The mobilization, recruitment and contribution of bone marrow-derived endothelial progenitor cells to the tumor neovascularization occur at an early stage and throughout the entire process of hepatocellular carcinoma growth

Oncology Reports

Volumn 28, Issue 4, 2012, Pages 1217-1224

  Zhu, Haitao ^a,b   Shao, Qianwen ^b   Sun, Xitai ^a   Deng, Zhengming ^a   Yuan, Xianwen ^a   Yu, Decai ^a   Zhou, Xiang ^a   Ding, Yitao ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Endothelial progenitor cells; Hepatocellular neoplasms; Neovascularization

Indexed keywords

CD133 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; PLATELET DERIVED GROWTH FACTOR; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED ENDOTHELIAL PROGENITOR CELL; CANCER GROWTH; CELL DIFFERENTIATION; CELL FUNCTION; CELL MOTILITY; CELL PROLIFERATION; CELL RECRUITMENT; CELLULAR DISTRIBUTION; CELLULAR PARAMETERS; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION; UPREGULATION; VASCULAR ENDOTHELIUM; VASCULAR ENDOTHELIUM CELL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD34; BLOOD CIRCULATION; BONE MARROW; CAPILLARIES; CARCINOMA, HEPATOCELLULAR; ENDOTHELIAL CELLS; GLYCOPROTEINS; GREEN FLUORESCENT PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDES; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866463459     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1944     Document Type: Article

References (43)

1. Asahara T, Murohara T, Sullivan A, et al: Isolation of putative progenitor endothelial cells for angiogenesis. Science 275: 964-967, 1997. (Pubitemid 27087709)
2. Asahara T, Masuda H, Takahashi T, et al: Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85: 221-218, 1999.
3. Mund JA and Case J: The role of circulating endothelial progenitor cells in tumor angiogenesis. Curr Stem Cell Res Ther 6: 115-121, 2011.
4. George AL, Bangalore-Prakash P, Rajoria S, et al: Endothelial progenitor cell biology in disease and tissue regeneration. J Hematol Oncol 24: 24, 2011.
5. Yoder MC: Defining human endothelial progenitor cells. J Thromb Haemost 7: 49-52, 2009.
6. Doyle B, Metharom P and Caplice NM: Endothelial progenitor cells. Endothelium 13: 403-410, 2006. (Pubitemid 44941971)
7. Chao H and Hirschi KK: Hemato-vascular origins of endothelial progenitor cells? Microvasc Res 79: 169-173, 2010.
8. Zhu AX, Duda DG, Sahani DV, et al: HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol 8: 292-301, 2011.
9. Kim HC, Chung JW, Lee W, et al: Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avoid complications of transcatheter arterial chemoembolization. Radiographics 25: S25-S39, 2005. (Pubitemid 41686060)
10. Lyden D, Hattori K, Dias S, et al: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7: 1194-1201, 2005. (Pubitemid 33063774)
11. Mellick AS, Plummer PN, Nolan DJ, et al: Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth. Cancer Res 70: 7273-7282, 2010.
12. Rigolin GM, Maffei R, Rizzotto L, et al: Circulating endothelial cells in patients with chronic lymphocytic leukemia: clinical-prognostic and biologic significance. Cancer 116: 1926-1937, 2010.
13. Hagensen MK, Raarup MK, Mortensen MB, et al: Circulating endothelial progenitor cells do not contribute to regeneration of endothelium after murine arterial injury. Cardiovasc Res 93: 223-231, 2012.
14. Wickersheim A, Kerber M, de Miguel LS, et al: Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors. Int J Cancer 125: 1771-1777, 2009.
15. Sieghart W, Fellner S, Reiberger T, et al: Differential role of circulating endothelial progenitor cells in cirrhotic patients with or without hepatocellular carcinoma. Dig Liver Dis 41: 902-906, 2009.
16. Ho JW, Pang RW, Lau C, et al: Significance of circulating endothelial progenitor cells in hepatocellular carcinoma. Hepatology 44: 836-843, 2006. (Pubitemid 46489546)
17. Yu D, Sun X, Qiu Y, et al: Identification and clinical significance of mobilized endothelial progenitor cells in tumor vasculogenesis of hepatocellular carcinoma. Clin Cancer Res 13: 3814-3824, 2007. (Pubitemid 47037586)
18. Sangidorj O, Yang SH, Jang HR, et al: Bone marrow-derived endothelial progenitor cells confer renal protection in a murine chronic renal failure model. Am J Physiol Renal Physiol 299: F325-F335, 2010.
19. Hu J, Dong A, Fernandez-Ruiz V, et al: Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res 69: 6951-6959, 2009.
20. + cells identifies a population of functional endothelial precursors. Blood 95: 952-958, 2000.
21. +, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia. J Clin Oncol 23: 5688-5695, 2005.
22. Suriano R, Chaudhuri D, Johnson RS, et al: 17Beta-estradiol mobilizes bone marrow-derived endothelial progenitor cells to tumors. Cancer Res 68: 6038-6042, 2008.
23. Schmitz V, Tirado-Ledo L, Tiemann K, et al: Establishment of an orthotopic tumor model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in mice. J Hepatol 40: 787-791, 2004. (Pubitemid 38507359)
24. Ahn JB, Rha SY, Shin SJ, et al: Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients. Cancer Lett 288: 124-132, 2010.
25. + liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology 49: 1277-1286, 2009.
26. + population in hepatocellular carcinoma. Int J Cancer 126: 2067-2078, 2010.
27. Arbab AS, Pandit SD, Anderson SA, et al: Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis. Stem Cells 24: 671-687, 2006.
28. Shirakawa K, Furuhata S, Watanabe I, et al: Induction of vasculogenesis in breast cancer models. Br J Cancer 87: 1454-1461, 2002. (Pubitemid 36044323)
29. Croll SD, Ransohoff RM, Cai N, et al: VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol 187: 388-402, 2004. (Pubitemid 38610285)
30. Gehling, U.M, Ergun S, Schumacher U, et al: In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood 95: 3106-3112, 2000. (Pubitemid 30321161)
31. Messerini L, Novelli L and Comin CE: Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma. J Clin Pathol 57: 867-871, 2004. (Pubitemid 39061438)
32. Pinzani M and Vizzutti F: Fibrosis and cirrhosis reversibility: clinical features and implications. Clin Liver Dis 12: 901-913, 2008.
33. Moon MH, Kim SY, Kim YJ, et al: Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia. Cell Physiol Biochem 17: 279-290, 2006.
34. Thomas J. O'Neill IV, Brian R, et al: Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells. Circ Res 97: 1027-1035, 2005.
35. Hämmerling GJ and Ganss R: Vascular integration of endothelial progenitors during multistep tumor progression. Cell Cycle 5: 509-511, 2006. (Pubitemid 43348366)
36. Nolan D J, Ciarrocchi A, Mellick AS, et al: Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev 12: 1546-1558, 2007. (Pubitemid 46955726)
37. He Y, Rajantie I, Ilmonen M, et al: Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res 64: 3737-3740, 2004. (Pubitemid 38697279)
38. Ryschich E, Schmidt J, Hammerling GJ, et al: Transformation of the microvascular system during multistage tumorigenesis. Int J Cancer 97: 719-725, 2002. (Pubitemid 34106323)
39. Dar A, Domev H, Ben-Yosef O, et al: Multipotent vasculogenic pericytes from human pluripotent stem cells promote recovery of murine ischemic limb. Circulation 125: 87-99, 2012.
40. Poon RT, Lau C, Yu WC, et al: High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolization in hepatocellular carcinoma: a prospective study. Oncol Rep 11: 1077-1084, 2004.
41. Wang B, Xu H, Gao ZQ, et al: Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization. Acta Radiol 49: 523-529, 2008.
42. Shaked Y, Henke E, Roodhart JM, et al: Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell 14: 263-273, 2008.
43. Pircher A, Kähler CM, Skvortsov S, et al: Increased numbers of endothelial progenitor cells in peripheral blood and tumor specimens in non-small cell lung cancer: a methodological challenge and an ongoing debate on the clinical relevance. Oncol Rep 19: 345-352, 2008. (Pubitemid 351176093)