Is the pain of topical photodynamic therapy with methyl aminolevulinate any different from that with 5-aminolaevulinic acid?

Photodermatology Photoimmunology and Photomedicine

Volumn 28, Issue 5, 2012, Pages 272-273

  Ibbotson, Sally H ^a   Valentine, Ronan ^a   Hearn, Ross ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

5 aminolaevulinic acid (ALA); Methyl aminolevulinate (MAL); Pain; Photodynamic therapy (PDT)

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID METHYL ESTER; PORPHIN; UNCLASSIFIED DRUG;

ARTICLE; BASAL CELL CARCINOMA; BOWEN DISEASE; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; PAIN; PAIN ASSESSMENT; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; TREATMENT DURATION; VISUAL ANALOG SCALE;

ADMINISTRATION, TOPICAL; AMINOLEVULINIC ACID; BOWEN'S DISEASE; CARCINOMA, BASAL CELL; HUMANS; MALE; PAIN; PAIN MEASUREMENT; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SKIN NEOPLASMS;

EID: 84866175843     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2012.00684.x     Document Type: Article

References (5)

1. Wiegell SR, Stender IM, Na R, Wulf HC. Pain associated with photodynamic therapy using 5-aminolevulinic acid or 5-aminolevulinic acid methylester on tape-stripped normal skin. Arch Dermatol 2003; 139: 1173-1177.
2. Moloney FJ, Collins P. Randomized, double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis. Br J Dermatol 2007; 157: 87-91.
3. Attili SK, Sasi K, Dawe R, Ibbotson SH. A review of pain experienced during topical photodynamic therapy - our experience in Dundee. Photodiagnosis Photodyn Ther 2011; 8: 53-57.
4. Valentine RM, Ibbotson SH, Brown TA, Wood K, Moseley H. A quantitative comparison of 5-aminolaevulinic acid and methyl aminolevulinate-induced fluorescence, photobleaching and pain during photodynamic therapy. Photochem Photobiol 2011; 87: 242-249.
5. Morton CA, McKenna KE, Rhodes LE. Guidelines for topical photodynamic therapy: update. Br J Dermatol 2008; 159: 1245-1266.