Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBPβ 3'UTR through competitive binding with HuR

Biochemical and Biophysical Research Communications

Volumn 426, Issue 1, 2012, Pages 122-128

  Sun, Da Quan ^a   Wang, Ying ^a   Liu, Ding Gan ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

C EBP 3'UTR; Competitive binding; Distinct AU rich RNA; HuR; Tumor suppression

Indexed keywords

62NT AU RICH RNA; ANTINEOPLASTIC AGENT; CCAAT ENHANCER BINDING PROTEIN BETA; HUR PROTEIN; MESSENGER RNA; RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; BINDING COMPETITION; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

AU RICH ELEMENTS; BASE SEQUENCE; BINDING, COMPETITIVE; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; CELL PROLIFERATION; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA;

EID: 84866317125     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.049     Document Type: Article

References (24)

1. P.R. Bohjanen, Perspectives on the ARE as it turns 25 years old, Wiley Interdiscip Rev RNA. 2012. [Epub ahead of print]. doi:10.1002/wrna.1125.
2. Chatterjee S., Pal J.K. Role of 5'- and 3'-untranslated regionsof mRNAs in human diseases. Biol. Cell 2009, 101:251-262.
3. Mayr C., Bartel D.P. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 2009, 138:673-684.
4. Basu S.K., Malik R., Huggins C.J., et al. 3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells. EMBO J. 2011, 30:3714-3728.
5. Fan X.C., Myer V.E., Steitz J.A. AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation. Genes Dev. 1997, 11:2557-2568.
6. Khabar K.S. Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements. Cell. Mol. Life Sci. 2010, 67:2937-2955.
7. Barker A., Epis M.R., Porter C.J., et al. Sequence requirements for RNA binding by HuR and AUF1. J. Biochem. 2012, 151:423-437.
8. Ahmed F., Benedito V.A., Zhao P.X. Mining functional elements in messenger RNAs: overview. Challenges, Perspect. Front Plant Sci. 2011, 2:84.
9. Bergalet J., Fawal M., Lopez C., et al. HuR-mediated control of C/EBPbeta mRNA stability and translation in ALK-positive anaplastic large cell lymphomas. Mol. Cancer Res. 2011, 9:485-496.
10. Latorre E., Tebaldi T., Viero G., et al. Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol. Cancer 2012, 11:13.
11. Vázquez-Chantada M., Fernández-Ramos D., Embade N., et al. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology 2010, 138:1943-1953.
12. Mercer T.R., Wilhelm D., Dinger M.E., et al. Expression of distinct RNAs from 3'untranslated regions. Nucleic Acids Res. 2011, 39:2393-2403.
13. Liu D.G., Noda M., Wang D., et al. A cDNA clone with anti-oncogene activity. Sci. China, B. 1992, 35:822-833.
14. Liu D.G., Akira S., Kishimoto T., et al. Overexpression of a reversion-related protein in the revertant RR cells. Sci. China, C: Life Sci. 1996, 39:300-309.
15. Rastinejad F., Conboy M.J., Rando T.A., et al. Tumor suppression by RNA from the 3'untranslated region of a-tropomyosin. Cell 1993, 75:1107-1117.
16. Ishiwatari H., Nakanishi K., Kondoh G., et al. Suppression of tumor growth by the 3'untranslated region of mel-18 in 3Y1 cells transformed by the E6 and E7 genes of human papiloma virus type 18. Cancer Lett. 1997, 117:57-65.
17. Manjeshwar S., Branam D.E., Lerner M.R., et al. Tumor suppression by the prohibitin gene 3'untranslated region RNA in human breast cancer. Cancer Res. 2003, 63:5251-5256.
18. Liu D.-G., Jiang Q.-H., Wei Y.-Y., et al. Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3'UTR. Cell Res. 2003, 13:509-514.
19. Lehman N. RNA in evolution. Wiley Interdiscip. Rev. RNA. 2010, 1:202-213.
20. Wang Y., Sun D.Q., Liu D.G. Tumor suppression by RNA from C/EBPβ 3'UTR through the inhibition of protein kinase Cε activity. PLoS One 2011, 6:e16543.
21. Wang H.-Z., Wang Y., Sun L., et al. Sequences near both termini of the C/EBPβ 3'untranslated region are important for its tumor suppression activity. Acta Biochim. Biophys. Sin. 2009, 41:456-463.
22. Chen C.Y., Shyu A.B. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 1995, 20:465-470.
23. Dong R.C., Zhou R.H., Lu F.D., et al. Establishment of SMMC-7721, a human hepatocarcinoma cell line, and observations on its biological characteristics. J. Second Military Med. Uni. (Shanghai) 1980, 1:5-9.
24. Galbán S., Kuwano Y., Pullmann R., et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol. Cell. Biol. 2008, 18:3-107.