Eliminating mother-to-child HIV transmission will require major improvements in maternal and child health services

Health Affairs

Volumn 31, Issue 7, 2012, Pages 1489-1497

  Barker, Pierre M ^a,b   Mate, Kedar ^c  

^a INSTITUTE FOR HEALTHCARE IMPROVEMENT   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; NEVIRAPINE; ZIDOVUDINE;

ANTIVIRAL THERAPY; ARTICLE; HEALTH CARE ACCESS; HEALTH CARE DELIVERY; HEALTH SERVICE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCOME; MAJOR CLINICAL STUDY; MATERNAL CARE; MATERNAL WELFARE; PREGNANCY; VERTICAL TRANSMISSION;

AFRICA SOUTH OF THE SAHARA; CHILD; CHILD HEALTH SERVICES; DELIVERY OF HEALTH CARE; FEMALE; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MATERNAL HEALTH SERVICES; MODELS, ORGANIZATIONAL; PREGNANCY; PROGRAM EVALUATION; QUALITY IMPROVEMENT;

EID: 84866298115     PISSN: 02782715     EISSN: 15445208     Source Type: Journal    
DOI: 10.1377/hlthaff.2012.0267     Document Type: Article

References (28)

1. World Health Organization, Joint United Nations Programme on HIV/AIDS, United Nations Children's Fund. Global HIV/AIDS response: epidemic update and health sector progress towards universal access. Progress report 2011. Geneva: WHO; 2011.
2. Mahy M, Stover J, Kiragu K, Hayashi C, Akwara P, Luo C, et al.What will it take to achieve virtual elimination of mother-to-child transmission of HIV? An assessment of current progress and future needs. Sex Transm Infect. 2010;86(Suppl 2): ii48-55.
3. Joint United Nations Programme on HIV/AIDS. Countdown to zero: global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive. Geneva: UNAIDS; 2011.
4. End Poverty 2015 Millennium Campaign. Overview: about the Millennium Development Goals [Internet]. New York (NY): United Nations; [cited 2012 Feb 21]. Available from: http://www.endpoverty 2015.org/goals
5. Thior I, Lockman S, Smeaton L, Shapiro R, Wester C, Heymann S, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA. 2006; 296(7):794-805.
6. Kilewo C, Karlsson K, Massawe A, Lyamuya E, Swai A, Mhalu F. Prevention of mother-to-child transmission of HIV-1 through breast-feeding by treating infants prophylactically with lamivudine in Dar es Salaam, Tanzania: the Mitra Study. J Acquir Immune Defic Syndr. 2008;48(3):315-23.
7. Newell M-L, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet. 2004;364:1236-43.
8. Ng'weshemi J, Urassa M, Isingo R, Mwaluko G, Ngalula J, Boerma T, et al. HIV impact on mother and child mortality in rural Tanzania. J Acquir Immune Defic Syndr. 2003; 33:393-404.
9. Friberg IK, Kinney MV, Lawn JE, Kerber KJ, Odubanjo MO, Bergh A-M, et al. Sub-Saharan Africa's mothers, newborns, and children: how many lives could be saved with targeted health interventions? PLoS Med. 2010;7(6):e1000295.
10. Rajaratnam J, Marcus J, Flaxman A, Wang H, Levin-Rector A. Neonatal, postneonatal, childhood, and under- mortality for 187 countries, 1970-2010: a systematic analysis of progress towards Millennium Development Goal 4. Lancet. 2010; 375(9730):1988-2008.
11. Bhutta Z, Chopra M, Axelson H, Berman P, Boerma T, Bryce J. Countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival. Lancet. 2010;375(9730):2032-44.
12. Bryce J, Gilroy K, Jones G, Hazel E, Black RE, Victora CG. The Accelerated Child Survival and Development programme in west Africa: a retrospective evaluation. Lancet. 2010; 375(9714):572-82.
13. Chopra M, Daviaud E, Pattinson R, Fonn S, Lawn J. Saving the lives of South Africa's mothers, babies, and children: can the health system deliver? Lancet. 2009;374:835-46.
14. Ndirangu J, Newell M-L, Thorne C, Bland R. Treating HIV-infected mothers reduces under 5 years of age mortality rates to levels seen in children of HIV-uninfected mothers in rural South Africa. Antivir Ther. 2012;17:81-90.
15. Paintsil E, Andiman W. Update on successes and challenges regarding mother-to-child transmission of HIV. Curr Opin Pediatr. 2009;21(1): 94-101.
16. World Health Organization. Rapid advice: use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. Geneva: WHO; 2009.
17. World Health Organization, United Nations Children's Fund. Countdown to 2015 decade report (2000- 2010) with country profiles: taking stock of maternal, newborn and child survival. Geneva: WHO; 2010.
18. Stringer E, Ekouevi D, Coetzee D, Tih P, Creek T, Stinson K. Coverage of nevirapine-based services to prevent mother-to-child HIV transmission in 4 African countries. JAMA. 2010;304(3):293-302.
19. To access the Appendix, click on the Appendix link in the box to the right of the article online
20. Horwood C, Vermaak K, Butler L, Haskings L, Phakathi S, Rollins N. Elimination of paediatric HIV in KwaZulu-Natal, South Africa: largescale assessment of interventions for the prevention of mother-to-child transmission. Bull World Health Organ. 2012;90:168-75.
21. UNAIDS Reference Group on Estimates, Modelling, and Projections. Working paper on mother-to-child HIV transmission rates for use in Spectrum [Internet]. Geneva: United Nations; 2011 6 Jun [cited 2012 Feb 21]. Available from: http://www .epidem.org/Publications/MTC Tratesworkingpaper.pdf
22. Barker PM, Mphatswe W, Rollins N. Antiretroviral drugs in the cupboard are not enough: the impact of health systems' performance on mother-tochild transmission of HIV. J Acquir Immune Defic Syndr. 2011;56(2): e45-8.
23. World Health Organization. Guidelines on HIV and infant feeding 2010: principles and recommendations for infant feeding in the context of HIV and a summary of evidence. Geneva: WHO; 2010.
24. Goga A, Dinh T, Jackson D. Results of an evaluation of effectiveness of the national PMTCT programme at six weeks postpartum, SA. Paper presented at: Fifth South African AIDS Conference; Durban, South Africa; 2011.
25. Joint United Nations Programme on HIV/AIDS. Botswana [Internet]. Geneva: UNAIDS; 2010 [cited 2012 Mar 6]. Available from: http://www.unaids.org/en/Region scountries/Countries/Botswana/
26. Stover J, Fidzani B, Molomo BC, Moeti T, Musuka G. Estimated HIV trends and program effects in Botswana. PLoS ONE. 2008;3(11): e3729.
27. Rollins N, Little K, Mzolo S, Horwood C, Newell ML. Surveillance of mother-to-child transmission prevention programmes at immunization clinics: the case for universal screening. AIDS. 2007;21(10): 1341-7.
28. Cameron D, Gerber A, Mbatha M, Mutyabule J, Swart H. Nurseinitiation and maintenance of patients on antiretroviral therapy: are nurses in primary care clinics initiating ART after attending NIMART training? S Afr Med Journal. 2012; 102(2):98-100.