-
1
-
-
66149164593
-
Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
-
Teachey DT, Grupp SA, Brown VI. Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies Brit J Haematol 2009; 145:569-580.
-
(2009)
Brit J Haematol
, vol.145
, pp. 569-580
-
-
Teachey, D.T.1
Grupp, S.A.2
Brown, V.I.3
-
2
-
-
1242307298
-
Prognosis in childhood and adult acute lymphoblastic leukaemia: a question of maturation?
-
Plasschaert SL, Kamps WA, Vellenga E, de Vries EG, de Bont ES. Prognosis in childhood and adult acute lymphoblastic leukaemia: a question of maturation? Cancer Treat Rev 2004; 30: 37-51.
-
(2004)
Cancer Treat Rev
, vol.30
, pp. 37-51
-
-
Plasschaert, S.L.1
Kamps, W.A.2
Vellenga, E.3
de Vries, E.G.4
de Bont, E.S.5
-
3
-
-
0035093711
-
Philadelphia chromosome-positive acute lymphocytic leukemia
-
Radich JP. Philadelphia chromosome-positive acute lymphocytic leukemia. Hematol Onocol Clin N 2001; 15: 21-36.
-
(2001)
Hematol Onocol Clin N
, vol.15
, pp. 21-36
-
-
Radich, J.P.1
-
4
-
-
0034141934
-
A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia
-
Cobaleda C, Gutiérrez-Cianca N, Pérez-Losada J, et al. A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia. Blood 2000; 95: 1007-1013.
-
(2000)
Blood
, vol.95
, pp. 1007-1013
-
-
Cobaleda, C.1
Gutiérrez-Cianca, N.2
Pérez-Losada, J.3
-
5
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
6
-
-
77951643083
-
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway
-
Kuo HP, Lee DF, Chen CT, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science 2010; 3: 1-12.
-
(2010)
Science
, vol.3
, pp. 1-12
-
-
Kuo, H.P.1
Lee, D.F.2
Chen, C.T.3
-
7
-
-
77954235821
-
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
-
Sparks CA, Guertin DA. Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene 2010; 29: 3733-3744.
-
(2010)
Oncogene
, vol.29
, pp. 3733-3744
-
-
Sparks, C.A.1
Guertin, D.A.2
-
8
-
-
0345166113
-
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
-
Brown VI, Fang J, Alcorn K, et al. Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proc Natl Acad Sci USA 2003; 100: 15113-15118.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15113-15118
-
-
Brown, V.I.1
Fang, J.2
Alcorn, K.3
-
9
-
-
23744494993
-
Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
-
Avellino R, Romano S, Parasole R, et al. Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood 2005; 106: 1400-1406.
-
(2005)
Blood
, vol.106
, pp. 1400-1406
-
-
Avellino, R.1
Romano, S.2
Parasole, R.3
-
10
-
-
51349108718
-
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+leukemia cells
-
Kharas MG, Janes MR, Scarfone VM, et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+leukemia cells. J Clin Invest 2008; 118: 3038-3050.
-
(2008)
J Clin Invest
, vol.118
, pp. 3038-3050
-
-
Kharas, M.G.1
Janes, M.R.2
Scarfone, V.M.3
-
11
-
-
58549116685
-
Hypersensitivity of Ph-positive lymphoid cell lines to rapamycin: possible clinical application of mTOR inhibitor
-
Hirase C, Maeda Y, Takai S, et al. Hypersensitivity of Ph-positive lymphoid cell lines to rapamycin: possible clinical application of mTOR inhibitor. Leukemia Res 2009; 33: 450-459.
-
(2009)
Leukemia Res
, vol.33
, pp. 450-459
-
-
Hirase, C.1
Maeda, Y.2
Takai, S.3
-
12
-
-
61849157793
-
Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease
-
Brown VI, Seif AE, Reid GS, Teachey DT, Grupp SA. Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease Immunol Res 2008; 42:84-105.
-
(2008)
Immunol Res
, vol.42
, pp. 84-105
-
-
Brown, V.I.1
Seif, A.E.2
Reid, G.S.3
Teachey, D.T.4
Grupp, S.A.5
-
13
-
-
84861332196
-
The calculation of ld50 in new drugs with software SPSS
-
Zhou YP. The calculation of ld50 in new drugs with software SPSS. Prog Pharm Sci 2003; 27: 314-316.
-
(2003)
Prog Pharm Sci
, vol.27
, pp. 314-316
-
-
Zhou, Y.P.1
-
14
-
-
43049101649
-
Two hour exposure to sodium butyrate sensitizes bladder cancer to anticancer drugs
-
Wang DG, Wang ZP, Tian BQ, Li X, Li S, Tian Y. Two hour exposure to sodium butyrate sensitizes bladder cancer to anticancer drugs. Int J Urol 2008; 15: 435-441.
-
(2008)
Int J Urol
, vol.15
, pp. 435-441
-
-
Wang, D.G.1
Wang, Z.P.2
Tian, B.Q.3
Li, X.4
Li, S.5
Tian, Y.6
-
15
-
-
76349104427
-
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
-
Janes MR, Limon JJ, So L, et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 2010; 16: 205-213.
-
(2010)
Nat Med
, vol.16
, pp. 205-213
-
-
Janes, M.R.1
Limon, J.J.2
So, L.3
-
16
-
-
42449146501
-
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
-
McCubrey JA, Steelman LS, Abrams SL, et al. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 2008; 22: 708-722.
-
(2008)
Leukemia
, vol.22
, pp. 708-722
-
-
McCubrey, J.A.1
Steelman, L.S.2
Abrams, S.L.3
-
17
-
-
34147146014
-
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
-
Zeng Z, Sarbassov D, Samudio IJ, et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 2007; 109: 3509-3512.
-
(2007)
Blood
, vol.109
, pp. 3509-3512
-
-
Zeng, Z.1
Sarbassov, D.2
Samudio, I.J.3
-
18
-
-
20844448882
-
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species
-
Kim JH, Chu SC, Gramlich JL, et al. Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood 2005; 105: 1717-1723.
-
(2005)
Blood
, vol.105
, pp. 1717-1723
-
-
Kim, J.H.1
Chu, S.C.2
Gramlich, J.L.3
-
19
-
-
46149092748
-
Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
-
Jiang BH, Liu LZ. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Update 2008; 11: 63-76.
-
(2008)
Drug Resist Update
, vol.11
, pp. 63-76
-
-
Jiang, B.H.1
Liu, L.Z.2
-
20
-
-
34548188741
-
Self-eating and self-killing: crosstalk between autophagy and apoptosis
-
Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nature 2007; 8: 741-752.
-
(2007)
Nature
, vol.8
, pp. 741-752
-
-
Maiuri, M.C.1
Zalckvar, E.2
Kimchi, A.3
Kroemer, G.4
-
21
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
23
-
-
67650252764
-
RAD001 (everolimus) induces autophagy in acute lymphoblastic leukemia
-
Crazzolara R, Bradstock KF, Bendall LJ. RAD001 (everolimus) induces autophagy in acute lymphoblastic leukemia. Autophagy 2009; 5: 727-728.
-
(2009)
Autophagy
, vol.5
, pp. 727-728
-
-
Crazzolara, R.1
Bradstock, K.F.2
Bendall, L.J.3
-
24
-
-
70349322878
-
Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine
-
Janusa A, Linkea A, Cebula B, Robak T, Smolewski P. Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine. Anti-Cancer Drug 2009; 20: 693-701.
-
(2009)
Anti-Cancer Drug
, vol.20
, pp. 693-701
-
-
Janusa, A.1
Linkea, A.2
Cebula, B.3
Robak, T.4
Smolewski, P.5
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