Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation

British Journal of Haematology

Volumn 159, Issue 1, 2012, Pages 78-81

  Ribera, Josep María ^a   García, Olga ^a   Montesinos, Pau ^b   Brunet, Salut ^c   Abella, Eugenia ^d   Barrios, Manuel ^e   González Campos, José ^f   Bravo, Pilar ^g   Amigo, Maria Luz ^h   Hernández Rivas, Jesús María ⁱ  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^f HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^g HOSPITAL UNIVERSITARIO DE FUENLABRADA   (Spain)

^h HOSPITAL MORALES MESEGUER   (Spain)

ⁱ Centro de Investigacion del Cancer   (Spain)

Author keywords

Acute lymphoblastic leukaemia; Imatinib; Philadelphia chromosome

Indexed keywords

CYCLOPHOSPHAMIDE; DAUNORUBICIN; DEXAMETHASONE; IMATINIB; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER MORTALITY; CANCER SURVIVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; EVENT FREE SURVIVAL; FEMALE; HUMAN; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OUTCOME ASSESSMENT; PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRIORITY JOURNAL; SURVIVAL RATE; SURVIVAL TIME; TREATMENT RESPONSE;

6-MERCAPTOPURINE; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DISEASE-FREE SURVIVAL; ETOPOSIDE; FEMALE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; PIPERAZINES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDNISONE; PYRIMIDINES; STEM CELL TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; VINCRISTINE; YOUNG ADULT;

EID: 84866308321     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2012.09240.x     Document Type: Article

References (12)

1. Chalandon, Y.T.X., Thomas, X., Hayette, S., Cayuela, J.M., Abbal, C., Escoffre-Barbe, M., Maury, S., Lepretre, S., Witz, F., Benboubker, L., Malfuson, J.V., Leguay, T., Buzyn, A., Lheritier, V., Bene, M.C., Lafage, M., Ifrah, N. & Dombret, H. (2008) First results of the GRAAPH-2005 study in younger adult patients with de novo Philadelphia positive acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts), 112, Abstract 12.
2. Fielding, A.K. (2010) How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 116, 3409-3417.
3. Foà, R., Vitale, A., Vignetti, M., Meloni, G., Guarini, A., De Propris, M.S., Elia, L., Paoloni, F., Fazi, P., Cimino, G., Nobile, F., Ferrara, F., Castagnola, C., Sica, S., Leoni, P., Zuffa, E., Fozza, C., Luppi, M., Candoni, A., Iacobucci, I., Soverini, S., Mandelli, F., Martinelli, G. & Baccarani, M. (2011) Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 118, 6521-6528.
4. Kebriaei, P., Saliba, R., Rondon, G., Chiattone, A., Luthra, R., Anderlini, P., Andersson, B., Shpall, E., Popat, U., Jones, R., Worth, L., Ravandi, F., Thomas, D., O'Brien, S., Kantarjian, H., de Lima, M., Giralt, S. & Champlin, R. (2012) Long-term follow-up of allogeneic hematopoietic stem cell transplantation for patients with philadelphia chromosome-positive acute lymphoblastic leukemia: impact of tyrosine kinase inhibitors on treatment outcomes. Biology of Blood and Marrow Transplantation, 18, 584-592.
5. Lee, H.J., Thompson, J.E., Wang, E.S. & Wetzler, M. (2011) Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives. Cancer, 117, 1583-1594.
6. Mizuta, S., Matsuo, K., Yagasaki, F., Yujiri, T., Hatta, Y., Kimura, Y., Ueda, Y., Kanamori, H., Usui, N., Akiyama, H., Miyazaki, Y., Ohtake, S., Atsuta, Y., Sakamaki, H., Kawa, K., Morishima, Y., Ohnishi, K., Naoe, T. & Ohno, R. (2011) Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia. Leukemia, 25, 41-47.
7. Moorman, A.V., Harrison, C.J., Buck, G.A., Richards, S.M., Secker-Walker, L.M., Martineau, M., Vance, G.H., Cherry, A.M., Higgins, R.R., Fielding, A.K., Foroni, L., Paietta, E., Tallman, M.S., Litzow, M.R., Wiernik, P.H., Rowe, J.M., Goldstone, A.H. & Dewald, G.W. (2007) Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood, 109, 3189-3197.
8. Nishiwaki, S., Miyamura, K., Kato, C., Terakura, S., Ohashi, K., Sakamaki, H., Nakao, S., Harigae, H. & Kodera, Y. (2010) Impact of post-transplant imatinib administration on Philadelphia chromosome-positive acute lymphoblastic leukaemia. Anticancer Research, 30, 2415-2418.
9. Pfeiffer, H., Wassmann, B., Bethge, W.A., Dengler, J., Bornhäuser, M., Stadler, M., Beelen, D., Günther, A., Vucinic, V., Burmeister, T., Stelljes, M., Schwerdtfeger, R., Schaefer-Eckhart, K., Bader, P., Kreyenberg, H., Schuld, P., Serve, H., Hoelzer, D., Goekbuget, N. & Ottmann, O.G. (2011) Updated long-term results of prophylactic and pre-emptive imatinib following allogeneic stem cell transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts), 118, 247.
10. Ram, R., Storb, R., Sandmaier, B.M., Maloney, D.G., Woolfrey, A., Flowers, M.E., Maris, M.B., Laport, G.G., Chauncey, T.R., Lange, T., Langston, A.A., Storer, B. & Georges, G.E. (2011) Nonmyeloablative conditioning with allogeneic hematopoietic cell transplantation for the treatment of high risk acute lymphoblastic leukemia. Haematologica, 96, 1113-1120.
11. Ribera, J.M., Oriol, A., González, M., Vidriales, B., Brunet, S., Esteve, J., Del Potro, E., Rivas, C., Moreno, M.J., Tormo, M., Martín-Reina, V., Sarrá, J., Parody, R., de Oteyza, J.P., Bureo, E. & Bernal, M.T. (2010) Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Haematologica, 95, 87-95.
12. Vignetti, M., Fazi, P., Cimino, G., Martinelli, G., Di Raimondo, F., Ferrara, F., Meloni, G., Ambrosetti, A., Quarta, G., Pagano, L., Rege-Cambrin, G., Elia, L., Bertieri, R., Annino, L., Foà, R., Baccarani, M. & Mandelli, F. (2007) Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosome-positive patients with acute lymphoblastic leukemia without additional chemotherapy: results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol. Blood, 109, 3676-3678.