CDK9 and H2B Monoubiquitination: A Well-Choreographed Dance

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Johnsen, Steven A ^a,b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 9; ELONGATION FACTOR; HISTONE H2B; MESSENGER RNA; NEGATIVE ELONGATION FACTOR E; PROTEIN; PROTEIN RAD6; PROTEIN SER2; PROTEIN SUPPRESSOR OF TY 5; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; FEEDBACK SYSTEM; GENETIC ASSOCIATION; HISTONE MODIFICATION; HUMAN; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RNA PROCESSING; RNA TRANSLATION; SCHIZOSACCHAROMYCES POMBE; TRANSCRIPTION REGULATION; UBIQUITINATION; YEAST;

CYCLIN-DEPENDENT KINASE 9; HISTONES; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RNA, MESSENGER; SCHIZOSACCHAROMYCES; TRANSCRIPTION ELONGATION, GENETIC;

EID: 84866157104     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002860     Document Type: Article

References (27)

1. Strahl BD, Allis CD, (2000) The language of covalent histone modifications. Nature 403: 41-45.
2. Peterlin BM, Price DH, (2006) Controlling the elongation phase of transcription with P-TEFb. Mol Cell 23: 297-305 doi:10.1016/j.molcel.2006.06.014.
3. Wood A, Shilatifard A, (2006) Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb. Cell Cycle 5: 1066-1068.
4. Sansó M, Lee KM, Viladevall L, Jacques P-É, Pagé V, et al. (2012) A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genet 8: e1002822 doi:10.1371/journal.pgen.1002822.
5. Pirngruber J, Shchebet A, Johnsen SA, (2009) Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. Cell Cycle 8: 3636-3642.
6. Egloff S, Murphy S, (2008) Cracking the RNA polymerase II CTD code. Trends Genet 24: 280-288.
7. Yamada T, Yamaguchi Y, Inukai N, Okamoto S, Mura T, et al. (2006) P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol Cell 21: 227-237.
8. Zhou K, Kuo WH, Fillingham J, Greenblatt JF, (2009) Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5. Proc Natl Acad Sci U S A 106: 6956-6961 doi:10.1073/pnas.0806302106.
9. Shchebet A, Karpiuk O, Kremmer E, Eick D, Johnsen SA, (2012) Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. Cell Cycle 11: 2122-2127.
10. Wood A, Schneider J, Dover J, Johnston M, Shilatifard A, (2005) The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell 20: 589-599.
11. Fujinaga K, Irwin D, Huang Y, Taube R, Kurosu T, et al. (2004) Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. Mol Cell Biol 24: 787-795.
12. Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H, (2002) Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol 22: 2918-2927.
13. Johnsen SA, (2012) The enigmatic role of H2Bub1 in cancer. FEBS Lett 586: 1592-1601 doi:10.1016/j.febslet.2012.04.002.
14. Minsky N, Shema E, Field Y, Schuster M, Segal E, et al. (2008) Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat Cell Biol 10: 483-488.
15. Xiao T, Kao CF, Krogan NJ, Sun ZW, Greenblatt JF, et al. (2005) Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol 25: 637-651.
16. Pavri R, Zhu B, Li G, Trojer P, Mandal S, et al. (2006) Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell 125: 703-717.
17. Briggs SD, Xiao T, Sun ZW, Caldwell JA, Shabanowitz J, et al. (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418: 498 doi:10.1038/nature00970.
18. Ng HH, Xu RM, Zhang Y, Struhl K, (2002) Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem 277: 34655-34657 doi:10.1074/jbc.C200433200.
19. Sun ZW, Allis CD, (2002) Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418: 104-108.
20. Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, et al. (2012) The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Mol Cell 46: 705-713.
21. Shema E, Tirosh I, Aylon Y, Huang J, Ye C, et al. (2008) The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev 22: 2664-2676.
22. Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, et al. (2009) CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3′ end processing. EMBO Rep 10: 894-900.
23. Zhang F, Yu X, (2011) WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Mol Cell 41: 384-397.
24. Laribee RN, Krogan NJ, Xiao T, Shibata Y, Hughes TR, et al. (2005) BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr Biol 15: 1487-1493.
25. Chen Y, Yamaguchi Y, Tsugeno Y, Yamamoto J, Yamada T, et al. (2009) DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev 23: 2765-2777 doi:10.1101/gad.1834709.
26. Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev 24: 2303-2316 doi:10.1101/gad.1968210.
27. Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev 25: 2158-2172 doi:10.1101/gad.16962311.