Combined effect of Coccinia indica (Wight & Arn) and Salvadora oleoides (Decne) on blood glucose level and other risk factors associated with type 2 diabetes mellitus in alloxan induced diabetic rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue SUPPL. 4, 2012, Pages 79-84

  Saklani, Akanksha ^a   Parcha, Versha ^a   Dhulia, Ishan ^a   Kumar, Deepak ^b  

^a Sardar Bhagwan Singh Post Gratudate Institute of Biomedical Sciences & Research   (India)

^b Dolphin (PG) Institute of Biomedical and Natural Sciences   (India)

Author keywords

Alloxan; Antidiabetic; Coccinia indica; Diabetes mellitus; Glipizide; Salvadora oleoides

Indexed keywords

ALANINE AMINOTRANSFERASE; ALLOXAN; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; COCCINIA INDICA EXTRACT; CREATININE; GLIPIZIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; SALVADORA OLEOIDES EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; COCCINIA INDICA; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT LEAF; RAT; RISK FACTOR; SALVADORA OLEOIDES; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

EID: 84866339838     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabetic Medicine, 1997; 14 (Suppl 5):S1-85.
2. Ramachandran A, Snehalatha C, Vijay V. Burden of type 2 diabetes and its complications-The Indian scenario. Curr. Sci.,2002;83: 1471-76.
3. Bajaj JS, Madan R. Diabetes in tropics and developing countries. IDF bull. 1993; 38 (2): 5-6.
4. David MN. The pathophysiology of diabetic complications: How much does the glucose hypothesis explain? Ann. Intern. Med. 1996; 174 (1pt): 286-289.
5. Chandel HS, Pathak A and Tailang M. Polyherbal Formulations for Antidiabetic Therapy. IJPPS, 2011; 3 (Suppl 3): 226-228.
6. Mandlik RV, Desai SK, &Naik SR. Antidiabetic activity of a polyherbal formulation (DRF/AY/5001); Indian J. Exp. Biol., 2008; 46: 599-606.
7. Pavana P, Sethupathy S and Manoharan S. Antihyperglycemic and antilipidperoxidative effects of Tephrosiapurpurea seed extract in streptozotocin induced diabetic rats; Indian J. Clin. Biochem.,2007;22 (1): 77-83.
8. AfiaAM, Mamunur R, Mir Imam IW, Robiul IM, Sharif MS, ArifullMd, et al. Comparison of Long-term Antihyperglycemic and Hypolipidemic Effects between Coccinia cordifolia (Linn.) and Catharanthusroseus (Linn.) in Alloxan-induced diabetic Rats. Res. J. Med. Med. Sci. 2007;2: 29-34.
9. Purintapiban J, Keawpradub N &Jansakul C. Role of the water extract from Coccinia indica stem on the stimulation of glucose transport in L8 myotubes. Songklanakarin J. Sci. Technol. 2006;28(6): 1199-1208.
10. Yadav JP, Saini S, KaliaAN &Dangi AS. Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats. Indian J Pharmacol.,2008;40 (1): 23-27.
11. Kumar D, Parcha V, Dhulia I and Maithani A. Evaluation of Anti-hyperlipidemic activity of methanol extract of Salvadora oleoides (Linn.) leaves in Triton WR-1339 (Tyloxapol) induced hyperlipidemic rats, JPR,2011;4 (2): 512-13.
12. Litchfield JT Jr, and Wilcoxon F. A simplified method of evaluating dose effect, J. Pharmac. exp. Ther, 1949;96(2): 99-113.
13. Srinivasan K &Ramarao P. Animal models in type 2 diabetes research: An overview; Indian J Med Res 2007;125: 451-472.
14. William TF, Robert IL, and Donald SF. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem., 1972; 18 (6): 499-502.
15. Winer N and Sowers JR. Epidemiology of diabetes. J. Clin. Pharmacol. 2004, 44: 397-405.
16. Schalkwijk CG &Stehouwer CDA. Vascular Complications in diabetes mellitus: the role of endothelial dysfunction. Clin. Sci.,2005; 109: 143-159.
17. Bastaki S. Diabetes mellitus & its treatment-Review. Int J Diabetes & Metabolism2005; 13: 111-134.
18. Rout SP, Choudary KA, Kar DM, Das L & Jain A. Plants in Traditional Medicinal System-Future Source of New Drugs. IJPPS, 2009, 1 (1): 1-23.
19. Lenzen S. The mechanisms of alloxan-and streptozotocin induced diabetes. Diabetologia2008; 51: 216-226.
20. Venkateswaran S, Pari L. Effect of Coccinia indica on blood glucose, insulin and hepatic key enzymes in experimental diabetes. PharmaceuticalBiology2002; 40 (3): 165-170.
21. Gold AH. The effect of diabetes and insulin on liver glycogen synthetase activation. J BiolChem1970; 245: 903-5.
22. Balasse EO, Bier DM, Havel RJ. Early effects of anti-insulin serum on hepatic metabolism of plasma free fatty acids in dogs. Diabetes1972;21: 280-4.
23. Thakkar NV, Patel JA. Pharmacological evaluation of "Glyoherb": A poly herbal formulation on streptozotocin-induced diabetic rats. Int J DiabDevCtries.2010; 30 (1): 1-7.
24. Kanungo SK, Panda DS, Swain SR, Barik BB and Tripathi DK. Comparative Evaluation ofHypolipidemic Activity of Some Marketed Herbal Formulations in Triton Induced Hyperlipidemic Rats. Pharmacologyonline2007; 3: 211-221.
25. Odetola AA, Akinloye O, Egunjobi C, Adekunle WA, Ayoola AO. Possible antidiabetic and antihyperlipidaemic effect of fermented Parkiabiglobosa (JACQ) extract in alloxan-induced diabetic rats. ClinExpPharmacolPhysiol2006; 33: 808-12.
26. Fernandes NP, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordicacharantia fruit extract. BMC ComplAltern Med 2007; 7: 29-37.
27. Ramalingam S, Pari L. Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC Complement Altern Med2005; 5: 14-23.
28. Felig P, Marlise E, Ohman JL, Cahil CF Jr. Plasma amino acid levels in diabetic ketoacidosis. Diabetes1970; 19: 727-8.