Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging

Journal of Nuclear Medicine

Volumn 53, Issue 9, 2012, Pages 1462-1470

  Lee, Young Kyoung ^a   Jeong, Jae Min ^a   Hoigebazar, Lathika ^a   Yang, Bo Yeun ^a   Lee, Yun Sang ^a   Lee, Byung Chul ^a   Youn, Hyewon ^a,b   Lee, Dong Soo ^a,c   Chung, June Key ^a   Lee, Myung Chul ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Amphiphile; Lactose; Mannose; Nanocrystal; Q dot; RGD; Tween 60

Indexed keywords

ARGININE; ASPARTIC ACID; GALLIUM 68; GLYCINE; LACTOSE; LIGAND; MACROGOL; MACROGOL DERIVATIVE; MANNOSE; NANOPARTICLE; POLYSORBATE 60;

ARTICLE; BINDING ASSAY; DIAGNOSTIC IMAGING; ENCAPSULATION; EX VIVO STUDY; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEAR MEDICINE; PH; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REACTION TIME; REPRODUCIBILITY; TEMPERATURE;

ANIMALS; CAPSULES; CELL LINE, TUMOR; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTOSE; LIGANDS; LIVER; MANNOSE; MICE; MOLECULAR IMAGING; NANOPARTICLES; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; POLYSORBATES; QUANTUM DOTS; SPLEEN;

EID: 84866174451     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.092759     Document Type: Article

References (38)

1. Susumu K, Mei BC, Mattoussi H. Multifunctional ligands based on dihydrolipoic acid and polyethylene glycol to promote biocompatibility of quantum dots. Nat Protoc. 2009;4:424-436.
2. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003;17:545-580.
3. Pathak P, Katiyar VK. Multi-functional nanoparticles and their role in cancer drug delivery: a review. J Nanotechnol Online. 2007. Available at: http://www.azonano.com/article.aspx?ArticleID=1903. Accessed July 30, 2012.
4. Akerman ME, Chan WC, Laakkonen P, Bhatia SN, Ruoslahti E. Nanocrystal targeting in vivo. Proc Natl Acad Sci USA. 2002;99:12617-12621.
5. Gruner SM.Materials. In: OstroMJ, ed. Properties of Liposomal Bilayers in Liposomes from Biophysics to Therapeutics. New York, NY: Marcel Dekker; 1987:1-38.
6. Cressman S, Dobson I, Lee JB, Tam YY, Cullis PR. Synthesis of a labeled RGD-lipid, its incorporation into liposomal nanoparticles, and their trafficking in cultured endothelial cells. Bioconjug Chem. 2009;20:1404-1411.
7. Leatherdale CA, Woo WK, Mikulec FV, Bawendi MG. On the absorption cross section of CdSe nanocrystal quantum dots. J Phys Chem B. 2002;106:7619-7622.
8. Carion O, Mahler B, Pons T, Dubertret B. Synthesis, encapsulation, purification and coupling of single quantum dots in phospholipid micelles for their use in cellular and in vivo imaging. Nat Protoc. 2007;2:2383-2390.
9. Dixit SK, Goicochea NL, Daniel MC, et al. Quantum dot encapsulation in viral capsids. Nano Lett. 2006;6:1993-1999.
10. Reiss P, Protiere M, Li L. Core/Shell semiconductor nanocrystals. Small. 2009;5:154-168.
11. Murray CB, Norris DJ, Bawendi MG. Synthesis and characterization of nearly monodisperse Cde (E = S, Se, Te) semiconductor nanocrystallites. J Am Chem Soc. 1993;115:8706-8715.
12. Uyeda HT, Medintz IL, Jaiswal JK, Simon SM, Mattoussi H. Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. J Am Chem Soc. 2005;127:3870-3878.
13. Dubois F, Mahler B, Dubertret B, Doris E, Mioskowski C. Aversatile strategy for quantum dot ligand exchange. J Am Chem Soc. 2007;129:482-483.
14. Gerion D, Pinaud F, Williams SC, et al. Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots. J Phys Chem B. 2001;105:8861-8871.
15. Yu WW, Chang E, Falkner JC, et al. Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers. J Am Chem Soc. 2007;129:2871-2879.
16. Fernandez-Argüelles MT, Yakovlev A, Sperling RA, et al. Synthesis and characterization of polymer-coated quantum dots with integrated acceptor dyes as FRET-based nanoprobes. Nano Lett. 2007;7:2613-2617.
17. Wang CH, Hsu YS, Peng CA. Quantum dots encapsulated with amphiphilic alginate as bioprobe for fast screening anti-dengue virus agents. Biosens Bioelectron. 2008;24:1018-1025.
18. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science. 2002;298:1759-1762.
19. Wu H, Zhu H, Zhuang J, Yang S, Liu C, Cao YC. Water-soluble nanocrystals through dual-interaction ligands. Angew Chem Int Ed Engl. 2008;47:3730-3734.
20. Ehrhardt GJ, Welch MJ. A new germanium-63/gallium-68 generator. J Nucl Med. 1978;19:925-929.
21. 68Ga for medical application. J Nucl Med. 2007;48:1741-1748.
22. 68Ga and investigation of in vitro properties. Nucl Med Mol Imaging. 2009;43:330-336.
23. 68Ga-labeled radiopharmaceuticals for positron emission tomography. Nucl Med Mol Imaging. 2010;44:233-240.
24. Schottelius M, Laufer B, Kessler H, Wester HJ. Ligands for mapping alphav-beta3-integrin expression in vivo. Acc Chem Res. 2009;42:969-980.
25. 68Ga-labeled c(RGDyK)- isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid and feasibility studies in mice. J Nucl Med. 2008;49:830-836.
26. Cai W, Chen K, Li ZB, Gambhir SS, Chen X. Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. J Nucl Med. 2007;48:1862-1870.
27. Cai W, Chen X. Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging. Nat Protoc. 2008;3:89-96.
28. Choi HS, Liu W, Liu F, et al. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol. 2010;5:42-47.
29. Temming K, Schiffelers RM, Molema G, Kok RJ. RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist Updat. 2005;8:381-402.
30. Magnusson S, Berg T. Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells. Biochem J. 1989;257:651-656.
31. 99mTc-MSA) as a novel receptor binding agent for sentinel lymph node imaging. Nucl Med Commun. 2004;25:1211-1217.
32. 99mTc-neoglycosylated human serum albumins. Arch Pharm Res. 2008;31:60-66.
33. 68Ga-labeled mannosylated human serum albumin (MSA) as a lymph node imaging agent for positron emission tomography. Nucl Med Biol. 2011;38:371-379.
34. Krohn KA, Vera DR, Steffen SM. Neogalactoalbumin-Tc-99: a general-model for some bifunctional carbohydrates. J Label Compd Radiopharm. 1981;18:91-93.
35. 99mTc-neolactosylated human serum albumin for imaging the hepatic asialoglycoprotein receptor. Bioconjug Chem. 2004;15:850-855.
36. Parker D. Tumor targeting with radiolabelled macrocycle-antibody conjugates. Chem Soc Rev. 1990;19:271-291.
37. Kiessling F, Huppert J, Zhang C, et al. RGD-labeled USPIO inhibits adhesion and endocytotic activity of alphav beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment. Radiology. 2009;253: 462-469.
38. Ma P, Liu S, Huang YB, Chen XS, Zhang LP, Jing XB. Lactose mediated liver-targeting effect observed by ex vivo imaging technology. Biomaterials. 2010;31:2646-2654.