The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy

Biomaterials

Volumn 33, Issue 33, 2012, Pages 8657-8669

  Xiao, Haihua ^a,b   Song, Haiqin ^c   Zhang, Yu ^d   Qi, Ruogu ^a,b   Wang, Rui ^a,b   Xie, Zhigang ^a   Huang, Yubin ^a   Li, Yuxin ^d   Wu, Yin ^d   Jing, Xiabin ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^d NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

Amphiphilic copolymer; Drug delivery systems; Micelles; Multinuclear platinum drugs

Indexed keywords

AMPHIPHILIC COPOLYMERS; AMPHIPHILICS; ANTI-TUMOR EFFICACY; BIODEGRADABLE BLOCK COPOLYMERS; BLOOD CIRCULATION; CIS-PLATIN; DINUCLEAR; DRUG DELIVERY SYSTEM; NANOMICELLES; OXALIPLATIN; PLATINUM DRUGS; PRODRUGS; SELF-ASSEMBLE;

BLOCK COPOLYMERS; CARDIOVASCULAR SYSTEM; DRUG DELIVERY; MICELLES; PLATINUM COMPOUNDS; POLYMERS; TOXICITY;

PLATINUM;

CISPLATIN; COPOLYMER; DINUCLEAR PLATINUM; OXALIPLATIN; PLATINUM; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CIRCULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; HUMAN; HUMAN CELL; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE, TUMOR; CISPLATIN; HUMANS; MICE; MICROSCOPY, CONFOCAL; NANOSTRUCTURES; ORGANOPLATINUM COMPOUNDS; PLATINUM; POLYMERS; PRODRUGS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84866184407     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.08.015     Document Type: Article

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