Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Suidan, Georgette L ^a,b   Dickerson, Jonathan W ^a,b   Johnson, Holly L ^d   Chan, Theresa W ^a   Pavelko, Kevin D ^d   Pirko, Istvan ^b,c   Seroogy, Kim B ^a,b   Johnson, Aaron J ^a,d  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Blood brain barrier (BBB); CD8 T cell; CNS vascular permeability; Fetal liver kinase 1 (flk 1); FMS related tyrosine kinase 1 (flt 1); Neuropilin 1 (NRP 1); Vascular endothelial growth factor (VEGF)

Indexed keywords

MESSENGER RNA; NEUROPILIN 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; BRAIN INFECTION; CD8+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; GENE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 GENE; VIRUS INFECTION;

EID: 84866274602     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-218     Document Type: Article

References (19)

1. Weiss N, Miller F, Cazaubon S, Couraud PO. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta 2009, 1788:842-857. 10.1016/j.bbamem.2008.10.022, 19061857.
2. Kabakus N, Gurgoze MK, Yildirim H, Godekmerdan A, Aydin M. Acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage associated with herpes simplex virus type I. J Trop Pediatr 2005, 51:245-249. 10.1093/tropej/fmh109, 15917264.
3. Brown H, Hien TT, Day N, Mai NT, Chuong LV, Chau TT, Loc PP, Phu NH, Bethell D, Farrar J, Gatter K, White N, Turner G. Evidence of blood-brain barrier dysfunction in human cerebral malaria. Neuropathol Appl Neurobiol 1999, 25:331-340. 10.1046/j.1365-2990.1999.00188.x, 10476050.
4. Suidan GL, Pirko I, Johnson AJ. A potential role for CD8+ T-cells as regulators of CNS vascular permeability. Neurol Res 2006, 28:250-255. 10.1179/016164106X98116, 16687049.
5. Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999, 274:23463-23467. 10.1074/jbc.274.33.23463, 10438525.
6. Deininger MH, Winkler S, Kremsner PG, Meyermann R, Schluesener HJ. Angiogenic proteins in brains of patients who died with cerebral malaria. J Neuroimmunol 2003, 142:101-111. 10.1016/S0165-5728(03)00250-9, 14512169.
7. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA, Rothman AL. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever. J Virol 2007, 81:1592-1600. 10.1128/JVI.01642-06, 1797579, 17151115.
8. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006, 7:359-371. 10.1038/nrm1911, 16633338.
9. Soker S, Miao HQ, Nomi M, Takashima S, Klagsbrun M. VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding. J Cell Biochem 2002, 85:357-368. 10.1002/jcb.10140, 11948691.
10. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998, 92:735-745. 10.1016/S0092-8674(00)81402-6, 9529250.
11. Starzec A, Vassy R, Martin A, Lecouvey M, Di Benedetto M, Crepin M, Perret GY. Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1. Life Sci 2006, 79:2370-2381. 10.1016/j.lfs.2006.08.005, 16959272.
12. Johnson AJ, Mendez-Fernandez Y, Moyer AM, Sloma CR, Pirko I, Block MS, Rodriguez M, Pease LR. Antigen-specific CD8+ T cells mediate a peptide-induced fatal syndrome. J Immunol 2005, 174:6854-6862.
13. Johnson HL, Chen Y, Suidan GL, McDole JR, Lohrey AK, Hanson LM, Jin F, Pirko I, Johnson AJ. A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption. Journal of neuroinflammation 2012, 9:60. 10.1186/1742-2094-9-60, 3350446, 22452799.
14. Pirko I, Suidan GL, Rodriguez M, Johnson AJ. Acute hemorrhagic demyelination in a murine model of multiple sclerosis. Journal of neuroinflammation 2008, 5:31. 10.1186/1742-2094-5-31, 2474604, 18606015.
15. Suidan GL, McDole JR, Chen Y, Pirko I, Johnson AJ. Induction of blood brain barrier tight junction protein alterations by CD8 T cells. PLoS One 2008, 3:e3037. 10.1371/journal.pone.0003037, 2516328, 18725947.
16. Suidan GL, Dickerson JW, Chen Y, McDole JR, Tripathi P, Pirko I, Seroogy KB, Johnson AJ. CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions. J Immunol 2010, 184:1031-1040. 10.4049/jimmunol.0902773, 2896014, 20008293.
17. Hemmerle AM, Dickerson JW, Herring NR, Schaefer TL, Vorhees CV, Williams MT, Seroogy KB. (+/-)3,4-methylenedioxymethamphetamine (" Ecstasy" ) treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. J Comp Neurol 2012, 520:2459-2474. 10.1002/cne.23048, 22237931.
18. Detmar M, Velasco P, Richard L, Claffey KP, Streit M, Riccardi L, Skobe M, Brown LF. Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas. Am J Pathol 2000, 156:159-167. 10.1016/S0002-9440(10)64715-3, 1868649, 10623663.
19. Seroogy KB, Herman JP. In situ hybridization approaches to the study of the nervous system. Neurochemistry: A Practical Approach 1997, 121-150. Oxford: Oxford University Press, Turner AJ, Bachelard HS, 2.