LDL-cholesterol and insulin are independently associated with body mass index in adult cystic fibrosis patients

Journal of Cystic Fibrosis

Volumn 11, Issue 5, 2012, Pages 393-397

  Coderre, Lise ^a,b   Fadainia, Christophe ^a   Belson, Linda ^a,b   Belisle, Virginie ^a   Ziai, Sophie ^a,b   Maillhot, Geneviève ^b,d   Berthiaume, Yves ^b,c   Rabasa Lhoret, Rémi ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Body mass index; Cystic fibrosis; Insulin; LDL cholesterol; Lung function

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CYSTIC FIBROSIS; DIET RESTRICTION; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; UNDERWEIGHT;

ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; CYSTIC FIBROSIS; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; OVERWEIGHT; RESPIRATORY FUNCTION TESTS;

EID: 84866171985     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2012.03.006     Document Type: Article

References (35)

1. Dupuis A., Hamilton D., Cole D.E., Corey M. Cystic fibrosis birth rates in Canada: a decreasing trend since the onset of genetic testing. J Pediatr Sep 2005, 147(3):312-315.
2. Borowitz D. The interrelationship of nutrition and pulmonary function in patients with cystic fibrosis. Curr Opin Pulm Med Nov 1996, 2(6):457-461.
3. Jarad N.A., Higgs S., Jeffcote T., Giles K. Factors associated with reduced FEV1 in adult patients with cystic fibrosis in a relatively affluent area. Chron Respir Dis 2005, 2(3):133-137.
4. Pedreira C.C., Robert R.G., Dalton V., Oliver M.R., Carlin J.B., Robinson P., et al. Association of body composition and lung function in children with cystic fibrosis. Pediatr Pulmonol Mar 2005, 39(3):276-280.
5. Snell G.I., Bennetts K., Bartolo J., Levvey B., Griffiths A., Williams T., et al. Body mass index as a predictor of survival in adults with cystic fibrosis referred for lung transplantation. J Heart Lung Transplant Nov 1998, 17(11):1097-1103.
6. Courtney J.M., Bradley J., Mccaughan J., O'Connor T.M., Shortt C., Bredin C.P., et al. Predictors of mortality in adults with cystic fibrosis. Pediatr Pulmonol Jun 2007, 42(6):525-532.
7. Canadian Cystic Fibrosis Patient Data Registry Report http://www.cysticfibrosis.ca/assets/files/pdf/CPDR_ReportE.pdf.
8. Costa M., Potvin S., Hammana I., Malet A., Berthiaume Y., Jeanneret A., et al. Increased glucose excursion in cystic fibrosis and its association with a worse clinical status. J Cyst Fibros Nov 30, 2007, 6(6):376-383.
9. Kristidis P., Bozon D., Corey M., Markiewicz D., Rommens J., Tsui L.C., et al. Genetic determination of exocrine pancreatic function in cystic fibrosis. Am J Hum Genet Jun 1992, 50(6):1178-1184.
10. Clain J., Lehmann-Che J., Dugueperoux I., Arous N., Girodon E., Legendre M., et al. Misprocessing of the CFTR protein leads to mild cystic fibrosis phenotype. Hum Mutat Apr 2005, 25(4):360-371.
11. Ooi C.Y., Dorfman R., Cipolli M., Gonska T., Castellani C., Keenan K., et al. Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis. Gastroenterology Jan 2011, 140(1):153-161.
12. Castellani C., Cuppens H., Macek M., Cassiman J.J., Kerem E., Durie P., et al. Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice. J Cyst Fibros May 2008, 7(3):179-196.
13. Canadian Diabetes Association Clinical Practice Guidelines http://www.diabetes.ca/for-professionals/resources/2008-cpg.
14. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem Jun 1972, 18(6):499-502.
15. Leiter L.A., Fitchett D.H., Gilbert R.E., Gupta M., Mancini G.B., McFarlane P.A., et al. Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group. Can J Cardiol Mar 2011, 27(2):e1-e33.
16. Hollander F. Dietary treatment of adult patients with cystic fibrosis related diabetes http://www.cfww.org/docs/pub/edition12/03_dietary.pdf.
17. Kerem E., Conway S., Elborn S., Heijerman H. Standards of care for patients with cystic fibrosis: a European consensus. J Cyst Fibros Mar 2005, 4(1):7-26.
18. Weintraub A., Blau H., Mussaffi H., Picard E., Bentur L., Kerem E., et al. Exocrine pancreatic function testing in patients with cystic fibrosis and pancreatic sufficiency: a correlation study. J Pediatr Gastroenterol Nutr Mar 2009, 48(3):306-310.
19. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA May 16, 2001, 285(19):2486-2497.
20. Stallings V.A., Stark L.J., Robinson K.A., Feranchak A.P., Quinton H. Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review. J Am Diet Assoc May 2008, 108(5):832-839.
21. Kastner-Cole D., Palmer C.N., Ogston S.A., Mehta A., Mukhopadhyay S. Overweight and obesity in deltaF508 homozygous cystic fibrosis. J Pediatr Sep 2005, 147(3):402-404.
22. Ionescu A.A., Nixon L.S., Luzio S., Lewis-Jenkins V., Evans W.D., Stone M.D., et al. Pulmonary function, body composition, and protein catabolism in adults with cystic fibrosis. Am J Respir Crit Care Med Feb 15, 2002, 165(4):495-500.
23. Ionescu A.A., Nixon L.S., Evans W.D., Stone M.D., Lewis-Jenkins V., Chatham K., et al. Bone density, body composition, and inflammatory status in cystic fibrosis. Am J Respir Crit Care Med Sep 2000, 162(3 Pt 1):789-794.
24. Sharma R., Florea V.G., Bolger A.P., Doehner W., Florea N.D., Coats A.J., et al. Wasting as an independent predictor of mortality in patients with cystic fibrosis. Thorax Oct 2001, 56(10):746-750.
25. Moran A., Pekow P., Grover P., Zorn M., Slovis B., Pilewski J., et al. Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial. Diabetes Care Oct 2009, 32(10):1783-1788.
26. Mohan K., Israel K.L., Miller H., Grainger R., Ledson M.J., Walshaw M.J. Long-term effect of insulin treatment in cystic fibrosis-related diabetes. Respiration 2008, 76(2):181-186.
27. Ripa P., Robertson I., Cowley D., Harris M., Masters I.B., Cotterill A.M. The relationship between insulin secretion, the insulin-like growth factor axis and growth in children with cystic fibrosis. Clin Endocrinol (Oxf) Mar 2002, 56(3):383-389.
28. Vyroubal P., Chiarla C., Giovannini I., Hyspler R., Ticha A., Hrnciarikova D., et al. Hypocholesterolemia in clinically serious conditions-review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Dec 2008, 152(2):181-189.
29. Dunham C.M., Fealk M.H., Sever W.E. Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. Crit Care Dec 2003, 7(6):R145-R153.
30. Vermont C.L., den B.M., Kakeci N., de Kleijn E.D., de Rijke Y.B., Joosten K.F., et al. Serum lipids and disease severity in children with severe meningococcal sepsis. Crit Care Med Jul 2005, 33(7):1610-1615.
31. Fraunberger P., Schaefer S., Werdan K., Walli A.K., Seidel D. Reduction of circulating cholesterol and apolipoprotein levels during sepsis. Clin Chem Lab Med Mar 1999, 37(3):357-362.
32. Guimaraes S.M., Lima E.Q., Cipullo J.P., Lobo S.M., Burdmann E.A. Low insulin-like growth factor-1 and hypocholesterolemia as mortality predictors in acute kidney injury in the intensive care unit. Crit Care Med Dec 2008, 36(12):3165-3170.
33. Chiang C.K., Ho T.I., Hsu S.P., Peng Y.S., Pai M.F., Yang S.Y., et al. Low-density lipoprotein cholesterol: association with mortality and hospitalization in hemodialysis patients. Blood Purif 2005, 23(2):134-140.
34. Obialo C.I., Okonofua E.C., Nzerue M.C., Tayade A.S., Riley L.J. Role of hypoalbuminemia and hypocholesterolemia as copredictors of mortality in acute renal failure. Kidney Int Sep 1999, 56(3):1058-1063.
35. Pacelli F., Doglietto G.B., Alfieri S., Piccioni E., Sgadari A., Gui D., et al. Prognosis in intra-abdominal infections. Multivariate analysis on 604 patients. Arch Surg Jun 1996, 131(6):641-645.