Efficacy of infliximab in a rabbit model of osteoarthritis

Connective Tissue Research

Volumn 53, Issue 5, 2012, Pages 355-358

  Zhang, Qiankun ^a   Lv, Hong Hua ^a   Chen, Aqiong ^b   Liu, Feijun ^a   Wu, Xuelian ^a  

^a LISHUI UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Infliximab; Intra articular injection; Osteoarthritis; Rabbit model; TNF

Indexed keywords

INFLIXIMAB; INTERLEUKIN 1BETA; NITRIC OXIDE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR CRUCIATE LIGAMENT INJURY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; HISTOPATHOLOGY; KNEE MENISCUS RUPTURE; NONHUMAN; OSTEOARTHRITIS; RABBIT; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYNOVIAL FLUID;

ANIMALS; ANTIBODIES, MONOCLONAL; CARTILAGE; DISEASE MODELS, ANIMAL; FEMALE; FEMUR; INTERLEUKIN-1BETA; MALE; NITRIC OXIDE; OSTEOARTHRITIS; RABBITS; SYNOVIAL FLUID; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 84866136089     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2012.661001     Document Type: Article

References (20)

1. Fernandes, J.C., Martel-Pelletier, J., and Pelletier, J.P. (2002). The role of cytokines in osteoarthritis pathophysiology. Biorheology 39(1-2): 237-246. (Pubitemid 34626067)
2. Loeser, R.F. (2008). Molecular mechanisms of cartilage destruction in osteoarthritis. J. Musculoskelet. Neuronal. Interact. 8(4):303-306.
3. Lapaj, L., Markuszewski, J., and Wierusz-Kozlowska, M. (2010). Current views on the pathogenesis of osteoarthritis. Chir. Narzadow. Ruchu. Ortop. Pol. 75(4):248-260.
4. Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J.P., and Fahmi, H. (2011). Role of proinflammatory cytokines in the pathophy-siology of osteoarthritis. Nat. Rev. Rheumatol. 7(1):33-42.
5. Bondeson, J., Wainwright, S.D., Lauder, S., Amos, N., and Hughes, C.E. (2006). The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res. Ther. 8(6):R187.
6. Goldring, M.B. (1999). The role of cytokines as inflammatory mediators in osteoarthritis: Lessons from animal models. Connect. Tissue Res. 40(1):1-11. (Pubitemid 29139343)
7. Hulth, A., Lindberg, L., and Telhag, H. (1970). Experimental osteoarthri-tis in rabbits. Preliminary report. Acta Orthop. Scand. 41(5):522-530.
8. van der Sluijs, J.A., Geesink, R.G., van der Linden, A.J., Bulstra, S.K., Kuyer, R., and Drukker, J. (1992). The reliability of the Mankin score for osteoarthritis. J. Orthop. Res. 10(1):58-61.
9. Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., and Tannenbaum, S.R. (1982). Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 126(1):131-138. (Pubitemid 13203451)
10. Clancy, R.M., Amin, A.R., and Abramsom, S.B. (1998). The role of nitric oxide in inflammation and immunity. Arthritis Rheum. 41:1141-1151. (Pubitemid 28313414)
11. Lotz, M. (1999). The role of nitric oxide in articular cartilage damage. Rheum. Dis. Clin. North Am. 25:269-282. (Pubitemid 29267883)
12. Rajamaki, M.M., and Sorsa, T. (2006). Osteoarthritis: Linking nitric oxide and metalloproteinases in canine articular ligament pathology. Vet. J. 172(3):400-401. (Pubitemid 44575927)
13. White, W.B., Pepine, C.J., and Weber, M.A. (2009). The potential role of nitric oxide in cardiovascular safety when treating patients with osteoar-thritis and hypertension: A moderated panel discussion. Am. J. Med. 122(5):S23-S25.
14. Fernandes, J.C., Tardif, G., Martel-Pelletier, J., Lascau-Coman, V., Dupuis, J., Moldovan, F., Sheppard, M., Krishnan, B.R., and Pelletier, J.P. (1999). In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: Prevention of osteoarthritic progression. Am. J. Pathol. 154:1535-1544.
15. Frisbie, D.D., Ghivizzani, S.C., Robbins, P.D., Evans, C.H., and McIlwraith, C.W. (2002). Treatment of experimental equine osteoar-thritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther. 9:12-20. (Pubitemid 34145163)
16. Chevalier, X., Goupille, P., Beaulieu, A.D., Burch, F.X., Bensen, W.G., Conrozier, T., Loeuille, D., Kivitz, A.J., Silver, D., and Appleton, B.E. (2009). Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 61:344-352.
17. Grunke, M., and Schulze-Koops, H. (2006). Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade. Ann. Rheum. Dis. 65(4):555-556.
18. Magnano, M.D., Chakravarty, E.F., Broudy, C., Chung, L., Kelman, A., Hillygus, J., and Genovese, M.C. (2007). A pilot study of tumor necrosis factor inhibition in erosive/inflammatory osteoarthritis of the hands. J. Rheumatol. 34(6):1323-1327. (Pubitemid 46898115)
19. Fioravanti, A., Fabbroni, M., Cerase, A., and Galeazzi, M. (2009). Treatment of erosive osteoarthritis of the hands by intra-articular inflix-imab injections: A pilot study. Rheumatol. Int. 29(8):961-965.
20. Vuolteenaho, K., Moilanen, T., Hamalainen, M., and Moilanen, E. (2002). Effects of TNFalpha-antagonists on nitric oxide production in human cartilage. Osteoarthritis Cartilage 10(4):327-332. (Pubitemid 34467637)