Generation and characterization of neutralizing human recombinant antibodies against antigenic site II of rabies virus glycoprotein

Applied Microbiology and Biotechnology

Volumn 96, Issue 2, 2012, Pages 357-366

  Sun, Lina ^a   Chen, Zhe ^a   Yu, Li ^a   Wei, Jingshuang ^b   Li, Chuan ^a   Jin, Jing ^a   Shen, Xinxin ^a   Lv, Xinjun ^a   Tang, Qing ^a   Li, Dexin ^a   Liang, Mifang ^a  

^a National Institute for Viral Disease Control and Prevention   (China)

^b North China Pharmaceutical Corporation   (China)

Author keywords

Glycoprotein (gp); Human Fab library; Monoclonal antibody (mAb); Postexposure prophylaxis (PEP); Rabies virus (RV)

Indexed keywords

ANTIBODY GENES; BINDING AFFINITIES; COMPETITION ANALYSIS; EPITOPE MAPPING; GLYCOPROTEIN (GP); HUMAN IGG; IMMUNE RESPONSE; IN-VITRO; IN-VIVO; MONOCLONAL ANTIBODIES (MAB); MONOCLONAL ANTIBODIES (MABS); POST-EXPOSURE; PROTECTIVE FUNCTION; RABIES VIRUS (RV); RECOMBINANT ANTIBODY;

ANTIGENS; BINDING ENERGY; GENES; MONOCLONAL ANTIBODIES; VIRUSES;

GLYCOPROTEINS;

IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; RABIES IMMUNOGLOBULIN; RABIES VACCINE; VIRUS GLYCOPROTEIN;

ANTIBODY; FLUORESCENCE; IMMUNE RESPONSE; INFECTIVITY; INHIBITION; NEUTRALIZATION; PROTEIN; RABIES; RECOMBINATION; VACCINATION; VIRUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HAMSTER; IMMUNE RESPONSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POST EXPOSURE PROPHYLAXIS; RABIES; RABIES VIRUS; VACCINATION; VIRION;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CRICETINAE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MESOCRICETUS; POST-EXPOSURE PROPHYLAXIS; RABIES; RABIES VIRUS; VIRAL PROTEINS;

RABIES VIRUS;

EID: 84866494502     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4171-4     Document Type: Article

References (34)

1. Bakker AB,MarissenWE, Kramer RA, Rice AB,WeldonWC,Niezgoda M, Hanlon CA, Thijsse S, Backus HH, de Kruif J, Dietzschold B, Rupprecht CE, Goudsmit J (2005) Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants. J Virol 79(14):9062-9068 (Pubitemid 40934817)
2. Bakker AB, Python C, Kissling CJ, Pandya P, Marissen WE, Brink MF, Lagerwerf F, Worst S, van Corven E, Kostense S, Hartmann K, Weverling GJ, Uytdehaag F, Herzog C, Briggs DJ, Rupprecht CE, Grimaldi R, Goudsmit J (2008) First administration to humans of a monoclonal antibody cocktail against rabies virus: Safety, tolerability, and neutralizing activity. Vaccine 26 (47):5922-5927
3. Barbas CF 3rd, Burton DR (1996) Selection and evolution of highaffinity human anti-viral antibodies. Trends Biotechol 14(7):230-234 (Pubitemid 26251772)
4. Barbas CF 3rd, Kang A, Lerner RA, Benkovic SJ (1991) Assembly of combinatorial antibody libraries on phage surfaces: The gene III site. Proc Natl Acad Sci USA 88(7):7978-7982 (Pubitemid 21915278)
5. Beatty JD, Beatty BG, Vlahos WG (1987) Measurement of monoclonal antibody affinity by non-competitive enzyme immunoassay. J Immunol Methods 100(1-2):173-179 (Pubitemid 17085455)
6. Benmansour A, Leblois H, Coulon P, Tuffereau C, Gaudin Y, Flamand A, Lafay F (1991) Antigenicity of rabies virus glycoprotein. J Virol 65(8):4198-4203
7. Champion JM, Kean RB, Rupprecht CE, Notkins AL, Koprowski H, Dietzschold B, Hooper DC (2000) The development of monoclonal human rabies virus-neutralizing antibodies as a substitute for pooled human immune globulin in the prophylactic treatment of rabies virus exposure. J Immunol Methods 235(1-2):81-90 (Pubitemid 30089786)
8. Dietzschold B, Gore M, Casali P, Ueki Y, Rupprecht CE, Notkins AL, Koprowski H (1990) Biological characterization of human monoclonal antibodies to rabies virus. J Virol 64(6):3087-3090 (Pubitemid 20171306)
9. Enssle K, Kurrle R, Kohler R, Muller H, Kanzy EJ, Hilfenhaus J, Seiler FR (1991) A rabies-specific human monoclonal antibody that protects mice against lethal rabies. Hybridoma 10(5):547-556
10. Goudsmit J, Marissen WE, Weldon WC, Niezgoda M, Hanlon CA, Rice AB, Kruif J, Dietzschold B, Bakker AB, Rupprecht CE (2006) Comparison of an anti-rabies human monoclonal antibody combination with human polyclonal anti-rabies immune globulin. J Infect Dis 193(6):796-801
11. Hanlon CA, DeMattos CA, DeMattos CC, Niezgoda M, Hooper DC, Koprowski H, Notkins A, Rupprecht CE (2001a) Experimental utility of rabies virus-neutralizing human monoclonal antibodies in post-exposure prophylaxis. Vaccine 19(28-29):3834-3842 (Pubitemid 32566304)
12. Hanlon CA, Niezgoda M, Morrill PA, Rupprecht CE (2001b) The incurable wound revisited: Progress in human rabies prevention? Vaccine 19(17-19):2273-2279 (Pubitemid 32234227)
13. Houimel M, Dellagi K (2009) Isolation and characterization of human neutralizing antibodies to rabies virus derived from a recombinant immune antibody library. J Virol Methods 161(2):205-215
14. John de Kruif ABHB, MarissenWE, Kramer RA, ThrosbyM, Rupprecht CE, Goudsmit J (2007) A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis. Annu Rev Med 58:359-368 (Pubitemid 46706520)
15. Kashyap AK, Steel J, Oner AF, DillonMA, Swale RE,WallKM, Perry KJ, Faynboym A, Ilhan M, HorowitzM, Horowitz L, Palese P, Bhatt RR, Lerner RA (2008) Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies. Proc Natl Acad Sci U S A 105(16):5986-5991 (Pubitemid 351758386)
16. Kramer RA, Marissen WE, Goudsmit J, Visser TJ, Clijsters-Van der Horst M, Bakker AQ, de Jong M, Jongeneelen M, Thijsse S, Backus HH, Rice AB, Weldon WC, Rupprecht CE, Dietzschold B, Bakker AB, de Kruif J (2005) The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries. Eur J Immunol 35(7):2131-2145 (Pubitemid 41015052)
17. Lafon M, Wiktor TJ, Macfarlan RI (1983) Antigenic sites on the CVS rabies virus glycoprotein: Analysis with monoclonal antibodies. J Gen Virol 64(Pt 4):843-851 (Pubitemid 13163222)
18. Lafon M, Ideler J, Wunner WH (1984) Investigation of the antigenic structure of rabies virus glycoprotein by monoclonal antibodies. Dev Biol Stand 57:219-225
19. Liang M, Dubel S, Li D, Queitsch I, Li W, Bautz EK (2001) Baculovirus expression cassette vectors for rapid production of complete human IgG from phage display selected antibody fragments. J Immunol Methods 247(1-2):119-130 (Pubitemid 32057050)
20. MarissenWE, Kramer RA, Rice A,WeldonWC, Niezgoda M, Faber M, Slootstra JW, Meloen RH, Clijsters-van der Horst M, Visser TJ, Jongeneelen M, Thijsse S, Throsby M, de Kruif J, Rupprecht CE, Dietzschold B, Goudsmit J, Bakker AB (2005) Novel rabies virusneutralizing epitope recognized by human monoclonal antibody: Fine mapping and escape mutant analysis. J Virol 79(8):4672-4678 (Pubitemid 40464218)
21. Matsumoto T, Yamada K, Noguchi K, Nakajima K, Takada K, Khawplod P, Nishizono A(2010) Isolation and characterization of novel human monoclonal antibodies possessing neutralizing ability against rabies virus. Microbiol Immunol 54(11):673-683
22. Muller T, Batza HJ, Beckert A, Bunzenthal C, Cox JH, Freuling CM, Fooks AR, Frost J, Geue L, Hoeflechner A, Marston D, Neubert A, Neubert L, Revilla-Fernandez S,Vanek E,Vos A,Wodak E, Zimmer K, Mettenleiter TC (2009) Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria. Arch Virol 154(7):1081-1091
23. Prehaud C, Coulon P, LaFay F, Thiers C, Flamand A (1988) Antigenic site II of the rabies virus glycoprotein: Structure and role in viral virulence. J Virol 62(1):1-7 (Pubitemid 18050784)
24. Prehaud C, Takehara K, Flamand A, Bishop DH (1989) Immunogenic and protective properties of rabies virus glycoprotein expressed by baculovirus vectors. Virology 173(2):390-399 (Pubitemid 20014466)
25. Prosniak M, Faber M, Hanlon CA, Rupprecht CE, Hooper DC, Dietzschold B (2003) Development of a cocktail of recombinantexpressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies. J Infect Dis 188(1):53-56 (Pubitemid 36829741)
26. Redwan el RM, Fahmy A, El Hanafy A, Abd El-Baky N, Sallam SM (2009) Ovine anti-rabies antibody production and evaluation. Comp Immunol Microbiol Infect Dis 32(1):9-19
27. Rupprecht CE, Gibbons RV (2004) Clinical practice. Prophylaxis against rabies. N Engl J Med 351(25):2626-2635 (Pubitemid 39628584)
28. Rupprecht CE, Hanlon CA, Hemachudha T (2002) Rabies reexamined. Lancet Infect Dis 2(6):327-343
29. Shiota S, Mannen K, Matsumoto T, Yamada K, Yasui T, Takayama K, Kobayashi Y, Khawplod P, Gotoh K, Ahmed K, Iha H, Nishizono A (2009) Development and evaluation of a rapid neutralizing antibody test for rabies. J Virol Methods 161:58-62
30. Sloan SE, Hanlon C, Weldon W, Niezgoda M, Blanton J, Self J, Rowley KJ, Mandell RB, Babcock GJ, Thomas WD Jr, Rupprecht CE, Ambrosino DM (2007) Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates. Vaccine 25(15):2800-2810 (Pubitemid 46412574)
31. Stephenson I, Wood JM, Nicholson KG, Zambon MC (2003) Sialic acid receptor specificity on erythrocytes affects detection of antibody to avian influenza haemagglutinin. J Med Virol 70(3):391-398 (Pubitemid 36638052)
32. Sun L, Lu X, Li C,Wang M, Liu Q, Li Z, Hu X, Li J, Liu F, Li Q, Belser JA, Hancock K, Shu Y, Katz JM, LiangM, Li D (2009) Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses. PLoS One 4(5):e5476
33. Suwansrinon K, Jaijaroensup W, Daviratanasilpa S, Sriaroon C, Wilde H, Sitprija V (2005) Adverse reactions to human rabies immune globulin manufactured by the Thai Red Cross Society. Vaccine 23 (11):1324-1325 (Pubitemid 40127323)
34. Suwansrinon K, JaijareonsupW,Wilde H, Benjavongkulchai M, Sriaroon C, Sitprija V (2007) Sex-and age-related differences in rabies immunoglobulin hypersensitivity. Trans R Soc Trop Med Hyg 101(2):206-208 (Pubitemid 44835340)