The time between paraquat ingestion and a negative dithionite urine test in an independent risk factor for death and organ failure in acute paraquat intoxication

Journal of Korean Medical Science

Volumn 27, Issue 9, 2012, Pages 993-998

  Seok, Sujin ^a   Kim, Young hee ^a   Gil, Hyo wook ^a   Song, Ho yeon ^a   Hong, Sae yong ^a  

^a Soonchunhyang University College of Medicine   (South Korea)

Author keywords

Dithionite test; Intoxication; Mortality; Multiple organ failure; Paraquat; Risk factors

Indexed keywords

DITHIONITE; HERBICIDE; PARAQUAT;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; BLOOD; FEMALE; HUMAN; LIVER DISEASE; MALE; MIDDLE AGED; MORTALITY; RESPIRATORY FAILURE; RISK FACTOR; TIME; URINE;

ACUTE KIDNEY INJURY; ADULT; AGED; DITHIONITE; FEMALE; HERBICIDES; HUMANS; LIVER DISEASES; MALE; MIDDLE AGED; PARAQUAT; RESPIRATORY INSUFFICIENCY; RISK FACTORS; TIME FACTORS;

EID: 84866419809     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2012.27.9.993     Document Type: Article

References (24)

1. Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol 2011; 72: 745-57.
2. Lin JL, Lin-Tan DT, Chen KH, Huang WH, Hsu CW, Hsu HH, Yen TH. Improved survival in severe paraquat poisoning with repeated pulse therapy of cyclophosphamide and steroids. Intensive Care Med 2011; 37: 1006-13.
3. Moon JM, Chun BJ. The efficacy of high doses of vitamin C in patients with paraquat poisoning. Hum Exp Toxicol 2011; 30: 844-50.
4. Kim JH, Gil HW, Yang JO, Lee EY, Hong SY. Effect of glutathione administration on serum levels of reactive oxygen metabolites in patients with paraquat intoxication: a pilot study. Korean J Intern Med 2010; 25: 282-7.
5. Gil HW, Kim SJ, Yang JO, Lee EY, Hong SY. Clinical outcome of hemoperfusion in poisoned patients. Blood Purif 2010; 30: 84-8.
6. Suzuki K, Takasu N, Arita S, Maenosono A, Ishimatsu S, Nishina M, Tanaka S, Kohama A. A new method for predicting the outcome and survival period in paraquat poisoning. Hum Toxicol 1989; 8: 33-8.
7. Ragoucy-Sengler C, Pileire B. A biological index to predict patient outcome in paraquat poisoning. Hum Exp Toxicol 1996; 15: 265-8.
8. Yamaguchi H, Sato S, Watanabe S, Naito H. Pre-embarkment prognostication for acute paraquat poisoning. Hum Exp Toxicol 1990; 9: 381-4.
9. Ikebuchi J, Proudfoot AT, Matsubara K, Hampson EC, Tomita M, Suzuki K, Fuke C, Ijiri I, Tsunerari T, Yuasa I. Toxicological index of paraquat: a new strategy for assessment of severity of paraquat poisoning in 128 patients. Forensic Sci Int 1993; 59: 85-7.
10. Proudfoot AT, Stewart MS, Levitt T, Widdop B. Significance of plasmaparaquat concentrations. Lancet 1979; 2: 330-2.
11. Gil HW, Kang MS, Yang JO, Lee EY, Hong SY. Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients. Clin Toxicol (Phila) 2008; 46: 515-8.
12. Lee KH, Gil HW, Kim YT, Yang JO, Lee EY, Hong SY. Marked recovery from paraquat-induced lung injury during long-term follow-up. Korean J Intern Med 2009; 24: 95-100.
13. Kim YT, Jou SS, Lee HS, Gil HW, Yang JO, Lee EY, Hong SY. The area of ground glass opacities of the lungs as a predictive factor in acute paraquat intoxication. J Korean Med Sci 2009; 24: 636-40.
14. Kim SJ, Gil HW, Yang JO, Lee EY, Hong SY. The clinical features of acute kidney injury in patients with acute paraquat intoxication. Nephrol Dial Transplant 2009; 24: 1226-32.
15. Gil HW, Yang JO, Lee EY, Hong SY. Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxication. Clin Toxicol (Phila) 2009; 47: 870-5.
16. Shivhare P, Gupta VK. Spectrophotometric method for the determination of paraquat in water, grain and plant materials. Analyst 1991; 116: 391-3.
17. de Almeida RM, Yonamine M. Enzymatic-spectrophotometric determination of paraquat in urine samples: a method based on its toxic mechanism. Toxicol Mech Methods 2010; 20: 424-7.
18. Braithwaite RA. Emergency analysis of paraquat in biological fluids. Hum Toxicol 1987; 6: 83-6.
19. Kawase S, Kanno S, Skai S. Determination of the herbicides paraquat and diquat in blood and urine by gas chromatography. J Chromatogr 1984; 283: 231-40.
20. Bowles MR, Eyles DW, Hampson EC, Pond SM. Quantitation of paraquat in biological samples by radioimmunoassay using a monoclonal antibody. Fundam Appl Toxicol 1992; 19: 375-9.
21. Nagao M, Takatori T, Terazawa K, Wu B, Wakasugi C, Masui M, Ikeda H. Development and application of immunoassay for paraquat: radioimmunoassay. J Forensic Sci 1989; 34: 547-52.
22. Mayhew SG. The redox potential of dithionite and SO-2 from equilibrium reactions with flavodoxins, methyl viologen and hydrogen plus hydrogenase. Eur J Biochem 1978; 85: 535-47.
23. Houzé P, Baud FJ, Mouy R, Bismuth C, Bourdon R, Scherrmann JM. Toxicokinetics of paraquat in humans. Hum Exp Toxicol 1990; 9: 5-12.
24. Kang MS, Gil HW, Yang JO, Lee EY, Hong SY. Comparison between kidney and hemoperfusion for paraquat elimination. J Korean Med Sci 2009; 24: S156-60.