ErbB3 mRNA leukocyte levels as a biomarker for major depressive disorder

BMC Psychiatry

Volumn 12, Issue , 2012, Pages

  Milanesi, Elena ^a   Minelli, Alessandra ^a   Cattane, Nadia ^a   Cattaneo, Annamaria ^a   Mora, Cristina ^a   Barbon, Alessandro ^a   Mallei, Alessandra ^b   Popoli, Maurizio ^b   Florio, Vincenzo ^c   Conca, Andreas ^c   Bignotti, Stefano ^d   Gennarelli, Massimo ^a,d  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CENTRAL HOSPITAL OF BOLZANO   (Italy)

^d IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

Author keywords

Biomarkers; ErbB3; Fgfr1; Leukocytes; Major Depressive Disorder MDD

Indexed keywords

ANTIDEPRESSANT AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ESCITALOPRAM; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MESSENGER RNA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SEROTONIN UPTAKE INHIBITOR; BIOLOGICAL MARKER; GROWTH FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DSM-IV; EDUCATIONAL STATUS; FEMALE; FRONTAL CORTEX; FRONTAL LOBE; HIPPOCAMPUS; HUMAN; LEUKOCYTE; MAJOR DEPRESSION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PSYCHOPHARMACOTHERAPY; RAT; REAL TIME POLYMERASE CHAIN REACTION; AGED; BIPOLAR DISORDER; CLINICAL ARTICLE; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; FOOTSHOCK; GENE EXPRESSION; GENETIC ANALYSIS; HOUSEKEEPING GENE; MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; TREATMENT DURATION;

ADULT; ANIMALS; ANTIDEPRESSIVE AGENTS; BIOLOGICAL MARKERS; COHORT STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ERBB-3; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, MESSENGER;

EID: 84866273311     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-12-145     Document Type: Article

References (17)

1. Belmaker RH, Agam G. Major depressive disorder. N Engl J Med 2008, 358(1):55-68. 10.1056/NEJMra073096, 18172175.
2. Levinson DF. The genetics of depression: a review. Biol Psychiatry 2006, 60(2):84-92. 10.1016/j.biopsych.2005.08.024, 16300747.
3. Lesko LJ, Atkinson AJ. Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies. Annu Rev Pharmacol Toxicol 2001, 41:347-366. 10.1146/annurev.pharmtox.41.1.347, 11264461.
4. Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011, 36(12):2375-2394. 10.1038/npp.2011.151, 21814182.
5. Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen MG, Placentino A, Giovannini C, Rillosi L, Ventriglia M, Riva MA, et al. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 2010, 11(6):763-773. 10.3109/15622971003611319, 20334574.
6. Bocchio-Chiavetto L, Zanardini R, Bortolomasi M, Abate M, Segala M, Giacopuzzi M, Riva MA, Marchina E, Pasqualetti P, Perez J, et al. Electroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patients. Eur Neuropsychopharmacol 2006, 16(8):620-624. 10.1016/j.euroneuro.2006.04.010, 16757154.
7. Minelli A, Zanardini R, Abate M, Bortolomasi M, Gennarelli M, Bocchio-Chiavetto L. Vascular Endothelial Growth Factor (VEGF) serum concentration during electroconvulsive therapy (ECT) in treatment resistant depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35(5):1322-1325. 10.1016/j.pnpbp.2011.04.013, 21570438.
8. Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger JI, Niculescu AB. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry 2009, 14(2):156-174. 10.1038/mp.2008.11, 18301394.
9. Gaughran F, Payne J, Sedgwick PM, Cotter D, Berry M. Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Brain Res Bull 2006, 70(3):221-227. 10.1016/j.brainresbull.2006.04.008, 16861106.
10. Aston C, Jiang L, Sokolov BP. Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry 2005, 10(3):309-322. 10.1038/sj.mp.4001565, 15303102.
11. Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T. Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neurosci Res 2008, 60(2):184-191. 10.1016/j.neures.2007.10.010, 18068248.
12. Sibilia M, Kroismayr R, Lichtenberger BM, Natarajan A, Hecking M, Holcmann M. The epidermal growth factor receptor: from development to tumorigenesis. Differentiation 2007, 75(9):770-787. 10.1111/j.1432-0436.2007.00238.x, 17999740.
13. Lemke G. Neuregulin-1 and myelination. Sci STKE 2006, 2006(325):pe11. 10.1126/stke.3252006pe11, 16522871.
14. Riethmacher D, Sonnenberg-Riethmacher E, Brinkmann V, Yamaai T, Lewin GR, Birchmeier C. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 1997, 389(6652):725-730. 10.1038/39593, 9338783.
15. Borroto-Escuela DO, Romero-Fernandez W, Mudo G, Perez-Alea M, Ciruela F, Tarakanov AO, Narvaez M, Di Liberto V, Agnati LF, Belluardo N, et al. Fibroblast growth factor receptor 1-5-Hydroxytryptamine 1A Heteroreceptor complexes and their enhancement of hippocampal plasticity. Biol Psychiatry 2012, 71(1):84-91. 10.1016/j.biopsych.2011.09.012, 22035699.
16. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998, 59(Suppl 20):22-33. quiz 34-57.
17. Musazzi L, Milanese M, Farisello P, Zappettini S, Tardito D, Barbiero VS, Bonifacino T, Mallei A, Baldelli P, Racagni G, et al. Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS One 2010, 5(1):e8566. 10.1371/journal.pone.0008566, 2797327, 20052403.