.
    • (2007) Circulation , vol.115 , Issue.12 , pp. 1634-1642
    • Antman, E.M.1    Bennett, J.S.2    Daugherty, A.3    Furberg, C.4    Roberts, H.5    Taubert, K.A.6
  • 11
    • 28544433318 scopus 로고    scopus 로고
    • Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: Population based nested case-control analysis
    • Hippisley-Cox J, Coupland C, Logan R. Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ. 2005;331(7528):1310–1316.
    • (2005) BMJ , vol.331 , Issue.7528 , pp. 1310-1316
    • Hippisley-Cox, J.1    Coupland, C.2    Logan, R.3
  • 12
    • 33744976771 scopus 로고    scopus 로고
    • Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Metaanalysis of randomised trials
    • Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Metaanalysis of randomised trials. BMJ. 2006;332(7553):1302–1308.
    • (2006) BMJ , vol.332 , Issue.7553 , pp. 1302-1308
    • Kearney, P.M.1    Baigent, C.2    Godwin, J.3    Halls, H.4    Emberson, J.R.5    Patrono, C.6
  • 13
    • 2542447680 scopus 로고    scopus 로고
    • Gastrointestinal bleeding after the introduction of COX 2 inhibitors: Ecological study
    • Mamdani M, Juurlink DN, Kopp A, Naglie G, Austin PC, Laupacis A. Gastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological study. BMJ. 2004;328(7453):1415–1416.
    • (2004) BMJ , vol.328 , Issue.7453 , pp. 1415-1416
    • Mamdani, M.1    Juurlink, D.N.2    Kopp, A.3    Naglie, G.4    Austin, P.C.5    Laupacis, A.6
  • 14
    • 34548329694 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: Balancing gastrointestinal and cardiovascular risk
    • Moore RA, Derry S, McQuay HJ. Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk. BMC Musculoskelet Disord. 2007;8:73.
    • (2007) BMC Musculoskelet Disord , vol.8 , pp. 73
    • Moore, R.A.1    Derry, S.2    McQuay, H.J.3
  • 15
    • 70449480937 scopus 로고    scopus 로고
    • Renal adverse effects of nonsteroidal antiinflammatory drugs
    • Harirforoosh S, Jamali F. Renal adverse effects of nonsteroidal antiinflammatory drugs. Expert Opin Drug Saf. 2009;8(6):669–681.
    • (2009) Expert Opin Drug Saf , vol.8 , Issue.6 , pp. 669-681
    • Harirforoosh, S.1    Jamali, F.2
  • 16
    • 47249107258 scopus 로고    scopus 로고
    • Topical agents in the treatment of rheumatic pain
    • Moore RA, Derry S, McQuay HJ. Topical agents in the treatment of rheumatic pain. Rheum Dis Clin North Am. 2008;34(2):415–432.
    • (2008) Rheum Dis Clin North Am , vol.34 , Issue.2 , pp. 415-432
    • Moore, R.A.1    Derry, S.2    McQuay, H.J.3
  • 17
    • 68249114476 scopus 로고    scopus 로고
    • Pharmacological management of persistent pain in older persons
    • American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatric Soc. 2009;57(8): 1331–1346.
    • (2009) J Am Geriatric Soc , vol.57 , Issue.8 , pp. 1331-1346
  • 18
    • 80052760192 scopus 로고    scopus 로고
    • PA: Endo Pharmaceuticals Inc
    • Voltaren Gel (diclofenac sodium topical gel) 1% Prescribing information. Chadds Ford, PA: Endo Pharmaceuticals Inc; 2009.
    • (2009) Chadds Ford
  • 19
    • 84908407858 scopus 로고    scopus 로고
    • Hazelwood, MO: Mallinckrodt Inc
    • Pennsaid (diclofenac sodium topical solution) 1.5% w/w Prescribing information. Hazelwood, MO: Mallinckrodt Inc; 2010.
    • (2010)
  • 20
    • 0031852889 scopus 로고    scopus 로고
    • In vitro cutaneous disposition of a topical diclofenac lotion in human skin: Effect of a multi-dose regimen
    • Hewitt PG, Poblete N, Wester RC, Maibach HI, Shainhouse JZ. In vitro cutaneous disposition of a topical diclofenac lotion in human skin: effect of a multi-dose regimen. Pharm Res. 1998;15(7):988–992.
    • (1998) Pharm Res , vol.15 , Issue.7 , pp. 988-992
    • Hewitt, P.G.1    Poblete, N.2    Wester, R.C.3    Maibach, H.I.4    Shainhouse, J.Z.5
  • 21
    • 0024797821 scopus 로고
    • The barrier function of the skin in relation to percutaneous absorption of drugs
    • Wiechers JW. The barrier function of the skin in relation to percutaneous absorption of drugs. Pharm Weekbl Sci. 1989;11(6):185–198.
    • (1989) Pharm Weekbl Sci , vol.11 , Issue.6 , pp. 185-198
    • Wiechers, J.W.1
  • 23
    • 4344581424 scopus 로고    scopus 로고
    • Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: A randomized controlled trial
    • Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ. 2004;171(4):333–338.
    • (2004) CMAJ , vol.171 , Issue.4 , pp. 333-338
    • Bookman, A.A.1    Williams, K.S.2    Shainhouse, J.Z.3
  • 24
    • 5044225002 scopus 로고    scopus 로고
    • Efficacy and safety of a topical diclofenac solution (Pennsaid) in the treatment of primary osteoarthritis of the knee: A randomized, double-blind, vehicle-controlled clinical trial
    • Roth SH, Shainhouse JZ. Efficacy and safety of a topical diclofenac solution (Pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial. Arch Intern Med. 2004;164(18):2017–2023.
    • (2004) Arch Intern Med , vol.164 , Issue.18 , pp. 2017-2023
    • Roth, S.H.1    Shainhouse, J.Z.2
  • 25
    • 24944584850 scopus 로고    scopus 로고
    • Treatment of osteoarthritis of the knee with a topical diclofenac solution: A randomised controlled, 6-week trial [ISRCTN53366886]
    • Baer PA, Thomas LM, Shainhouse Z. Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]. BMC Musculoskelet Disord. 2005;6:44.
    • (2005) BMC Musculoskelet Disord , vol.6 , pp. 44
    • Baer, P.A.1    Thomas, L.M.2    Shainhouse, Z.3
  • 27
    • 5044240146 scopus 로고    scopus 로고
    • ®) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial
    • ®) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. J Rheumatol. 2004;31(10):2002–2012.
    • (2004) J Rheumatol , vol.31 , Issue.10 , pp. 2002-2012
    • Tugwell, P.S.1    Wells, G.A.2    Shainhouse, J.Z.3
  • 29
    • 17744407929 scopus 로고    scopus 로고
    • Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III
    • Bellamy N, Kirwan J, Boers M, et al. Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III. J Rheumatol. 1997;24(4):799–802.
    • (1997) J Rheumatol , vol.24 , Issue.4 , pp. 799-802
    • Bellamy, N.1    Kirwan, J.2    Boers, M.3
  • 30
    • 0029857984 scopus 로고    scopus 로고
    • Design and conduct of clinical trials in patients with osteoarthritis: Recommendations from a task force of the Osteoarthritis Research Society. Results from a workshop
    • Altman R, Brandt K, Hochberg M, et al. Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a task force of the Osteoarthritis Research Society. Results from a workshop. Osteoarthritis Cartilage. 1996;4(4):217–243.
    • (1996) Osteoarthritis Cartilage , vol.4 , Issue.4 , pp. 217-243
    • Altman, R.1    Brandt, K.2    Hochberg, M.3
  • 31
    • 0029949760 scopus 로고    scopus 로고
    • Osteoarthritis section. Recommendations for the registration of drugs used in the treatment of osteoarthritis
    • Group for the Respect of Ethics and Excellence in Science (GREES): Osteoarthritis section. Recommendations for the registration of drugs used in the treatment of osteoarthritis. Ann Rheum Dis. 1996;55(8): 552–557.
    • (1996) Ann Rheum Dis , vol.55 , Issue.8 , pp. 552-557
  • 32
    • 0026566580 scopus 로고
    • Osteoarthritis antirheumatic drug trials. III. Setting the delta for clinical trials – results of a consensus development (Delphi) exercise
    • Bellamy N, Carette S, Ford PM, et al. Osteoarthritis antirheumatic drug trials. III. Setting the delta for clinical trials – results of a consensus development (Delphi) exercise. J Rheumatol. 1992;19(3):451–457.
    • (1992) J Rheumatol , vol.19 , Issue.3 , pp. 451-457
    • Bellamy, N.1    Carette, S.2    Ford, P.M.3
  • 33
    • 0031683546 scopus 로고    scopus 로고
    • In vivo bioavailability and metabolism of topical diclofenac lotion in human volunteers
    • Hui X, Hewitt PG, Poblete N, Maibach HI, Shainhouse JZ, Wester RC. In vivo bioavailability and metabolism of topical diclofenac lotion in human volunteers. Pharm Res. 1998;15(10):1589–1595.
    • (1998) Pharm Res , vol.15 , Issue.10 , pp. 1589-1595
    • Hui, X.1    Hewitt, P.G.2    Poblete, N.3    Maibach, H.I.4    Shainhouse, J.Z.5    Wester, R.C.6
  • 34
    • 72749102021 scopus 로고    scopus 로고
    • Systemic bioavailability of topical diclofenac sodium gel 1% versus oral diclofenac sodium in healthy volunteers
    • Kienzler JL, Gold M, Nollevaux F. Systemic bioavailability of topical diclofenac sodium gel 1% versus oral diclofenac sodium in healthy volunteers. J Clin Pharmacol. 2010;50(1):50–61.
    • (2010) J Clin Pharmacol , vol.50 , Issue.1 , pp. 50-61
    • Kienzler, J.L.1    Gold, M.2    Nollevaux, F.3
  • 35
    • 0033020525 scopus 로고    scopus 로고
    • Are randomized control trial outcomes influenced by the inclusion of a placebo group? A systematic review of nonsteroidal antiinflammatory drug trials for arthritis treatment
    • Rochon PA, Binns MA, Litner JA, et al. Are randomized control trial outcomes influenced by the inclusion of a placebo group? A systematic review of nonsteroidal antiinflammatory drug trials for arthritis treatment. J Clin Epidemiol. 1999;52(2):113–122.
    • (1999) J Clin Epidemiol , vol.52 , Issue.2 , pp. 113-122
    • Rochon, P.A.1    Binns, M.A.2    Litner, J.A.3
  • 36
    • 78649685713 scopus 로고    scopus 로고
    • A long-term, open-label study to confirm the safety of topical diclofenac solution containing dimethyl sulfoxide in the treatment of the osteoarthritic knee
    • Shainhouse JZ, Grierson LM, Naseer Z. A long-term, open-label study to confirm the safety of topical diclofenac solution containing dimethyl sulfoxide in the treatment of the osteoarthritic knee. Am J Ther. 2010; 17(6):566–576.
    • (2010) Am J Ther , vol.17 , Issue.6 , pp. 566-576
    • Shainhouse, J.Z.1    Grierson, L.M.2    Naseer, Z.3
  • 37
    • 0020972645 scopus 로고
    • Toxicologic update of dimethyl sulfoxide
    • Rubin LF. Toxicologic update of dimethyl sulfoxide. Ann N Y Acad Sci. 1983;411:6–10.
    • (1983) Ann N Y Acad Sci , vol.411 , pp. 6-10
    • Rubin, L.F.1
  • 38
    • 0016409460 scopus 로고
    • The human toxicology of dimethyl sulfoxide
    • Brobyn RD. The human toxicology of dimethyl sulfoxide. Ann N Y Acad Sci. 1975;243:497–506.
    • (1975) Ann N Y Acad Sci , vol.243 , pp. 497-506
    • Brobyn, R.D.1
  • 39
    • 0020972646 scopus 로고
    • Ocular toxicology of dimethyl sulfoxide and effects on retinitis pigmentosa
    • Garcia CA. Ocular toxicology of dimethyl sulfoxide and effects on retinitis pigmentosa. Ann N Y Acad Sci. 1983;411:48–51.
    • (1983) Ann N Y Acad Sci , vol.411 , pp. 48-51
    • Garcia, C.A.1
  • 40
  • 41
    • 0026355105 scopus 로고
    • The incidence and progression of lens opacities
    • Taylor HR, Muñoz B. The incidence and progression of lens opacities. Aust N Z J Ophthalmol. 1991;19(4):353–356.
    • (1991) Aust N Z J Ophthalmol , vol.19 , Issue.4 , pp. 353-356
    • Taylor, H.R.1    Muñoz, B.2
  • 42
    • 0027988011 scopus 로고
    • Incidence and progression of cortical, nuclear, and posterior subcapsular cataracts
    • Italian-American Cataract Study Group. Incidence and progression of cortical, nuclear, and posterior subcapsular cataracts. Am J Ophthalmol. 1994;118(5):623–631.
    • (1994) Am J Ophthalmol , vol.118 , Issue.5 , pp. 623-631
  • 43
    • 0031438559 scopus 로고    scopus 로고
    • Incidence and progression of cortical and posterior subcapsular opacities: The Longitudinal Study of Cataract. The LSC Group
    • Leske MC, Chylack LT Jr, He Q, et al. Incidence and progression of cortical and posterior subcapsular opacities: the Longitudinal Study of Cataract. The LSC Group. Ophthalmology. 1997;104(12): 1987–1993.
    • (1997) Ophthalmology , vol.104 , Issue.12 , pp. 1987-1993
    • Leske, M.C.1    Chylack, L.T.2    He, Q.3
  • 44
    • 0029993615 scopus 로고    scopus 로고
    • Incidence and progression of nuclear opacities in the Longitudinal Study of Cataract
    • Leske MC, Chylack LT Jr, Wu SY, et al. Incidence and progression of nuclear opacities in the Longitudinal Study of Cataract. Ophthalmology. 1996;103(5):705–712.
    • (1996) Ophthalmology , vol.103 , Issue.5 , pp. 705-712
    • Leske, M.C.1    Chylack Lt, W.2
  • 45
    • 0031939645 scopus 로고    scopus 로고
    • Incidence of age-related cataract: The Beaver Dam Eye Study
    • Klein BE, Klein R, Lee KE. Incidence of age-related cataract: the Beaver Dam Eye Study. Arch Ophthalmol. 1998;116(2):219–225.
    • (1998) Arch Ophthalmol , vol.116 , Issue.2 , pp. 219-225
    • Klein, B.E.1    Klein, R.2    Lee, K.E.3
  • 46
    • 84908407857 scopus 로고    scopus 로고
    • Available from, Accessed August 11
    • US Food and Drug Administration. Public Health Advisory – FDA announces important changes and additional warnings for COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs). Available from: http://www.fda.gov/Drugs/DrugSafety/Postmarket DrugSafetyInformationforPatientsandProviders/ucm150314.htm. Accessed August 11, 2010.
    • (2010)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.