A Mouse Model of Early-Onset Renal Failure Due to a Xanthine Dehydrogenase Nonsense Mutation

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Piret, Sian E ^a   Esapa, Christopher T ^a,b   Gorvin, Caroline M ^a   Head, Rosie ^a,b   Loh, Nellie Y ^a   Devuyst, Olivier ^c   Thomas, Gethin ^d   Brown, Steve D M ^b   Brown, Matthew ^a,d   Croucher, Peter ^e   Cox, Roger ^b   Thakker, Rajesh V ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Mammalian Genetics Unit   (United Kingdom)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; CREATININE; CYCLOOXYGENASE 2; N ETHYL N NITROUREA; UNCLASSIFIED DRUG; UREA; URIC ACID; XANTHINE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CELL INFILTRATION; CHROMOSOME 17; CHRONIC KIDNEY DISEASE; CODON; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; FIBROSING ALVEOLITIS; GENE; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENE SEGREGATION; GENOTYPING TECHNIQUE; GLOMERULUS; HISTOLOGY; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY STRUCTURE; LIMIT OF DETECTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; ONSET AGE; SINGLE NUCLEOTIDE POLYMORPHISM; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; XANTHINURIA; XDH GENE;

ANIMALS; BLOOD CHEMICAL ANALYSIS; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; CODON, NONSENSE; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; PHENOTYPE; RENAL INSUFFICIENCY; XANTHINE DEHYDROGENASE;

ANIMALIA; MUS;

EID: 84866428976     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045217     Document Type: Article

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