The complex genetics of atrial fibrillation

Journal of the American College of Cardiology

Volumn 60, Issue 13, 2012, Pages 1182-1184

  Judge, Daniel P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

atrial fibrillation; genetics; mutation; polymorphism

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ATRIAL NATRIURETIC FACTOR; DNA; NUCLEOPORIN; SODIUM CHANNEL;

CLINICAL PRACTICE; DEFIBRILLATOR; DNA SEQUENCE; GENETIC ANALYSIS; GENETIC VARIABILITY; HEART ATRIUM FIBRILLATION; HEART FAILURE; HUMAN; HUMAN GENOME; NOTE; PACEMAKER; PRIORITY JOURNAL; PYROSEQUENCING; REGULATORY SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

EID: 84866358038     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.04.031     Document Type: Editorial

References (30)

1. A.S. Go, E.M. Hylek, K.A. Phillips Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study JAMA 285 2001 2370 2375
2. W.B. Kannel, P.A. Wolf, E.J. Benjamin, D. Levy Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates Am J Cardiol 82 Suppl 1998 2N 9N
3. A.J. Camm, P. Kirchhof, G.Y. Lip Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) Eur Heart J 31 2010 2369 2429
4. F.N. Brand, R.D. Abbott, W.B. Kannel, P.A. Wolf Characteristics and prognosis of lone atrial fibrillation 30-year follow-up in the Framingham study JAMA 254 1985 3449 3453
5. J.S. Healey, S.J. Connolly, M.R. Gold Subclinical atrial fibrillation and the risk of stroke N Engl J Med 366 2012 120 129
6. Y.H. Chen, S.J. Xu, S. Bendahhou KCNQ1 gain-of-function mutation in familial atrial fibrillation Science 299 2003 251 254
7. T.M. Olson, A.E. Alekseev, X.K. Liu Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation Hum Mol Genet 15 2006 2185 2191
8. L.S. Ravn, Y. Aizawa, G.D. Pollevick Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation Heart Rhythm 5 2008 427 435
9. M. Xia, Q. Jin, S. Bendahhou A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation Biochem Biophys Res Commun 332 2005 1012 1019
10. Y. Yang, M. Xia, Q. Jin Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation Am J Hum Genet 75 2004 899 905
11. M.S. Olesen, T. Jespersen, J.B. Nielsen Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation Cardiovasc Res 89 2011 786 793
12. D. Darbar, P.J. Kannankeril, B.S. Donahue Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation Circulation 117 2008 1927 1935
13. T.M. Olson, A.E. Alekseev, C. Moreau KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation Nat Clin Pract Cardiovasc Med 4 2007 110 116
14. R.C. Wirka, S. Gore, D.R. Van Wagoner A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation Circ Arrhythm Electrophysiol 4 2011 87 93
15. D.M. Hodgson-Zingman, M.L. Karst, L.V. Zingman Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation N Engl J Med 359 2008 158 165
16. H. Watanabe, D. Darbar, D.W. Kaiser Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation Circ Arrhythm Electrophysiol 2 2009 268 275
17. X. Zhang, S. Chen, S. Yoo Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death Cell 135 2008 1017 1027
18. D.F. Gudbjartsson, D.O. Arnar, A. Helgadottir Variants conferring risk of atrial fibrillation on chromosome 4q25 Nature 448 2007 353 357
19. S. Kaab, D. Darbar, C. van Noord Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation Eur Heart J 30 2009 813 819
20. M.D. Ritchie, S. Rowan, G. Kucera Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation J Am Coll Cardiol 60 2012 1173 1181
21. I.E. Christophersen, L.S. Ravn, E. Budtz-Joergensen Familial aggregation of atrial fibrillation: a study in Danish twins Circ Arrhythm Electrophysiol 2 2009 378 383
22. E.R. Behr, C. Dalageorgou, M. Christiansen Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families Eur Heart J 29 2008 1670 1680
23. NHLBI Exome Sequencing Project (ESP), Exome Variant Server http://evs.gs.washington.edu/EVS/ Accessed June 2012
24. D.J. Tester, C. Valdivia, C. Harris-Kerr Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation Heart Rhythm 7 2010 912 919
25. L.Y. Chen, J.D. Ballew, K.J. Herron, R.J. Rodeheffer, and T.M. Olson A common polymorphism in SCN5A is associated with lone atrial fibrillation Clin Pharmacol Ther 81 2007 35 41
26. S.A. Lubitz, M.F. Sinner, K.L. Lunetta Independent susceptibility markers for atrial fibrillation on chromosome 4q25 Circulation 122 2010 976 984
27. E. Lozano-Velasco, A. Contreras, C. Crist, F. Hernandez-Torres, D. Franco, A.E. Aranega Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis Dev Biol 357 2011 165 178
28. E.V. Semina, R. Reiter, N.J. Leysens Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome Nat Genet 14 1996 392 399
29. G.D. Zakaib Chip chips away at the cost of a genome Nature 475 2011 278
30. M.J. Ackerman, S.G. Priori, S. Willems HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies Heart Rhythm 8 2011 1308 1339