A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 32124-32135

  Marutani, Eizo ^a   Kosugi, Shizuko ^a   Tokuda, Kentaro ^a   Khatri, Ashok ^a   Nguyen, Rebecca ^a   Atochin, Dmitriy N ^a   Kida, Kotaro ^a   Van Leyen, Klaus ^a   Arai, Ken ^a   Ichinose, Fumito ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDES; BENZOIC ACID; BRAIN INJURY; CEREBRAL INFARCT; CEREBRAL ISCHEMIA AND REPERFUSION; CORTICAL NEURONS; GLUCOSE DEPRIVATION; GLUTATHIONES; HIGH CONCENTRATION; HUMAN NEUROBLASTOMA; IN-VITRO; INTRACELLULAR CALCIUM; MEMANTINE; N METHYL D ASPARTATE RECEPTOR; NEURONAL DEATH; NEUROPROTECTIVE EFFECTS; NEUROTOXICITY; PHYSIOLOGICAL LEVELS; REOXYGENATION; SODIUM SULFIDES; THERAPEUTIC STRATEGY;

AMIDES; CARBOXYLIC ACIDS; GLUCOSE; HYDROGEN SULFIDE; PLANTS (BOTANY); SODIUM; SODIUM COMPOUNDS;

NEURONS;

4 (3 THIOXO 3H 1,2 DITHIOL 4 YL)BENZOIC ACID; ACS 48; CALCIUM; CASPASE 3; GLUCOSE; GLUTAMIC ACID; HYDROGEN SULFIDE; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE; N (3,5 DIMETHYLADAMANTAN 1 YL) 4 (3 THIOXO 3H 1,2 DITHIOL 4 YL)BENZAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OXYGEN; SODIUM SULFIDE; SULFIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN NERVE CELL; BRAIN PERFUSION; CALCIUM CELL LEVEL; CELL LEVEL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL NECROSIS; NERVE FUNCTION; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; REOXYGENATION; SURVIVAL RATE;

ANIMALS; BRAIN INJURIES; BRAIN ISCHEMIA; CELL DEATH; CELL LINE, TUMOR; CELLS, CULTURED; DRUG DESIGN; EXCITATORY AMINO ACID ANTAGONISTS; GLUCOSE; GLUTATHIONE; HUMANS; HYDROGEN SULFIDE; ISCHEMIA; MALE; MEMANTINE; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; NEURONS; OXYGEN; RECEPTORS, N-METHYL-D-ASPARTATE; REPERFUSION INJURY;

MURINAE; MUS;

EID: 84866427378     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.374124     Document Type: Article

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