Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: Its assessment by cardiac magnetic resonance

Cardiovascular Diabetology

Volumn 11, Issue , 2012, Pages

  Kim, Hyun M ^a   Kim, Kwang J ^a   Lee, Hye Jeong ^a   Yu, Hee T ^b   Moon, Jae H ^c   Kang, Eun S ^a   Cha, Bong S ^a   Lee, Hyun C ^a   Lee, Byung Wan ^a   Kim, Young J ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

Author keywords

Cardiovascular magnetic resonance; Coronary artery stenosis; Epicardial adipose tissue; Silent ischemia; Type 2 diabetes

Indexed keywords

HEMOGLOBIN A1C; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD VESSEL DIAMETER; BODY MASS; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR RISK; CORONARY ARTERY OBSTRUCTION; CORRELATION ANALYSIS; DIABETIC PATIENT; DIET RESTRICTION; EPICARDIUM; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HEART INFARCTION; HUMAN; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; SILENT MYOCARDIAL ISCHEMIA; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; WAIST HIP RATIO;

ADIPOSE TISSUE; ASYMPTOMATIC DISEASES; BIOLOGICAL MARKERS; CORONARY STENOSIS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL ISCHEMIA; ODDS RATIO; PERICARDIUM; PREDICTIVE VALUE OF TESTS; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84866326744     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-11-83     Document Type: Article

References (37)

1. Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2005, 2:536-543. 10.1038/ncpcardio0319, 16186852.
2. Verhagen SN, Visseren FL. Perivascular adipose tissue as a cause of atherosclerosis. Atherosclerosis 2011, 214:3-10. 10.1016/j.atherosclerosis.2010.05.034, 20646709.
3. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, Johnson AG, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003, 108:2460-2466. 10.1161/01.CIR.0000099542.57313.C5, 14581396.
4. Baker AR, Silva NF, Quinn DW, Harte AL, Pagano D, Bonser RS, Kumar S, McTernan PG. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol 2006, 5:1. 10.1186/1475-2840-5-1, 1352345, 16412224.
5. Bettencourt N, Toschke AM, Leite D, Rocha J, Carvalho M, Sampaio F, Xara S, Leite-Moreira A, Nagel E, Gama V. Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden. Int J Cardiol 2012, 158:26-32. 10.1016/j.ijcard.2010.12.085, 21255849.
6. Harada K, Amano T, Uetani T, Tokuda Y, Kitagawa K, Shimbo Y, Kunimura A, Kumagai S, Yoshida T, Kato B, et al. Cardiac 64-multislice computed tomography reveals increased epicardial fat volume in patients with acute coronary syndrome. Am J Cardiol 2011, 108:1119-1123. 10.1016/j.amjcard.2011.06.012, 21813107.
7. Oshinski JN, Delfino JG, Sharma P, Gharib AM, Pettigrew RI. Cardiovascular magnetic resonance at 3.0 T: current state of the art. J Cardiovasc Magn Reson 2010, 12:55. 10.1186/1532-429X-12-55, 2964699, 20929538.
8. Ruberg FL, Chen Z, Hua N, Bigornia S, Guo Z, Hallock K, Jara H, LaValley M, Phinikaridou A, Qiao Y, et al. The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome. Obesity (Silver Spring) 2010, 18:1116-1121.
9. Liang KW, Tsai IC, Lee WJ, Lee IT, Lee WL, Lin SY, Wan CJ, Fu CP, Ting CT, Sheu WH. MRI measured epicardial adipose tissue thickness at the right AV groove differentiates inflammatory status in obese men with metabolic syndrome. Obesity (Silver Spring) 2012, 20:525-532.
10. Seon CS, Min KW, Lee SY, Nho KW, Park SH, Koo BK, Han KA. Cardiovascular Risk assessment with vascular function, carotid atherosclerosis and the UKPDS risk engine in Korean patients with newly diagnosed Type 2 Diabetes. Diab Metab J 2011, 35:619-627.
11. Kim HM, Kim KJ, Moon JH, Lee HJ, Chae MK, Chang HJ, Kang ES, Cha BS, Lee HC, Kim YJ, Lee BW. Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients. Acta Diabetol 2011, [Epub ahead of print].
12. Rose GA. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ 1962, 27:645-658. 2555832, 13974778.
13. Denke MA, Pasternak RC. Defining and treating the metabolic syndrome: a primer from the adult treatment panel III. Curr Treat Options Cardiovasc Med 2001, 3:251-253. 10.1007/s11936-001-0087-5, 11445056.
14. Lee SH, Lee BW, Won HK, Moon JH, Kim KJ, Kang ES, Cha BS, Lee HC. Postprandial triglyceride is associated with fasting triglyceride and HOMA-IR in Korean subjects with Type 2 diabetes. Diabetes & metabolism journal 2011, 35:404-410. 10.4093/dmj.2011.35.4.404, 22973497.
15. Wang TD, Lee WJ, Shih FY, Huang CH, Chang YC, Chen WJ, Lee YT, Chen MF. Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat. J Clin Endocrinol Metab 2009, 94:662-669. 10.1210/jc.2008-0834, 19050055.
16. Wang TD, Lee WJ, Shih FY, Huang CH, Chen WJ, Lee YT, Shih TT, Chen MF. Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity. Atherosclerosis 2010, 213:279-287. 10.1016/j.atherosclerosis.2010.07.055, 20801451.
17. de Feyter PJ. Epicardial adipose tissue: an emerging role for the development of coronary atherosclerosis. Clin Cardiol 2011, 34:143-144. 10.1002/clc.20893, 21400540.
18. Zhou Y, Wei Y, Wang L, Wang X, Du X, Sun Z, Dong N, Chen X. Decreased adiponectin and increased inflammation expression in epicardial adipose tissue in coronary artery disease. Cardiovasc Diabetol 2011, 10:2. 10.1186/1475-2840-10-2, 3032658, 21226932.
19. Gao X, Mi S, Zhang F, Gong F, Lai Y, Gao F, Zhang X, Wang L, Tao H. Association of chemerin mRNA expression in human epicardial adipose tissue with coronary atherosclerosis. Cardiovasc Diabetol 2011, 10:87. 10.1186/1475-2840-10-87, 3198902, 21981776.
20. Yorgun H, Canpolat U, Hazirolan T, Ates AH, Sunman H, Dural M, Sahiner L, Kaya EB, Aytemir K, Tokgozoglu L, et al. Increased epicardial fat tissue is a marker of metabolic syndrome in adult patients. Int J Cardiol 2011, [Epub ahead of print].
21. Park JS, Ahn SG, Hwang JW, Lim HS, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH. Impact of body mass index on the relationship of epicardial adipose tissue to metabolic syndrome and coronary artery disease in an Asian population. Cardiovasc Diabetol 2010, 9:29. 10.1186/1475-2840-9-29, 2913996, 20604967.
22. Nelson AJ, Worthley MI, Psaltis PJ, Carbone A, Dundon BK, Duncan RF, Piantadosi C, Lau DH, Sanders P, Wittert GA, Worthley SG. Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume. J Cardiovasc Magn Reson 2009, 11:15. 10.1186/1532-429X-11-15, 2684106, 19416534.
23. Okayama S, Ayako S, Somekawa S, Uemura S, Kubota Y, Saito Y. Feasibility of dual gradient-echo in-phase and opposed-phase magnetic resonance imaging for the evaluation of epicardial fat. Acta Radiol 2011, 52:723-729. 10.1258/ar.2011.100454, 21586607.
24. Sicari R, Sironi AM, Petz R, Frassi F, Chubuchny V, De Marchi D, Positano V, Lombardi M, Picano E, Gastaldelli A. Pericardial rather than epicardial fat is a cardiometabolic risk marker: an MRI vs echo study. J Am Soc Echocardiogr 2011, 24:1156-1162. 10.1016/j.echo.2011.06.013, 21795020.
25. Ahn SG, Lim HS, Joe DY, Kang SJ, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH. Relationship of epicardial adipose tissue by echocardiography to coronary artery disease. Heart 2008, 94:e7. 10.1136/hrt.2007.118471, 17923467.
26. Sarin S, Wenger C, Marwaha A, Qureshi A, Go BD, Woomert CA, Clark K, Nassef LA, Shirani J. Clinical significance of epicardial fat measured using cardiac multislice computed tomography. Am J Cardiol 2008, 102:767-771. 10.1016/j.amjcard.2008.04.058, 18774004.
27. Ishida M, Kato S, Sakuma H. Cardiac MRI in ischemic heart disease. Circ J 2009, 73:1577-1588. 10.1253/circj.CJ-09-0524, 19667487.
28. Klein C, Gebker R, Kokocinski T, Dreysse S, Schnackenburg B, Fleck E, Nagel E. Combined magnetic resonance coronary artery imaging, myocardial perfusion and late gadolinium enhancement in patients with suspected coronary artery disease. J Cardiovasc Magn Reson 2008, 10:45. 10.1186/1532-429X-10-45, 2575198, 18928521.
29. Seeger A, Hennemuth A, Klumpp B, Fenchel M, Kramer U, Bretschneider C, Mangold S, May AE, Claussen CD, Peitgen HO, Miller S. Fusion of MR coronary angiography and viability imaging: feasibility and clinical value for the assignment of myocardial infarctions. Eur J Radiol 2012, 81:71-76. 10.1016/j.ejrad.2010.12.005, 21215542.
30. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003, 88:5163-5168. 10.1210/jc.2003-030698, 14602744.
31. Gorter PM, van Lindert AS, de Vos AM, Meijs MF, van der Graaf Y, Doevendans PA, Prokop M, Visseren FL. Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease. Atherosclerosis 2008, 197:896-903. 10.1016/j.atherosclerosis.2007.08.016, 17884060.
32. Tamarappoo B, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, Friedman JD, Hayes SW, Thomson LE, Slomka PJ, et al. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging 2010, 3:1104-1112. 10.1016/j.jcmg.2010.07.014, 3057558, 21070997.
33. Mattsson C, Olsson T. Estrogens and glucocorticoid hormones in adipose tissue metabolism. Curr Med Chem 2007, 14:2918-2924. 10.2174/092986707782359972, 18045137.
34. Iglesias MJ, Eiras S, Pineiro R, Lopez-Otero D, Gallego R, Fernandez AL, Lago F, Gonzalez-Juanatey JR. Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery. Rev Esp Cardiol 2006, 59:1252-1260. 10.1157/13096596, 17194420.
35. Fei J, Cook C, Blough E, Santanam N. Age and sex mediated changes in epicardial fat adipokines. Atherosclerosis 2010, 212:488-494. 10.1016/j.atherosclerosis.2010.06.044, 2952711, 20667540.
36. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004, 89:2548-2556. 10.1210/jc.2004-0395, 15181022.
37. Iacobellis G, Lonn E, Lamy A, Singh N, Sharma AM. Epicardial fat thickness and coronary artery disease correlate independently of obesity. Int J Cardiol 2011, 146:452-454. 10.1016/j.ijcard.2010.10.117, 21094545.