A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma

Oral Oncology

Volumn 48, Issue 10, 2012, Pages 1038-1044

  Huang, Pei Yu ^a   Cao, Ka Jia ^a   Guo, Xiang ^a   Mo, Hao Yuan ^a   Guo, Ling ^a   Xiang, Yan Qun ^a   Deng, Man Quan ^a   Qiu, Fang ^a   Cao, Su Mei ^a   Guo, Ying ^a   Zhang, Li ^a   Li, Ning Wei ^a   Sun, Rui ^a   Chen, Qiu Yan ^a   Luo, Dong Hua ^a   Hua, Yi Jun ^a   Mai, Hai Qiang ^a   Hong, Ming Huang ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Concurrent chemoradiotherapy; Induction chemotherapy; Nasopharyngeal carcinoma; Radiotherapy

Indexed keywords

CARBOPLATIN; FLOXURIDINE;

ADULT; ADVANCED CANCER; ANEMIA; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CONTROLLED STUDY; FEMALE; HUMAN; INDUCTION CHEMOTHERAPY; INTERMETHOD COMPARISON; KIDNEY DISEASE; LEUKOPENIA; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; RADIATION DOSE; RADIATION SICKNESS; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTOPENIA; TREATMENT RESPONSE; VOMITING;

ADOLESCENT; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CHEMORADIOTHERAPY; FEMALE; FLOXURIDINE; FOLLOW-UP STUDIES; HUMANS; INDUCTION CHEMOTHERAPY; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84866420451     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2012.04.006     Document Type: Article

References (26)

1. S.A. Yeh, Y. Tang, C.C. Lui, Y.J. Huang, and E.Y. Huang Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone Int J Radiat Oncol Biol Phys 62 2005 672 679
2. A.W. Lee, W.M. Sze, J.S. Au, S.F. Leung, T.W. Leung, and D.T. Chua Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience Int J Radiat Oncol Biol Phys 61 2005 1107 1116
3. Q.T. Le, D. Tate, A. Koong, I.C. Gibbs, S.D. Chang, and J.R. Adler Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 56 2003 1046 1054
4. N. Lee, P. Xia, J.M. Quivey, K. Sultanem, I. Poon, and C. Akazawa Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience Int J Radiat Oncol Biol Phys 53 2002 12 22
5. M. Huncharek, and B. Kupelnick Combined chemoradiation versus radiation therapy alone in locally advanced nasopharyngeal carcinoma: results of a meta-analysis of 1528 patients from six randomized trials Am J Clin Oncol 25 2002 219 223
6. J. Ma, H.Q. Mai, M.H. Hong, H.Q. Min, Z.D. Mao, and N.J. Cui Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma J Clin Oncol 19 2001 1350 1357
7. A.T. Chan, P.M. Teo, R.K. Ngan, T.W. Leung, W.H. Lau, and B. Zee Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial J Clin Oncol 20 2002 2038 2044
8. M.H. Hong, H.Q. Mai, H.Q. Min, J. Ma, E.P. Zhang, and N.J. Cui A comparison of the Chinese 1992 and fifth-edition International Union against cancer staging systems for staging nasopharyngeal carcinoma Cancer 89 2000 242 247
9. N.-N. Cheng, and R.-Y. Sun Introduction of software of the new drug statistical treatment (NDST) Chin J Clin Pharmacol Ther 2 1997 137 149
10. L. Tai-Xiang, L. Wei, and Z. Chong A probe of design methods of block shielding facio cervical portals at isocentre for radiotherapy of nasopharyngeal carcinoma Ai Zheng 19 2000 930 933
11. A.B. Miller, B. Hoogstraten, M. Staquet, and A. Winkler Reporting results of cancer treatment Cancer 47 1981 207 214
12. A. Trotti, R. Byhardt, J. Stetz, C. Gwede, B. Corn, and K. Fu Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy Int J Radiat Oncol Biol Phys 47 2000 13 47
13. J.C. Lin, J.S. Jan, C.Y. Hsu, W.M. Liang, R.S. Jiang, and W.Y. Wang Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival J Clin Oncol 21 2003 631 637
14. A.T. Chan, S.F. Leung, R.K. Ngan, P.M. Teo, W.H. Lau, and W.H. Kwan Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma J Natl Cancer Inst 97 2005 536 539
15. J.A. Langendijk, C.R. Leemans, J. Buter, J. Berkhof, and B.J. Slotman The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature J Clin Oncol 22 2004 4604 4612
16. B. Baujat, H. Audry, J. Bourhis, A.T. Chan, H. Onat, and D.T. Chua Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients Int J Radiat Oncol Biol Phys 64 2006 47 56
17. W. Yeo, T.W. Leung, A.T. Chan, S.K. Chiu, P. Yu, and T.S. Mok A phase II study of combination paclitaxel and carboplatin in advanced nasopharyngeal carcinoma Eur J Cancer 34 1998 2027 2031
18. S.S. Leong, J. Wee, S. Rajan, C.K. Toh, W.T. Lim, and S.W. Hee Triplet combination of gemcitabine, paclitaxel, and carboplatin followed by maintenance 5-fluorouracil and folinic acid in patients with metastatic nasopharyngeal carcinoma Cancer 113 2008 1332 1337
19. T.K. Yau, A.W. Lee, D.H. Wong, E.S. Pang, W.T. Ng, and R.M. Yeung Treatment of Stage IV(A-B) nasopharyngeal carcinoma by induction-concurrent chemoradiotherapy and accelerated fractionation: impact of chemotherapy schemes Int J Radiat Oncol Biol Phys 66 2006 1004 1010
20. I. Chitapanarux, V. Lorvidhaya, P. Kamnerdsupaphon, Y. Sumitsawan, E. Tharavichitkul, and V. Sukthomya Chemoradiation comparing cisplatin versus carboplatin in locally advanced nasopharyngeal cancer: randomised, non-inferiority, open trial Eur J Cancer 43 2007 1399 1406
21. B.B. Ma, E.P. Hui, and A.T. Chan Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: current and future directions Cancer Sci 99 2008 1311 1318
22. S.Z. Lai, W.F. Li, L. Chen, W. Luo, Y.Y. Chen, and L.Z. Liu How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys 80 2011 661 668
23. G. Sanguineti, P. Bossi, A. Pou, and L. Licitra Timing of chemoradiotherapy and patient selection for locally advanced nasopharyngeal carcinoma Clin Oncol (R Coll Radiol) 15 2003 451 460
24. A.W. Lee, S.Y. Tung, D.T. Chua, R.K. Ngan, R. Chappell, and R. Tung Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma J Natl Cancer Inst 102 2010 1188 1198
25. A.W. Lee, S.Y. Tung, A.T. Chan, R. Chappell, Y.T. Fu, and T.X. Lu A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma Radiother Oncol 98 2011 15 22
26. E.P. Hui, B.B. Ma, S.F. Leung, A.D. King, F. Mo, and M.K. Kam Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma J Clin Oncol 27 2009 242 249