Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

Molecular Biology of the Cell

Volumn 23, Issue 18, 2012, Pages 3707-3721

  Sakuma, Megumi ^a   Shirai, Yasuhito ^a   Yoshino, Ken Ichi ^a   Kuramasu, Maho ^a   Nakamura, Tomofumi ^a   Yanagita, Toshihiko ^b   Mizuno, Kensaku ^c   Hide, Izumi ^d   Nakata, Yoshihiro ^d   Saito, Naoaki ^a  

^a KOBE UNIVERSITY   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; AZELASTINE; COFILIN; F ACTIN; IONOMYCIN; PROTEIN KINASE C ALPHA; RUBOXISTAURIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CONTROLLED STUDY; DEGRANULATION; DEPOLYMERIZATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HISTAMINE RELEASE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION;

14-3-3 PROTEINS; ACTINS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL DEGRANULATION; CELL LINE, TUMOR; COFILIN 1; ENZYME INHIBITORS; GREEN FLUORESCENT PROTEINS; HISTAMINE RELEASE; IMMUNOBLOTTING; INDOLES; MALEIMIDES; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; POLYMERIZATION; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; RATS; RNA INTERFERENCE; SERINE;

RATTUS;

EID: 84866355657     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-01-0053     Document Type: Article

References (16)

1. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998). Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393, 805-809. (Pubitemid 28299494)
2. Bamburg JR (1999). Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu Rev Cell Dev Biol 15, 185-230.
3. Barsumian EL, Isersky C, Petrino MG, Siraganian RP (1981). IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones. Eur J Immunol 11, 317-323. (Pubitemid 11112996)
4. Befus AD, Pearce FL, Gauldie J, Horsewood P, Bienenstock J (1982). Mucosal mast cells. Isolation and functional characteristics of rat intestinal mast cells. J Immunol 128, 2475-2480. (Pubitemid 12124464)
5. Blank U, Rivera J (2004). The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol 25, 266-273. (Pubitemid 38501673)
6. Burgoyne RD, Cheek TR (1985). Is the transient nature of the secretory response of chromaffin cells due to inactivation of calcium channels?. FEBS Lett 182, 115-118. (Pubitemid 15094703)
7. Bretscher A, Edwards K, Fehon RG (2002). ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 3, 586-599.
8. Carlier MF, Laurent V, Santolini J, Melki R, Didry D, Xia GX, Hong Y, Chua NH, Pantaloni D (1997). Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J Cell Biol 136, 1307-1322. (Pubitemid 27421917)
9. Frigeri L, Apgar JR (1999). The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells. J Immunol 162, 2243-2250. (Pubitemid 29288847)
10. Fu H, Subramarian RR, Masters SC (2000). 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol 40, 617-647. (Pubitemid 30340695)
11. Galli SJ (2000). Mast cells and basophils. Curr Opin Hematol 7, 32-39.
12. Gohla A, Bokoch G (2002). 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Cur Biol 12, 1704-1710. (Pubitemid 35161927)
13. Hanson DA, Ziegler SF (2002). Regulation of ionomycin-mediated granule release from rat basophil leukemia cells. Mol Immunol 38, 1329-1335. (Pubitemid 35253772)
14. Hide I, Toriu N, Nuibe T, Inoue A, Hide M, Yamamoto S, Nakata Y (1997). Suppression of TNF-α secretion by azelastin in a rat mast (RBL-2H3) cell line. J Immunol 159, 2932-2940.
15. Hultsch T, Brand P, Lohman S, Saloga J, Kincaid RL, Knop J (1998). Direct evidence that FK506 inhibition of FcεRI-mediated exocytosis from RBL cells involves calcineurin. Arch Dermatol Res 290, 258-263. (Pubitemid 28301552)
16. Ichetovkin I, Han J, Pang KM, Knecht DA, Condeelis JS (2000). Actin filaments are