Efficient discovery of chromatography equipment sizing strategies for antibody purification processes using evolutionary computing

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Volumn 7492 LNCS, Issue PART 2, 2012, Pages 468-477

  Allmendinger, Richard ^a   Simaria, Ana S ^a   Farid, Suzanne S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY PURIFICATION; BIOPHARMACEUTICALS; COMBINATORIAL OPTIMIZATION PROBLEMS; EVOLUTIONARY COMPUTING; FITNESS EVALUATIONS; MONTE CARLO TRIALS; MULTIPLE CONSTRAINT; POPULATION SIZES; PURIFICATION PROCESS; REAL-WORLD OPTIMIZATION; UNCERTAIN PARAMETERS;

COMBINATORIAL OPTIMIZATION; EVOLUTIONARY ALGORITHMS; POPULATION STATISTICS; PURIFICATION;

CHROMATOGRAPHY;

EID: 84866404200     PISSN: 03029743     EISSN: 16113349     Source Type: Book Series    
DOI: 10.1007/978-3-642-32964-7_47     Document Type: Conference Paper

References (8)

1. Langer, E.: Downstream factors that will continue to constrain manufacturing through 2013. BioProcessing Journal 8(4), 22-26 (2009)
2. Kelley, B.: Industrialization of mAb production technology: The bioprocessing industry at a crossroads. MAbs 1(5), 443-452 (2009)
3. Joseph, J.R., Sinclair, A., Tichener-Hooker, N.J., Zhou, Y.: A framework for assessing the solutions in chromatographic process design and operation for large-scale manufacture. Journal of Chemical Technology and Biotechnology 81, 1009-1020 (2006)
4. Chhatre, S., Thillaivinayagalingam, P., Francis, R., Titchener-Hooker, N.J., Newcombe, A., Keshavarz-Moore, E.: Decision-Support Software for the Industrial-Scale Chromatographic Purification of Antibodies. Biotechnology Progress 23, 88-894 (2007)
5. Stonier, A., Smith, M., Hutchinson, N., Farid, S.S.: Dynamic simulation framework for design of lean biopharmaceutical manufacturing operations. Computer Aided Chemical Engineering 26, 1069-1073 (2009)
6. Knowles, J.: Closed-Loop Evolutionary Multiobjective Optimization. IEEE Computational Intelligence Magazine 4(3), 77-91 (2009)
7. Allmendinger, R.: Tuning Evolutionary Search for Closed-Loop Optimization. PhD thesis, University of Manchester, Manchester, UK (2012)
8. Farid, S.S., Washbrook, J., Titchener-Hooker, N.J.: Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma. Computers & Chemical Engineering 31, 1141-1158 (2007)