High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: The Toranomon Hospital Health Management Center Study 8 (TOPICS 8)

Diabetic Medicine

Volumn 29, Issue 10, 2012, Pages 1285-1290

  Heianza, Y ^a,b   Arase, Y ^b,c   Fujihara, K ^a   Tsuji, H ^b,c   Saito, K ^a,b   Hsieh, S D ^b,c   Kodama, S ^a,b   Shimano, H ^a   Yamada, N ^a   Hara, S ^b,c   Sone, H ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TORANOMON HOSPITAL   (Japan)

^c Okinaka Memorial Institute for Medical Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; HEMOGLOBIN A1C; INSULIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ASSESSMENT TOOL; CONCENTRATION (PARAMETERS); DIABETES MELLITUS; FEMALE; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; JAPAN; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; OUTPATIENT; PANCREAS ISLET BETA CELL;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CROSS-SECTIONAL STUDIES; FASTING; FEMALE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; JAPAN; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84866437534     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03667.x     Document Type: Article

References (27)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33(Suppl 1): S62-S69.
2. Bonora E, Tuomilehto J. The pros and cons of diagnosing diabetes with A1C. Diabetes Care 2011; 34(Suppl 2): S184-S190.
3. Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care 2011; 34: e61-e99.
4. Kanat M, Winnier D, Norton L, Arar N, Jenkinson C, Defronzo RA et al. The relationship between β-cell function and glycated hemoglobin: results from the veterans administration genetic epidemiology study. Diabetes Care 2011; 34: 1006-1010.
5. Lorenzo C, Wagenknecht LE, Hanley AJ, Rewers MJ, Karter AJ, Haffner SM. A1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Care 2010; 33: 2104-2109.
6. Saito I, Kokubo Y, Yamagishi K, Iso H, Inoue M, Tsugane S. Diabetes and the risk of coronary heart disease in the general Japanese population: the Japan Public Health Center-based prospective (JPHC) study. Atherosclerosis 2011; 216: 187-191.
7. Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Iwase M et al. Two risk score models for predicting incident Type 2 diabetes in Japan. Diabet Med 2012; 29: 107-114.
8. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462-1470.
9. Abdul-Ghani MA, Williams K, DeFronzo RA, Stern M. What is the best predictor of future type 2 diabetes? Diabetes Care 2007; 30: 1544-1548.
10. Utzschneider KM, Prigeon RL, Faulenbach MV, Tong J, Carr DB, Boyko EJ et al. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 2009; 32: 335-341.
11. The Committee of Japan Diabetes Society on the diagnostic criteria of diabetes mellitus. Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. J Jpn Diabetes Soc 2010; 53: 450-467.
12. Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA. β-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 2005; 90: 493-500.
13. Godsland IF, Jeffs JA, Johnston DG. Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 2004; 47: 1157-1166.
14. DeFronzo RA, Abdul-Ghani M. Type 2 diabetes can be prevented with early pharmacological intervention. Diabetes Care 2011; 34(Suppl 2): S202-S209.
15. Rhee SY, Kim JY, Chon S, Hwang YC, Jeong IK, Oh S et al. The changes in early phase insulin secretion in newly diagnosed, drug naive korean prediabetes subjects. Korean Diabetes J 2010; 34: 157-165.
16. Defronzo RA, Abdul-Ghani MA. Preservation of β-cell function: the key to diabetes prevention. J Clin Endocrinol Metab 2011; 96: 2354-2366.
17. Wang C, Tan H, Yu H, Zhang X, Suo L, Lu Z et al. Impairment of insulin action in non-obese, normal-glucose tolerant, first-degree relatives of Chinese type 2 diabetic patients. Diabetes Res Clin Pract 2011; 91: 67-71.
18. Fukushima M, Usami M, Ikeda M, Nakai Y, Taniguchi A, Matsuura T et al. Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes. Metabolism 2004; 53: 831-835.
19. Chen KW, Boyko EJ, Bergstrom RW, Leonetti DL, Newell-Morris L, Wahl PW et al. Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care 1995; 18: 747-753.
20. Matsumoto K, Miyake S, Yano M, Ueki Y, Yamaguchi Y, Akazawa S et al. Glucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care 1997; 20: 1562-1568.
21. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH et al. Epidemic obesity and type 2 diabetes in Asia. Lancet 2006; 368: 1681-1688.
22. Ramachandran A, Ma RC, Snehalatha C. Diabetes in Asia. Lancet 2010; 375: 408-418.
23. Lee JW, Brancati FL, Yeh HC. Trends in the prevalence of type 2 diabetes in Asians versus whites: results from the United States National Health Interview Survey, 1997-2008. Diabetes Care 2011; 34: 353-357.
24. Suzuki H, Fukushima M, Usami M, Ikeda M, Taniguchi A, Nakai Y et al. Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia. Diabetes Care 2003; 26: 1211-1215.
25. Sato Y, Komatsu M, Katakura M, Ohfusa H, Yamada S, Yamauchi K et al. Diminution of early insulin response to glucose in subjects with normal but minimally elevated fasting plasma glucose. Evidence for early beta-cell dysfunction. Diabet Med 2002; 19: 566-571.
26. Hayashi T, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY. Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans. Diabetes 2008; 57: 1269-1275.
27. Hoyer D, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY. Subcutaneous thigh fat area is unrelated to risk of type 2 diabetes in a prospective study of Japanese Americans. Diabetologia 2011; 54: 2795-2800.