Multicenter, Randomized, Open-Label Study Comparing the Efficacy and Safety of Micafungin versus Itraconazole for Prophylaxis of Invasive Fungal Infections in Patients undergoing Hematopoietic Stem Cell Transplant

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 10, 2012, Pages 1509-1516

  Huang, Xiaojun ^a   Chen, Huan ^a   Han, Mingzhe ^b   Zou, Ping ^c   Wu, Depei ^d   Lai, Yongrong ^e   Huang, He ^f   Chen, Xiequn ^g   Liu, Ting ^h   Zhu, Huanling ^h   Wang, Jianmin ⁱ   Hu, Jianda ^j  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING   (China)

^d THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^e FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^f ZHEJIANG UNIVERSITY   (China)

^g FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^h Research Center of Medical Sciences   (China)

ⁱ SECOND MILITARY MEDICAL UNIVERSITY   (China)

^j FUJIAN MEDICAL UNIVERSITY   (China)

more..

Author keywords

Antifungal prophylaxis; Hematopoietic stem cell transplant; Itraconazole; Micafungin; Prevention of invasive fungal infection

Indexed keywords

ITRACONAZOLE; MICAFUNGIN;

ADULT; ARTICLE; CHINA; CONFIDENCE INTERVAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FEVER; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOLYSIS; HUMAN; HYPONATREMIA; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA AND VOMITING; NEUTROPENIA; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SYSTEMIC MYCOSIS;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ANTIFUNGAL AGENTS; DRUG ADMINISTRATION SCHEDULE; ECHINOCANDINS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; ITRACONAZOLE; LIPOPEPTIDES; MALE; MIDDLE AGED; MYCOSES; NEUTROPENIA; TREATMENT OUTCOME;

EID: 84866148545     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2012.03.014     Document Type: Article

References (14)

1. Winston D.J., Maziarz R.T., Chandrasekar P.H., et al. Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trial. Ann Intern Med 2003, 138:705-713.
2. Marr K.A., Crippa F., Leisenring W., et al. Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. Blood 2004, 103:1527-1533.
3. van Burik J.A., Ratanatharathorn V., Stepan D.E., et al. Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation. Clin Infect Dis 2004, 39:1407-1416.
4. Hirata Y., Yokote T., Kobayashi K., et al. Antifungal prophylaxis with micafungin in neutropenic patients with hematological malignancies. Leuk Lymphoma 2010, 51:853-859.
5. McCoy D., Depestel D.D., Carver P.L. Primary antifungal prophylaxis in adult hematopoietic stem cell transplant recipients: current therapeutic concepts. Pharmacotherapy 2009, 29:1306-1325.
6. Shen Z.X. [Diagnostic criteria and therapeutic principles of invasive fungal infection in patients with hematological diseases or malignant tumors]. [Article in Chinese]. Zhonghua Nei Ke Za Zhi 2007, 46:532-533.
7. Bormann A.M., Morrison V.A. Review of the pharmacology and clinical studies of micafungin. Drug Des Devel Ther 2009, 3:295-302.
8. Temesgen Z., Barreto J., Vento S. Micafungin - the newest echinocandin. Drugs Today 2009, 45:469-478.
9. Hashino S., Morita L., Takahata M., et al. Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation. Int J Hematol 2008, 87:91-97.
10. Hiramatsu Y., Maeda Y., Fujii N., et al. Use of micafungin versus fluconazole for antifungal prophylaxis in neutropenic patients receiving hematopoietic stem cell transplantation. Int J Hematol 2008, 88:588-595.
11. Bow E.J., Laverdière M., Lussier N., Rotstein C., Cheang M.S., Ioannou S. Antifungal prophylaxis for severely neutropenic chemotherapy recipients: a meta analysis of randomized-controlled clinical trials. Cancer 2002, 94:3230-3246.
12. Robenshtok E., Gafter-Gvili A., Goldberg E., et al. Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis. J Clin Oncol 2007, 25:5471-5489.
13. Kontoyiannis D.P. Antifungal prophylaxis in hematopoietic stem cell transplant recipients: the unfinished tale of imperfect success. Bone Marrow Transplant 2011, 46:165-173.
14. Glasmacher A., Prentice A., Gorschlüter M., et al. Itraconazole prevents invasive fungal infections in neutropenic patients treated for hematologic malignancies: evidence from a meta-analysis of 3,597 patients. J Clin Oncol 2003, 21:4615-4626.