The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells

Cellular Oncology

Volumn 35, Issue 1, 2012, Pages 1-8

  Park, Seok Woo ^a   Heo, Dae Seog ^a   Sung, Myung Whun ^a  

^a Seoul National University   (South Korea)

Author keywords

5 Lipoxygenase; Cyclooxygenase 2; CYP2J2; Head and neck cancer

Indexed keywords

ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYTOCHROME P450 2J2; CYTOCHROME P450 INHIBITOR; EPOXYICOSATRIENOIC ACID; LEUKOTRIENE B4; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; SMALL INTERFERING RNA; VASCULOTROPIN; 14,15 DIHYDROXYEICOSATRIENOIC ACID; 14,15-DIHYDROXYEICOSATRIENOIC ACID; ANTINEOPLASTIC AGENT; ARACHIDONATE EPOXYGENASE; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450; DIHOMO GAMMA LINOLENIC ACID; DRUG DERIVATIVE; PROSTAGLANDIN E2; PTGS2 PROTEIN, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; ENZYME INHIBITION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; PLASMID; TUMOR CELL LINE;

8,11,14-EICOSATRIENOIC ACID; ANTINEOPLASTIC AGENTS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CELL LINE, TUMOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DINOPROSTONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; LEUKOTRIENE B4; PLASMIDS; RNA, SMALL INTERFERING; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866167685     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-011-0051-7     Document Type: Article

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