Potential role of the detection of enterobacterial DNA in blood for the management of neonatal necrotizing enterocolitis

Journal of Medical Microbiology

Volumn 61, Issue PART 10, 2012, Pages 1465-1472

  Mancini, Nicasio ^a   Poloniato, Antonella ^b   Ghidoli, Nadia ^a   Carletti, Silvia ^a   Fomasi, Martina ^b   Barera, Graziano ^b   Rovelli, Rosanna ^b   Cichero, Paola ^a   Burioni, Roberto ^a   Clementi, Massimo ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BACTERIAL DNA; C REACTIVE PROTEIN; GANCICLOVIR; METRONIDAZOLE; NETILMICIN;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM DETECTION; BLOOD ANALYSIS; BLOOD CULTURE; CASE REPORT; ENTEROBACTERIACEAE; FEMALE; HIGH RISK PATIENT; HUMAN; INTESTINE PERFORATION; MALE; MOLECULAR DIAGNOSIS; NECROTIZING ENTEROCOLITIS; NEWBORN; NEWBORN DISEASE; PREMATURITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ANTI-BACTERIAL AGENTS; CYTOMEGALOVIRUS INFECTIONS; DNA, BACTERIAL; ENTEROBACTER; ENTEROBACTERIACEAE INFECTIONS; ENTEROCOLITIS, NECROTIZING; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INTESTINAL PERFORATION; MALE; MULTIPLE BIRTH OFFSPRING;

EID: 84866419402     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.043067-0     Document Type: Article

References (33)

1. Brook, I. (2008). Microbiology and management of neonatal necrotizing enterocolitis. Am J Perinatol 25, 111-118.
2. Cheu, H. W., Brown, D. R. & Rowe, M. I. (1989). Breath hydrogen excretion as a screening test for the early diagnosis of necrotizing enterocolitis. Am J Dis Child 143, 156-159.
3. Claud, E. C. & Walker, W. A. (2008). Bacterial colonization, probiotics, and necrotizing enterocolitis. J Clin Gastroenterol 42 (Suppl. 2), S46-S52.
4. Cotten, C. M., Taylor, S., Stoll, B., Goldberg, R. N., Hansen, N. I., Sánchez, P. J., Ambalavanan, N., Benjamin, D. K., Jr & NICHD Neonatal Research Network (2009). Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics 123, 58-66.
5. De Marco, D., Perotti, M., Ossi, C. M., Burioni, R., Clementi, M. & Mancini, N. (2007). Development and validation of a molecular method for the diagnosis of medically important fungal infections. New Microbiol 30, 308-312.
6. Epelman, M., Daneman, A., Navarro, O. M., Morag, I., Moore, A. M., Kim, J. H., Faingold, R., Taylor, G. & Gerstle, J. T. (2007). Necrotizing enterocolitis: review of state-of-the-art imaging findings with pathologic correlation. Radiographics 27, 285-305.
7. Fitzgibbons, S. C., Ching, Y., Yu, D., Carpenter, J., Kenny, M., Weldon, C., Lillehei, C., Valim, C., Horbar, J. D. & Jaksic, T. (2009). Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg 44, 1072-1076.
8. Gessler, P., Bischoff, G. A., Wiegand, D., Essers, B. & Bossart, W. (2004). Cytomegalovirus-associated necrotizing enterocolitis in a preterm twin after breastfeeding. J Perinatol 24, 124-126.
9. Grave, G. D., Nelson, S. A., Walker, W. A., Moss, R. L., Dvorak, B., Hamilton, F. A., Higgins, R. & Raju, T. N. (2007). New therapies and preventive approaches for necrotizing enterocolitis: report of a research planning workshop. Pediatr Res 62, 510-514.
10. Guner, Y. S., Chokshi, N., Petrosyan, M., Upperman, J. S., Ford, H. R. & Grikscheit, T. C. (2008). Necrotizing enterocolitis-bench to bedside: novel and emerging strategies. Semin Pediatr Surg 17, 255-265.
11. Henry, M. C. & Moss, R. L. (2009). Necrotizing enterocolitis. Annu Rev Med 60, 111-124.
12. Horbar, J. D., Badger, G. J., Carpenter, J. H., Fanaroff, A. A., Kilpatrick, S., LaCorte, M., Phibbs, R., Soll, R. F. & Members of the Vermont Oxford Network (2002). Trends in mortality and morbidity for very low birth weight infants, 1991-1999. Pediatrics 110, 143-151.
13. Hsueh, W., Caplan, M. S., Qu, X. W., Tan, X. D., De Plaen, I. G. & Gonzalez-Crussi, F. (2003). Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol 6, 6-23.
14. Krediet, T. G., van Lelyveld, N., Vijlbrief, D. C., Brouwers, H. A. A., Kramer, W. L. M., Fleer, A. & Gerards, L. J. (2003). Microbiological factors associated with neonatal necrotizing enterocolitis: protective effect of early antibiotic treatment. Acta Paediatr 92, 1180-1182.
15. Lehmann, L. E., Hunfeld, K. P., Emrich, T., Haberhausen, G., Wissing, H., Hoeft, A. & Stüber, F. (2008). A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol (Berl) 197, 313-324.
16. Lucignano, B., Ranno, S., Liesenfeld, O., Pizzorno, B., Putignani, L., Bernaschi, P. & Menichella, D. (2011). Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol 49, 2252-2258.
17. Mancini, N., Ossi, C. M., Perotti, M., Carletti, S., Gianni, C., Paganoni, G., Matusuka, S., Guglielminetti, M., Cavallero, A. & other authors (2005a). Direct sequencing of Scedosporium apiospermum DNA in the diagnosis of a case of keratitis. J Med Microbiol 54, 897-900.
18. Mancini, N., Ossi, C. M., Perotti, M., Clementi, M., DiGiulio, D. B., Schaenman, J. M., Montoya, J. G., McClenny, N. B., Berry, G. J. & other authors (2005b). Molecular mycological diagnosis and correct antimycotic treatments. J Clin Microbiol 43, 3584, author reply 3584-3585.
19. Mancini, N., Perotti, M., Ossi, C. M., Cavallero, A., Matuska, S., Paganoni, G., Burioni, R., Rama, P. & Clementi, M. (2006). Rapid molecular identification of fungal pathogens in corneal samples from suspected keratomycosis cases. J Med Microbiol 55, 1505-1509.
20. Mancini, N., Clerici, D., Diotti, R., Perotti, M., Ghidoli, N., De Marco, D., Pizzorno, B., Emrich, T., Burioni, R. & other authors (2008). Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies. J Med Microbiol 57, 601-604.
21. Mancini, N., Carletti, S., Ghidoli, N., Cichero, P., Ossi, C. M., Ieri, R., Poli, E., Burioni, R. & Clementi, M. (2009). Molecular diagnosis of polymicrobial sepsis. J Clin Microbiol 47, 1274-1275.
22. Mancini, N., Carletti, S., Ghidoli, N., Cichero, P., Burioni, R. & Clementi, M. (2010). The era of molecular and other non-culturebased methods in diagnosis of sepsis. Clin Microbiol Rev 23, 235-251.
23. Mussap, M., Molinari, M. P., Senno, E., Gritti, P., Soro, B., Mannelli, S. & Fabris, C. (2007). New diagnostic tools for neonatal sepsis: the role of a real-time polymerase chain reaction for the early detection and identification of bacterial and fungal species in blood samples. J Chemother 19 (Suppl. 2), 31-34.
24. Neu, J. & Walker, W. A. (2011). Necrotizing enterocolitis. N Engl J Med 364, 255-264.
25. Obladen, M. (2009). Necrotizing enterocolitis-150 years of fruitless search for the cause. Neonatology 96, 203-210.
26. Paolucci, M., Capretti, M. G., Dal Monte, P., Corvaglia, L., Landini, M. P., Varani, S., Pession, A., Faldella, G. & Sambri, V. (2009). Laboratory diagnosis of late-onset sepsis in newborns by multiplex real-time PCR. J Med Microbiol 58, 533-534.
27. Patel, S., Dammann, O., Martin, C. R., Allred, E. N., Leviton, A. & ELGAN Study Investigators (2011). Presumed and definite bacteremia in extremely low gestational age newborns. Acta Paediatr 100, 36-41.
28. Pierro, A. & Hall, N. (2003). Surgical treatments of infants with necrotizing enterocolitis. Semin Neonatol 8, 223-232.
29. Pryce, T. M., Palladino, S., Kay, I. D. & Coombs, G. W. (2003). Rapid identification of fungi by sequencing the ITS1 and ITS2 regions using an automated capillary electrophoresis system. Med Mycol 41, 369-381.
30. Sharma, R., Tepas, J. J., III, Hudak, M. L., Mollitt, D. L., Wludyka, P. S., Teng, R. J. & Premachandra, B. R. (2007). Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis. J Pediatr Surg 42, 454-461.
31. Smith, B., Bodé, S., Petersen, B. L., Jensen, T. K., Pipper, C., Kloppenborg, J., Boyé, M., Krogfelt, K. A. & Mølbak, L. (2011). Community analysis of bacteria colonizing intestinal tissue of neonates with necrotizing enterocolitis. BMC Microbiol 11, 73.
32. Thuijls, G., Derikx, J. P., van Wijck, K., Zimmermann, L. J., Degraeuwe, P. L., Mulder, T. L., Van der Zee, D. C., Brouwers, H. A., Verhoeven, B. H. & other authors (2010). Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. Ann Surg 251, 1174-1180.
33. Walsh, M. C. & Kliegman, R. M. (1986). Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 33, 179-201.