Melanoregulin is stably targeted to the melanosome membrane by palmitoylation

Biochemical and Biophysical Research Communications

Volumn 426, Issue 2, 2012, Pages 209-214

  Wu, Xufeng S ^a   Martina, Jose A ^a   Hammer, John A ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Dilute suppressor; Melanoregulin; Melanosome; Palmitoylation

Indexed keywords

CYSTEINE; GREEN FLUORESCENT PROTEIN; MELANOREGULIN; PALMITIC ACID; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; ISOTOPE LABELING; LYSOSOME; MELANOCYTE; MELANOSOME; MEMBRANE; MOUSE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS;

ANIMALS; CARRIER PROTEINS; CELL LINE; INTRACELLULAR MEMBRANES; LIPOYLATION; MELANOCYTES; MELANOSOMES; MICE; PROTEIN STABILITY;

ANIMALIA; MAMMALIA; MUS;

EID: 84866344071     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.064     Document Type: Article

References (16)

1. Wu X., Bowers B., Rao K., Wei Q., Hammer J.A. Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function In vivo. J. Cell. Biol. 1998, 143:1899-1918.
2. O'Sullivan T.N., Wu X.S., Rachel R.A., Huang J.D., Swing D.A., Matesic L.E., Hammer J.A., Copeland N.G., Jenkins N.A. Dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice. Proc. Natl. Acad. Sci. USA 2004, 101:16831-16836.
3. Wu X.S., Masedunskas A., Weigert R., Copeland N.G., Jenkins N.A., Hammer J.A. Melanoregulin regulates a shedding mechanism that drives melanosome transfer from melanocytes to keratinocytes. Proc. Natl. Acad. Sci. USA 2012, 109:E2101-E2109.
4. Ohbayashi N., Maruta Y., Ishida M., Fukuda M. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J. Cell Sci. 2012, 125:1508-1518.
5. Moore K.J., Swing D.A., Copeland N.G., Jenkins N.A. The murine dilute suppressor gene encodes a cell autonomous suppressor. Genetics 1994, 138:491-497.
6. M.D. Resh, Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE 2006, 2006, re14.
7. Resh M.D. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 1999, 1451:1-16.
8. Seperack P.K., Mercer J.A., Strobel M.C., Copeland N.G., Jenkins N.A. Retroviral sequences located within an intron of the dilute gene alter dilute expression in a tissue-specific manner. EMBO J. 1995, 14:2326-2332.
9. Damek-Poprawa M., Diemer T., Lopes V.S., Lillo C., Harper D.C., Marks M.S., Wu Y., Sparrow J.R., Rachel R.A., Williams D.S., Boesze-Battaglia K. Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. J. Biol. Chem. 2009, 284:10877-10889.
10. Martina J.A., Lelouvier B., Puertollano R. The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. Traffic 2009, 10:1143-1156.
11. Resh M.D. Use of analogs and inhibitors to study the functional significance of protein palmitoylation. Methods 2006, 40:191-197.
12. Greaves J., Salaun C., Fukata Y., Fukata M., Chamberlain L.H. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem 2008, 283:25014-25026.
13. Jordens I., Westbroek W., Marsman M., Rocha N., Mommaas M., Huizing M., Lambert J., Naeyaert J.M., Neefjes J. Rab7 and Rab27a control two motor protein activities involved in melanosomal transport. Pigment Cell Res. 2006, 19:412-423.
14. Johansson M., Rocha N., Zwart W., Jordens I., Janssen L., Kuijl C., Olkkonen V.M., Neefjes J. Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betaIII spectrin. J Cell Biol 2007, 176:459-471.
15. Levental I., Grzybek M., Simons K. Greasing their way: lipid modifications determine protein association with membrane rafts. Biochemistry 2010, 49:6305-6316.
16. Lebrand C., Corti M., Goodson H., Cosson P., Cavalli V., Mayran N., Faure J., Gruenberg J. Late endosome motility depends on lipids via the small GTPase Rab7. EMBO J 2002, 21:1289-1300.