Determination of amlodipine in human plasma using automated online solid-phase extraction HPLC-tandem mass spectrometry: Application to a bioequivalence study of Chinese volunteers

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 614-618

  Shentu, Jianzhong ^a   Fu, Lizhi ^a   Zhou, Huili ^a   Hu, Xing Jiang ^a   Liu, Jian ^a   Chen, Junchun ^a   Wu, Guolan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Amlodipine; Human plasma; Mass spectrometry; Online solid phase extraction

Indexed keywords

AMLODIPINE; FLUOXETINE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; AUTOMATION; BIOEQUIVALENCE; CHINESE; CONCENTRATION (PARAMETERS); DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; PURIFICATION; QUALITY CONTROL; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; AMLODIPINE; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOMATION, LABORATORY; CALCIUM CHANNEL BLOCKERS; CALIBRATION; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DRUG STABILITY; HUMANS; LIMIT OF DETECTION; LINEAR MODELS; ONLINE SYSTEMS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY;

EID: 84866243008     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.06.014     Document Type: Article

References (9)

1. Murdoch D., Heel R.C. Amlodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease. Drugs 1991, 41:478-505.
2. Tatar S., Atmaca S. Determination of amlodipine in human plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B: Biomed. Sci. Appl. 2001, 758:305-310.
3. Zhang Z., Wang D., Zhang L., Du M., Chen G. Determination of diuretics in human urine by hollow fiber-based liquid-liquid-liquid microextraction coupled to high performance liquid chromatography. Analyst 2008, 133:1187-1194.
4. Monkman S.C., Ellis J.S., Cholerton S., Thomason J.M., Seymour R.A., Idle J.R. Automated gas chromatographic assay for amlodipine in plasma and gingival crevicular fluid. J. Chromatogr. B: Biomed. Appl. 1996, 678:360-364.
5. Zou Q., Zhan Y., Ge Z., Wei P., Ouyang P. Liquid chromatography-mass spectrometry method for the determination of amlodipine in human plasma and its application in a bioequivalence study. Arzneimittelforschung 2009, 59:383-391.
6. Ramani A.V., Sengupta P., Mullangi R. Development and validation of a highly sensitive and robust LC-ESI-MS/MS method for simultaneous quantitation of simvastatin acid, amlodipine and valsartan in human plasma: application to a clinical pharmacokinetic study. Biomed. Chromatogr. 2009, 23:615-622.
7. Pilli N.R., Inamadugu J.K., Mullangi R., Karra V.K., Vaidya J.R., Rao J.V. Simultaneous determination of atorvastatin, amlodipine, ramipril and benazepril in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomed. Chromatogr. 2011, 25:439-449.
8. Bhatt J., Singh S., Subbaiah G., Shah B., Kambli S., Ameta S. A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the estimation of amlodipine in human plasma. Biomed. Chromatogr. 2007, 21:169-175.
9. Wei X., Yang G., Qi L., Chen Y. Determination of nicardipine and amlodipine in human plasma using on-line solid-phase extraction with a monolithic weak cation-exchange column. Talanta 2009, 77:1197-1202.