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Volumn 72, Issue 18, 2012, Pages 4818-4828

CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; CCN PROTEIN; CCN6 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; SHORT HAIRPIN RNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

EID: 84866356504     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-0154     Document Type: Article
Times cited : (62)

References (43)
  • 2
    • 67049145082 scopus 로고    scopus 로고
    • Regulatory role of CCN3 in melanoma cell interaction with the extracellular matrix
    • Vallacchi V, Rodolfo M. Regulatory role of CCN3 in melanoma cell interaction with the extracellular matrix. Cell Adh Migr 2009;3:7-10.
    • (2009) Cell Adh Migr , vol.3 , pp. 7-10
    • Vallacchi, V.1    Rodolfo, M.2
  • 3
    • 53149092430 scopus 로고    scopus 로고
    • The CCN family of proteins: Structure-function relationships
    • Holbourn KP, Acharya KR, Perbal B. The CCN family of proteins: structure-function relationships. Trends Biochem Sci 2008;33:461-73.
    • (2008) Trends Biochem Sci , vol.33 , pp. 461-473
    • Holbourn, K.P.1    Acharya, K.R.2    Perbal, B.3
  • 4
    • 82455198983 scopus 로고    scopus 로고
    • Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
    • Jun JI, Lau LF. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 2011;10:945-63.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 945-963
    • Jun, J.I.1    Lau, L.F.2
  • 5
    • 37549015508 scopus 로고    scopus 로고
    • The CCN3 protein and cancer
    • Perbal B. The CCN3 protein and cancer. Adv Exp Med Biol 2006;587:23-40.
    • (2006) Adv Exp Med Biol , vol.587 , pp. 23-40
    • Perbal, B.1
  • 6
    • 33645231002 scopus 로고    scopus 로고
    • CCN proteins and cancer: Two to tango
    • Bleau AM, Planque N, Perbal B. CCN proteins and cancer: two to tango. Front Biosci 2005;10:998-1009.
    • (2005) Front Biosci , vol.10 , pp. 998-1009
    • Bleau, A.M.1    Planque, N.2    Perbal, B.3
  • 7
    • 42049085877 scopus 로고    scopus 로고
    • Inhibition of CCN6(Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1
    • Huang W, Zhang Y, Varambally S, Chinnaiyan AM, Banerjee M, Merajver SD, et al. Inhibition of CCN6(Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. Am J Pathol 2008;172:893-904.
    • (2008) Am J Pathol , vol.172 , pp. 893-904
    • Huang, W.1    Zhang, Y.2    Varambally, S.3    Chinnaiyan, A.M.4    Banerjee, M.5    Merajver, S.D.6
  • 8
    • 2142646419 scopus 로고    scopus 로고
    • WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer
    • Kleer CG, Zhang Y, Pan Q, Merajver SD. WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia 2004;6:179-85.
    • (2004) Neoplasia , vol.6 , pp. 179-185
    • Kleer, C.G.1    Zhang, Y.2    Pan, Q.3    Merajver, S.D.4
  • 9
    • 85047695306 scopus 로고    scopus 로고
    • WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
    • Kleer CG, Zhang Y, Pan Q, van Golen KL,WuZF, Livant D, et al. WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene 2002;21:3172-80.
    • (2002) Oncogene , vol.21 , pp. 3172-3180
    • Kleer, C.G.1    Zhang, Y.2    Pan, Q.3    Van Golen, K.L.4    Wu, Z.F.5    Livant, D.6
  • 10
    • 67651151237 scopus 로고    scopus 로고
    • Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis
    • Franzen CA, Chen CC, Todorovic V, Juric V, Monzon RI, Lau LF. Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Mol Cancer Res 2009;7:1045-55.
    • (2009) Mol Cancer Res , vol.7 , pp. 1045-1055
    • Franzen, C.A.1    Chen, C.C.2    Todorovic, V.3    Juric, V.4    Monzon, R.I.5    Lau, L.F.6
  • 11
    • 47049116948 scopus 로고    scopus 로고
    • Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 upregulation in Cyr61/CCN1-induced gastric cancer cell invasion
    • Lin MT, Kuo IH, Chang CC, Chu CY, Chen HY, Lin BR, et al. Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 upregulation in Cyr61/CCN1-induced gastric cancer cell invasion. J Biol Chem 2008;283:15807-15.
    • (2008) J Biol Chem , vol.283 , pp. 15807-15815
    • Lin, M.T.1    Kuo, I.H.2    Chang, C.C.3    Chu, C.Y.4    Chen, H.Y.5    Lin, B.R.6
  • 12
    • 0032835343 scopus 로고    scopus 로고
    • A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype
    • van Golen KL, Davies S, Wu ZF, Wang Y, Bucana CD, Root H, et al. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res 1999;5:2511-9.
    • (1999) Clin Cancer Res , vol.5 , pp. 2511-2519
    • Van Golen, K.L.1    Davies, S.2    Wu, Z.F.3    Wang, Y.4    Bucana, C.D.5    Root, H.6
  • 13
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 14
    • 77954862083 scopus 로고    scopus 로고
    • The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells
    • Taylor MA, Parvani JG, Schiemann WP. The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia 2010;15:169-90.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 169-190
    • Taylor, M.A.1    Parvani, J.G.2    Schiemann, W.P.3
  • 15
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009;19:156-72.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 17
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-84.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 18
    • 77649178841 scopus 로고    scopus 로고
    • The TAK1-TRAF6 signalling pathway
    • Landstrom M. The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol 2010;42:585-9.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 585-589
    • Landstrom, M.1
  • 19
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci 2005;118:3573-84.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 20
    • 52049111663 scopus 로고    scopus 로고
    • TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
    • Yamashita M, Fatyol K, Jin C, Wang X, Liu Z, Zhang YE. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell 2008;31:918-24.
    • (2008) Mol Cell , vol.31 , pp. 918-924
    • Yamashita, M.1    Fatyol, K.2    Jin, C.3    Wang, X.4    Liu, Z.5    Zhang, Y.E.6
  • 22
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003;30:256-68.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 23
    • 0034010982 scopus 로고    scopus 로고
    • BMP-binding modules in chordin: A model for signalling regulation in the extracellular space
    • Larrain J, Bachiller D, Lu B, Agius E, Piccolo S, De Robertis EM. BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. Development 2000;127:821-30.
    • (2000) Development , vol.127 , pp. 821-830
    • Larrain, J.1    Bachiller, D.2    Lu, B.3    Agius, E.4    Piccolo, S.5    De Robertis, E.M.6
  • 24
    • 0030598867 scopus 로고    scopus 로고
    • Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
    • Piccolo S, Sasai Y, Lu B, De Robertis EM. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 1996;86:589-98.
    • (1996) Cell , vol.86 , pp. 589-598
    • Piccolo, S.1    Sasai, Y.2    Lu, B.3    De Robertis, E.M.4
  • 25
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003;100:11606-11.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 27
    • 0004222021 scopus 로고    scopus 로고
    • Rosen's breast pathology
    • Rosen P, editor. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins
    • Rosen PP. Rosen's breast pathology. In: Rosen P, editor. Rosen's breast pathology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. p. 325.
    • (2008) Rosen's Breast Pathology , pp. 325
    • Rosen, P.P.1
  • 28
    • 0030320654 scopus 로고    scopus 로고
    • The importance of the microenvironment in breast cancer progression: Recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay
    • Weaver VM, Fischer AH, Peterson OW, Bissell MJ. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol 1996;74:833-51.
    • (1996) Biochem Cell Biol , vol.74 , pp. 833-851
    • Weaver, V.M.1    Fischer, A.H.2    Peterson, O.W.3    Bissell, M.J.4
  • 29
    • 79956105716 scopus 로고    scopus 로고
    • CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
    • Lorenzatti G, Huang W, Pal A, Cabanillas AM, Kleer CG. CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. J Cell Sci 2011;124:1752-8.
    • (2011) J Cell Sci , vol.124 , pp. 1752-1758
    • Lorenzatti, G.1    Huang, W.2    Pal, A.3    Cabanillas, A.M.4    Kleer, C.G.5
  • 30
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002;4:599-604.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 31
    • 54449100051 scopus 로고    scopus 로고
    • BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis
    • Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, et al. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ Res 2008;103:804-12.
    • (2008) Circ Res , vol.103 , pp. 804-812
    • Heinke, J.1    Wehofsits, L.2    Zhou, Q.3    Zoeller, C.4    Baar, K.M.5    Helbing, T.6
  • 32
    • 0043133835 scopus 로고    scopus 로고
    • BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation
    • Moser M, Binder O,WuY, Aitsebaomo J, Ren R, Bode C, et al.BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol 2003;23:5664-79.
    • (2003) Mol Cell Biol , vol.23 , pp. 5664-5679
    • Moser, M.1    Binder, O.2    Wu, Y.3    Aitsebaomo, J.4    Ren, R.5    Bode, C.6
  • 34
    • 1642523489 scopus 로고    scopus 로고
    • Helix-loop-helix proteins in mammary gland development and breast cancer
    • Desprez PY, Sumida T, Coppe JP. Helix-loop-helix proteins in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2003;8:225-39.
    • (2003) J Mammary Gland Biol Neoplasia , vol.8 , pp. 225-239
    • Desprez, P.Y.1    Sumida, T.2    Coppe, J.P.3
  • 35
    • 0033531948 scopus 로고    scopus 로고
    • Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein-and activin-mediated growth arrest and apoptosis in B cells
    • Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, et al. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein-and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem 1999;274:13637-42.
    • (1999) J Biol Chem , vol.274 , pp. 13637-13642
    • Ishisaki, A.1    Yamato, K.2    Hashimoto, S.3    Nakao, A.4    Tamaki, K.5    Nonaka, K.6
  • 36
    • 33845906843 scopus 로고    scopus 로고
    • All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
    • Leask A, Abraham DJ. All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 2006;119:4803-10.
    • (2006) J Cell Sci , vol.119 , pp. 4803-4810
    • Leask, A.1    Abraham, D.J.2
  • 37
    • 34948831652 scopus 로고    scopus 로고
    • The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling
    • Nakamura Y, Weidinger G, Liang JO, Aquilina-Beck A, Tamai K, Moon RT, et al. The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest 2007;117:3075-86.
    • (2007) J Clin Invest , vol.117 , pp. 3075-3086
    • Nakamura, Y.1    Weidinger, G.2    Liang, J.O.3    Aquilina-Beck, A.4    Tamai, K.5    Moon, R.T.6
  • 38
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995;9:2105-16.
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 39
    • 79961006281 scopus 로고    scopus 로고
    • Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
    • McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, et al. Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J Clin Invest 2011;121:3206-19.
    • (2011) J Clin Invest , vol.121 , pp. 3206-3219
    • McLean, K.1    Gong, Y.2    Choi, Y.3    Deng, N.4    Yang, K.5    Bai, S.6
  • 40
    • 12544259720 scopus 로고    scopus 로고
    • Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration
    • Rothhammer T, Poser I, Soncin F, Bataille F, Moser M, Bosserhoff AK. Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Cancer Res 2005;65:448-56.
    • (2005) Cancer Res , vol.65 , pp. 448-456
    • Rothhammer, T.1    Poser, I.2    Soncin, F.3    Bataille, F.4    Moser, M.5    Bosserhoff, A.K.6
  • 41
    • 0141594935 scopus 로고    scopus 로고
    • From developmental disorder to heritable cancer: It's all in the BMP/TGF-beta family
    • Waite KA, Eng C. From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family. Nat Rev Genet 2003;4:763-73.
    • (2003) Nat Rev Genet , vol.4 , pp. 763-773
    • Waite, K.A.1    Eng, C.2
  • 42
    • 84863419728 scopus 로고    scopus 로고
    • TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers
    • Singh A, Sweeney MF, Yu M, Burger A, Greninger P, Benes C, et al. TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers. Cell 2012;148:639-50.
    • (2012) Cell , vol.148 , pp. 639-650
    • Singh, A.1    Sweeney, M.F.2    Yu, M.3    Burger, A.4    Greninger, P.5    Benes, C.6


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