Elevation in D-dimer concentrations is positively correlated with gestation in normal uncomplicated pregnancy

International Journal of Women's Health

Volumn 4, Issue 1, 2012, Pages 437-443

  Jeremiah, Zaccheaus A ^a   Adias, Teddy C ^b   Opiah, Margaret ^a   George, Siyeoforiye P ^c   Mgbere, Osaro ^d   Essien, Ekere J ^e  

^a NIGER DELTA UNIVERSITY   (Nigeria)

^b Bayelsa State College of Health Technology   (Nigeria)

^c RIVERS STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Nigeria)

^d Houston Department of Health and Human Services   (United States)

^e UNIVERSITY OF HOUSTON   (United States)

Author keywords

Activated partial thromboplastin time; D dimer; Nigeria; Pregnancy; Prothrombin time

Indexed keywords

D DIMER; HEMOGLOBIN;

ADOLESCENT; ADULT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; INTERNATIONAL NORMALIZED RATIO; NIGERIA; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PREGNANCY; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; RISK ASSESSMENT; THROMBOCYTE COUNT; THROMBOSIS;

EID: 84866135244     PISSN: None     EISSN: 11791411     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hoffbrand AV, Pettit JE, Moss PAH. Essential Hematology, 4th ed. Oxford: Blackwell Science; 2002.
2. Prisco D, Cam G, Falcani M. Hemostatic changes in normal pregnancy. Haematol Meet Rep. 2005;1:1-5.
3. Higgins C. D-dimer measurement: a novel use for an established test? The Biomedical Scientist. 2008;52:1049-1051.
4. Kline JA, Williams GW, Hernandez-Nino J. D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed. Clin Chem. 2005;51:825-829.
5. Boehlen F, Epiney M, Boulvain M, Irion O, de Moerloose P. [Changes in D-dimer levels during pregnancy and the postpartum period: results of two studies]. Rev Med Suisse. 2005;1:296-298. French.
6. Francalanci I, Comeglio P, Allessandrello Liotta A, et al. D-dimer plasma levels during normal pregnancy measured by specific ELISA. Intl J Clin Lab Res. 1997;27:65-67.
7. ICSH. International Committee for Standardization in Haematology handbook. 1986:7.
8. Planner G, Kilgert K. Obstetric bleeding complications. Hamostaseologie. 2006;26(Suppl 1):S56-S63.
9. Marik PE, Plante LA. Venous thromboembolic disease and pregnancy. N Engl J Med. 2008;359:2025-2033.
10. Nijkeuter M, Huisman MV. Diagnosing pulmonary embolism in pregnancy: Is there a role for D-dimer as a stand-alone test? Crit Care Med. 2006;34:2701-2702.
11. Nelson-Piercy C. Thromboprophylaxis during pregnancy, labour and after vaginal delivery. Guidelines 37. London: Royal College of Obstetricians and Gynaecologists; 2004.
12. Nolan T, Smith R, Devoe L. Maternal plasma D-dimer levels in normal and complicated pregnancies. Obstet Gynecol. 1993;81:235-238.
13. Morse M. Establishing a normal range for D-dimer levels through pregnancy to aid in the diagnosis of pulmonary embolism and deep vein thrombosis. J Thromb Haemost. 2004;2:1202-1204.
14. Bellart J, Gilabert R, Fontcuberta J, Carreras E, Miralles RM, Cabero L. Coagulation and fibrinolysis parameters in normal pregnancy and in gestational diabetes. Am J Perinatol. 1998:15:479-486.
15. Buseri FI, Jeremiah ZA, Kalio FG. Influence of pregnancy and gestation period on some coagulation parameters among Nigerian antenatal women. Res J Med Sci. 2008;2:275-281.
16. Gosselin RC, Owings JT, Jacoby RC, Larkin EC. Evaluation of a new automated quantitative d-dimer, Advanced D-dimer, in patients suspected of venous thromboembolism. Blood Coagul Fibrinolysis. 2002;13:323-330.
17. Palareti G, Cosmi B, Legnani C, et al. D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006;355: 1780-1789.
18. Shehata N, Burrows R, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol. 1999;42:327-334.
19. Levy JA, Murphy LD. Thrombocytopenia in pregnancy. J Am Board Fam Pract. 2002;15:290-297.