Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma and adenocarcinoma

Molecular Medicine Reports

Volumn 6, Issue 5, 2012, Pages 973-976

  Xiang, Li ^a   Wang, Shiqi ^a   Jin, Xianqing ^a   Duan, Wenjuan ^a   Ding, Xionghui ^a   Zheng, Chang ^b  

^a CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Colorectal adenocarcinoma; Colorectal adenoma; Colorectal hamartomatous polyposis; Colorectal juvenile polyp; Toll like receptor 4

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CYCLOOXYGENASE 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ARTICLE; CHILD; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; COLORECTAL POLYP; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GROUPS BY AGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JUVENILE; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PRESCHOOL CHILD; PROTEIN EXPRESSION; SCHOOL CHILD;

ADENOCARCINOMA; ADENOMA; ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEIN 2; CHILD; CHILD, PRESCHOOL; COLONIC POLYPS; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MIDDLE AGED; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 84866459146     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1046     Document Type: Article

References (13)

1. Half E, Gldberg Y, Kariv R, et al: Guidelines for diagnosis, treatment, surveillance and prevention of cancer in patients with familiar non-adenomatous polyposis. Harefuah 150: 60, 2011.
2. Morson BG: Genesis of colorectal cancer. Clin Gastroenterol 5: 505-507, 1976.
3. Winawer SJ, Zauber AG, Fletcher RH, et al: Guidelines for colonoscopy surveillance after polypectomy. A consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Gastroenterol 130: 1872-1885, 2006. (Pubitemid 43668826)
4. Takeda K, Kaisho T and Akira S: Toll-like receptors. Annu Rev Immunol 21: 335-367, 2003.
5. He X and Bai H: Current progress on the investigation of Toll-like receptor. Northwest National Defense Medical Journal 31: 445-446, 2010 (In Chinese).
6. Salaun B, Coste I, Rissoan MC, et al: TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 176: 4894-4901, 2006.
7. Jin H and Meng Q: Measurement of TLR4 expression in human colon cancer by semi quantitative RT-PCR. Journal of Modern Applied Medicine 21: 682-684, 2009 (In Chinese).
8. Bendelac A and Medzhitov R: Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med 195: F19-F23, 2002. (Pubitemid 34461498)
9. He L, Zhang L, Li Z and Zhang Q: The roles of toll-like receptors in carcinogenesis and cancer immunotherapy. Chin Ger Journal Clin Oncol 9: 118-120, 2010.
10. Fiocchi C: TGF -beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation. J Clin Invest 108: 523-526, 2001.
11. Hardwick JC, Van Den Brink GR, Bleuming SA, et al: Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology 126: 111-121, 2004. (Pubitemid 38040729)
12. Zhang F, Warskulat U, Wettstein M, et al: Hyperosmolarity stimulates prostaglandin synthesis and cyclooxygenase-2 expression in activated rat liver macrophages. Biochem J 312: 135-143, 1995.
13. Wasilewicz MP, Kołodziej B, Bojułko T, et al: Expression of cyclooxygenase-2 in colonic polyps. Pol Arch Med Wewn 120: 313-320, 2010.