Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa

International Journal of Andrology

Volumn 35, Issue 5, 2012, Pages 633-644

  Sagare Patil, V ^a   Galvankar, M ^a   Satiya, M ^a   Bhandari, B ^b   Gupta, S K ^b   Modi, D ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Acrosome reaction; Calcium channels; Hyperactivation; Kinase; Mibefradil; Motility; Phosphorylation; Progesterone; Spermatozoa

Indexed keywords

CALCIUM; MIBEFRADIL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROGESTERONE; PROTEIN KINASE B; PROTEIN P90; PROTEIN TYROSINE KINASE; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1;

ACROSOME; ACROSOME REACTION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPERMATOZOON; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; STRESS;

ACROSOME REACTION; CALCIUM CHANNELS, T-TYPE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MIBEFRADIL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROGESTERONE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SPERM CAPACITATION; SPERM MOTILITY; SPERMATOZOA;

EID: 84866158918     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2012.01291.x     Document Type: Article

References (31)

1. Aitken RJ, Buckingham DW, Harkiss D, Paterson M, Fisher H & Irvine DS. (1996) The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation. Mol Cell Endocrinol 117, 83-93.
2. Baldi E, Luconi M, Bonaccorsi L & Forti G. (1998) Nongenomic effects of progesterone on spermatozoa: Mechanisms of signal transduction and clinical implications. Front Biosc 3, d1051-d1059.
3. Baldi E, Luconi M & Forti G. (2009) Nongenomic activation of spermatozoa by steroid hormones: Facts and functions. Mol Cell Endocrinol 308, 39-46.
4. 2+](i) mobilization and cell response in human spermatozoa exposed to progesterone. Dev Biol 302, 324-332.
5. Bhandari B, Bansal P, Talwar P & Gupta SK. (2010) Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida. Reprod Biol Endocrinol 8, 7.
6. Blengini CS, Teves ME, Uñates DR, Guidobaldi HA, Gatica LV & Giojalas LC. (2011) Human sperm pattern of movement during chemotactic re-orientation towards a progesterone source. Asian J Androl 13, 769-773.
7. Bonaccorsi L, Forti G & Baldi E. (2001) Low-voltage-activated calcium channels are not involved in capacitation and biological response to progesterone in human sperm. Int J Androl 24, 341-351.
8. Calogero AE, Hall J, Fishel S, Green S, Hunter A & D'Agata R. (1996) Effects of gamma-aminobutyric acid on human sperm motility and hyperactivation. Mol Hum Reprod 2, 733-738.
9. Chang H & Suarez SS. (2010) Rethinking the relationship between hyperactivation and chemotaxis in mammalian sperm. Biol Reprod 83, 507-513.
10. Contreras HR & Llanos MN. (2001) Detection of progesterone receptors in human spermatozoa and their correlation with morphological and functional properties. Int J Androl 24, 246-252.
11. De Jonge C. (2005) Biological basis for human capacitation. Hum Reprod Update 11, 205-214.
12. Garcia MA & Meizel S. (1999) Progesterone-mediated calcium influx and acrosome reaction of human spermatozoa: Pharmacological investigation of T-type calcium channels. Biol Reprod 60, 102-109.
13. Godbole GB, Modi DN & Puri CP. (2007) Regulation of homeobox A10 expression in primate endometrium by progesterone and embryonic stimuli. Reproduction 134, 513-523.
14. Harper CV, Barratt CL & Publicover SJ. (2004) Stimulation of human spermatozoa with progesterone gradients to simulate approach to the oocyte. J Biol Chem 279, 46315-46325.
15. Harrison DA, Carr DW & Meizel S. (2000) Involvement of protein kinase A and A kinase anchoring proteins in the progesterone initiated human sperm acrosome reaction. Biol Reprod 62, 811-820.
16. Jaiswal BS, Tur-Kaspa I, Dor J, Mashiach S & Eisenbach M. (1999) Human sperm chemotaxis: Is progesterone a chemoattractant? Biol Reprod 60, 1314-1319.
17. Jin M, Fujiwara E, Kakiuchi Y, Okabe M, Satouh Y, Baba SA, Chiba K & Hirohashi N. (2011) Most fertilizing mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in vitro fertilization. Proc Natl Acad Sci USA 108, 4892-4896.
18. 2+ channel of human sperm. Nature 471, 387-391.
19. Luconi M, Bonaccorsi L, Maggi M, Pecchioli P, Krausz C, Forti G & Baldi E. (1998a) Identification and characterization of functional non-genomic progesterone receptors on human sperm membrane. J Clin Endocrinol Metab 83, 877-885.
20. Luconi M, Krausz C, Barni T, Vannelli GB, Forti G & Baldi E. (1998b) Progesterone stimulates p42 extracellular signal-regulated kinase (p42erk) in human spermatozoa. Mol Hum Reprod 4, 251-258.
21. Oren-Benaroya R, Orvieto R, Gakamsky A, Pinchasov M & Eisenbach M. (2008) The sperm chemoattractant secreted from human cumulus cells is progesterone. Hum Reprod 10, 2339-2345.
22. O'Toole CM, Roldan ER & Fraser LR. (1996) Protein kinase C activation during progesterone-stimulated acrosomal exocytosis in human spermatozoa. Mol Hum Reprod 2, 921-927.
23. 2+ signalling in the control of motility and guidance in mammalian sperm. Front Biosci. 13, 5623-5637.
24. Senuma M, Yamano S, Nakagawa K, Irahara M, Kamada M & Aono T. (2001) Progesterone accelerates the onset of capacitation in mouse sperm via T-type calcium channels. Arch Androl 47, 127-134.
25. Shah CA, Modi D, Gadkar S, Sachdeva G, D' SS & Puri CP. (2005) N-terminal region of progesterone receptor B isoform in human spermatozoa. Int J Androl 28, 360-371.
26. Shi QX & Roldan ER. (1995) Evidence that a GABAA-like receptor is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa. Biol Reprod 52, 373-381.
27. 2+ influx in human sperm. Nature 471, 382-386.
28. Tesarik J, Moos J & Mendoza C. (1993) Stimulation of protein tyrosine phosphorylation by a progesterone receptor on the cell surface of human sperm. Endocrinology 133, 328-335.
29. Teves ME, Barbano F, Guidobaldi HA, Sanchez R, Miska W & Giojalas LC. (2006) Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa. Fertil Steril 86, 745-749.
30. Teves ME, Guidobaldi HA, Uñates DR, Sanchez R, Miska W, Publicover SJ, Morales Garcia AA & Giojalas LC. (2009) Molecular mechanism for human sperm chemotaxis mediated by progesterone. PLoS ONE 4, e8211.
31. Uhler ML, Leung A, Chan SY & Wang C. (1992) Direct effects of progesterone and antiprogesterone on human sperm hyperactivated motility and acrosome reaction. Fertil Steril 58, 1191-1198.