Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes

Leukemia Research

Volumn 36, Issue 11, 2012, Pages 1434-1437

  Noy, Peter ^a   Gaston, Kevin ^b   Jayaraman, Padma Sheela ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

BCR ABL; Leukaemia; Phosphorylation; Transcription

Indexed keywords

BCR ABL PROTEIN; CASEIN KINASE II; DASATINIB; IMATINIB; MESSENGER RNA; PROLINE RICH PROTEIN; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HHEX; TRANSCRIPTION FACTOR PRH; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; XRCC1 PROTEIN;

ARTICLE; CELL COUNT; CELL SURVIVAL; ENZYME ACTIVITY; GENE EXPRESSION; GENE REPRESSION; HUMAN; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PYRIMIDINES; SIGNAL TRANSDUCTION; THIAZOLES; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866328537     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.07.013     Document Type: Article

References (8)

1. Kim J.S., Eom J.I., Cheong J.W., Choi A.J., Lee J.K., Yang W.I., et al. Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia. Clin Cancer Res 2007, 13(February (3)):1019-1028.
2. Phan-Dinh-Tuy F., Henry J., Boucheix C., Perrot J.Y., Rosenfeld C., Kahn A. Protein kinases in human leukemic cells. Am J Hematol 1985, 19(July (3)):209-218.
3. Donella-Deana A., Cesaro L., Sarno S., Ruzzene M., Brunati A.M., Marin O., et al. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochem J 2003, 372(June (Pt 3)):841-849.
4. Mishra S., Reichert A., Cunnick J., Senadheera D., Hemmeryckx B., Heisterkamp N., et al. Protein kinase CKIIalpha interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells. Oncogene 2003, 22(November (51)):8255-8262.
5. Soufi A., Jayaraman P.S. PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate. Biochem J 2008, 412(June (3)):399-413.
6. Noy P., Williams H., Sawasdichai A., Gaston K., Jayaraman P.S. PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Mol Cell Biol 2010, 30(May (9)):2120-2134.
7. Soufi A., Noy P., Buckle M., Sawasdichai A., Gaston K., Jayaraman P.S. CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. Nucleic Acids Res 2009, 37(March):3288-3300.
8. Janowska-Wieczorek A., Majka M., Marquez-Curtis L., Wertheim J.A., Turner A.R., Ratajczak M.Z. Bcr-abl-positive cells secrete angiogenic factors including matrix metalloproteinases and stimulate angiogenesis in vivo in Matrigel implants. Leukemia 2002, 16(June (6)):1160-1166.