Suspension cultures of bone-marrow-derived mesenchymal stem cells: Effects of donor age and glucose level

Stem Cells and Development

Volumn 21, Issue 14, 2012, Pages 2718-2723

  Stolzing, Alexandra ^a   Bauer, Eva ^a   Scutt, Andrew ^b  

^a FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

AGING; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL COUNT; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL RENEWAL; COLONY FORMATION; COLONY FORMING CELL; FIBROBLAST; IN VITRO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUSPENSION CELL CULTURE;

AGE FACTORS; ANIMALS; BONE MARROW; CELL AGING; CELL COUNT; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CULTURE MEDIA; FEMALE; GLUCOSE; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STROMAL CELLS; RATS; RATS, WISTAR; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 84866262465     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2011.0406     Document Type: Article

References (29)

1. Shih HN, LY Shih, TH Sung and YC Chang. (2005). Restoration of bone defect and enhancement of bone ingrowth using partially demineralized bone matrix and marrow stromal cells. J Orthop Res 23:1293-1299.
2. Bieback K, S Kern, H Kluter and H Eichler. (2004). Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells 22:625-634. (Pubitemid 39014578)
3. Vaananen HK. (2005). Mesenchymal stem cells. Ann Med 37:469-479. (Pubitemid 41693577)
4. Hutson EL, S Boyer and PG Genever. (2005). Rapid isolation, expansion, and differentiation of osteoprogenitors from fullterm umbilical cord blood. Tissue Eng 11:1407-1420. (Pubitemid 41636427)
5. Kadivar M, S Khatami, Y Mortazavi, MA Shokrgozar, M Taghikhani and M Soleimani. (2006). In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells. Biochem Biophys Res Commun 340:639-647. (Pubitemid 43021794)
6. Zhao P, H Ise, M Hongo, M Ota, I Konishi and T Nikaido. (2005). Human amniotic mesenchymal cells have some characteristics of cardiomyocytes. Transplantation 79:528-535. (Pubitemid 40365880)
7. Hong SH, EJ Gang, JA Jeong, C Ahn, SH Hwang, IH Yang, HK Park, H Han and H Kim. (2005). In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 330:1153-1161.
8. Le Blanc K. (2003). Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 5:485-489. (Pubitemid 38028708)
9. Friedenstein AJ, KV Petrakova, AI Kurolesova and GP Frolova. (1968). Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6:230-247.
10. Dominici M, K Le Blanc, I Mueller, I Slaper-Cortenbach, F Marini, D Krause, R Deans, A Keating, D Prockop and E Horwitz. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317. (Pubitemid 44269669)
11. Kaiser S, B Hackanson, M Follo, A Mehlhorn, K Geiger, G Ihorst and U Kapp. (2007). BM cells giving rise to MSC in culture have a heterogeneous CD34 and CD45 phenotype. Cytotherapy 9:439-450. (Pubitemid 47386681)
12. Rauseo A, A Pacilli, A Palena and SA De Cosmo. (2010). Management of type 2 diabetes in geriatric patients. J Nephrol 23 Suppl 15:S72-S79.
13. Stolzing A, D Sellers, O Llewelyn and A Scutt. (2010). Diabetes induced changes in rat mesenchymal stem cells. Cells Tissues Organs 191:453-465.
14. Fricke S, M Ackermann, A Stolzing, C Schimmelpfennig, N Hilger, J Jahns, G Hildebrandt, F Emmrich, P Ruschpler, et al. (2009). Allogeneic non-adherent bone marrow cells facilitate hematopoietic recovery but do not lead to allogeneic engraftment. PLoS One 4:e6157.
15. Zhang ZL, J Tong, RN Lu, AM Scutt, D Goltzman and DS Miao. (2009). Therapeutic potential of non-adherent BMderived mesenchymal stem cells in tissue regeneration. Bone Marrow Transplant 43:69-81.
16. Stolzing A, N Coleman and A Scutt. (2006). Glucose-induced replicative senescence in mesenchymal stem cells. Rejuvenation Res 9:31-35.
17. Cramer C, E Freisinger, RK Jones, DP Slakey, CL Dupin, ER Newsome, EU Alt and R Izadpanah. (2010). Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells. Stem Cells Dev 19:1875-1884.
18. Scutt A and P Bertram. (1995). Bone marrow cells are targets for the anabolic actions of prostaglandin E2 on bone: induction of a transition from nonadherent to adherent osteoblast precursors. J Bone Miner Res 10:474-487.
19. Dobson KR, L Reading, M Haberey, X Marine and A Scutt. (1999). Centrifugal isolation of bone marrow from bone: an improved method for the recovery and quantitation of bone marrow osteoprogenitor cells from rat tibiae and femurae. Calcif Tissue Int 65:411-413. (Pubitemid 29514082)
20. Stolzing A and A Scutt. (2006). Age-related impairment of mesenchymal progenitor cell function. Aging Cell 5:213-224. (Pubitemid 43809939)
21. Sotiropoulou PA, SA Perez, M Salagianni, CN Baxevanis and M Papamichail. (2006). Cell culture medium composition and translational adult bone marrow-derived stem cell research. Stem Cells 24:1409-1410. (Pubitemid 44464710)
22. Sugimoto R, M Enjoji, M Kohjima, S Tsuruta, M Fukushima, M Iwao, T Sonta, K Kotoh, T Inoguchi and M Nakamuta. (2005). High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase. Liver Int 25:1018-1026. (Pubitemid 41404025)
23. Ryu JM, MY Lee, SP Yun and HJ Han. (2010). High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-beta1 expression via Ca2 +/PKC/MAPKs and PI3K/Akt/mTOR signal pathways. J Cell Physiol 224:59-70.
24. Weil BR, AM Abarbanell, JL Herrmann, Y Wang and DR Meldrum. (2009). High glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell growth factor production or proliferation. Am J Physiol Regul Integr Comp Physiol 296:R1735-R1743.
25. Stolzing A, E Jones, D McGonagle and A Scutt. (2008). Agerelated changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev 129:163-173.
26. Sethe S, A Scutt and A Stolzing. (2006). Aging of mesenchymal stem cells. Ageing Res Rev 5:91-116. (Pubitemid 43139669)
27. Fricke S, C Fricke, C Oelkrug, N Hilger, U Schonfelder, M Kamprad, J Lehmann, J Boltze, F Emmrich and U Sack. (2010). Characterization of murine non-adherent bone marrow cells leading to recovery of endogenous hematopoiesis. Cell Mol Life Sci 67:4095-4106.
28. Ratajczak MZ, DM Shin, J Ratajczak, M Kucia and A Bartke. (2011). A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner? Aging (Albany NY) 2:875-883.
29. Ratajczak J, E Zuba-Surma, E Paczkowska, M Kucia, P Nowacki and MZ Ratajczak. (2011). Stem cells for neural regeneration-apotential application of verysmall embryoniclike stem cells. J Phys Pharmacol 62:3-11.