Trouble at Rest: How Correlation Patterns and Group Differences Become Distorted After Global Signal Regression

Brain Connectivity

Volumn 2, Issue 1, 2012, Pages 25-32

  Saad, Ziad S ^a   Gotts, Stephen J ^a   Murphy, Kevin ^b   Chen, Gang ^a   jo, Hang Joon ^a   Martin, Alex ^a   Cox, Robert W ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

brain networks; connectome; correlation matrix; functional connectivity; functional connectivity magnetic resonance imaging (fcMRI)

Indexed keywords

EID: 84866121509     PISSN: 21580014     EISSN: 21580022     Source Type: Journal    
DOI: 10.1089/brain.2012.0080     Document Type: Article

References (32)

1. Anderson J.S., Druzgal T.J., Froehlich A, DuBray M.B., Lange N, Alexander A.L., Abildskov T, Nielsen J.A., Cariello A.N., Cooperrider J.R., Bigler E.D., Lainhart JE. 2011a. Decreased interhemispheric functional connectivity in autism. Cereb Cortex 21:1134-1146.
2. Anderson J.S., Druzgal T.J., Lopez-Larson M, Jeong E.K., Desai K, Yurgelun-Todd D. 2011b. Network anticorrelations, global regression, and phase-shifted soft tissue correction. Hum Brain Mapp 32:919-934.
3. Beall EB. 2010. Adaptive cyclic physiologic noise modeling and correction in functional MRI. J Neurosci Methods 187:216-228.
4. Beall E.B., Lowe MJ. 2007. Isolating physiologic noise sources with independently determined spatial measures. Neuroimage 37:1286-1300.
5. Behzadi Y, Restom K, Liau J, Liu TT. 2007. A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage 37:90-101.
6. Bellec P, Rosa-Neto P, Lyttelton O.C., Benali H, Evans AC. 2010. Multi-level bootstrap analysis of stable clusters in resting-state fMRI. Neuroimage 51:1126-1139.
7. Belmonte M.K., Allen G, Beckel-Mitchener A, Boulanger L.M., Carper R.A., Webb SJ. 2004. Autism and abnormal development of brain connectivity. J Neurosci 24:9228-9231.
8. Birn R.M., Diamond J.B., Smith M.A., Bandettini PA. 2006. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI. Neuroimage 31:1536-1548.
9. Birn R.M., Murphy K, Bandettini PA. 2008. The effect of respiration variations on independent component analysis results of resting state functional connectivity. Hum Brain Mapp 29:740-750.
10. Biswal B, Yetkin F.Z., Haughton V.M., Hyde JS. 1995. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537-541.
11. Biswal B.B., Mennes M, Zuo X.N., Gohel S, Kelly C, Smith S.M., Beckmann C.F., Adelstein J.S., Buckner R.L., Colcombe S, Dogonowski A.M., Ernst M, Fair D, Hampson M, Hoptman M.J., Hyde J.S., Kiviniemi V.J., Kotter R, Li S.J., Lin C.P., Lowe M.J., Mackay C, Madden D.J., Madsen K.H., Margulies D.S., Mayberg H.S., McMahon K, Monk C.S., Mostofsky S.H., Nagel B.J., Pekar J.J., Peltier S.J., Petersen S.E., Riedl V, Rombouts S.A., Rypma B, Schlaggar B.L., Schmidt S, Seidler R.D., Siegle G.J., Sorg C, Teng G.J., Veijola J, Villringer A, Walter M, Wang L, Weng X.C., Whitfield-Gabrieli S, Williamson P, Windischberger C, Zang Y.F., Zhang H.Y., Castellanos F.X., Milham MP. 2010. Toward discovery science of human brain function. Proc Natl Acad Sci U S A 107:4734-4739.
12. Chai X.J., Castanon A.N., Ongur D, Whitfield-Gabrieli S. 2012. Anticorrelations in resting state networks without global signal regression. Neuroimage 59:1420-1428.
13. Chang C, Glover GH. 2009a. Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. Neuroimage 47:1448-1459.
14. Chang C, Glover GH. 2009b. Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI. Neuroimage 47:1381-1393.
15. Desjardins A.E., Kiehl K.A., Liddle PF. 2001. Removal of confounding effects of global signal in functional MRI analyses. Neuroimage 13:751-758.
16. Fox M.D., Greicius M. 2010. Clinical applications of resting state functional connectivity. Front Syst Neurosci 4:19.
17. Fox M.D., Zhang D, Snyder A.Z., Raichle ME. 2009. The global signal and observed anticorrelated resting state brain networks. J Neurophysiol 101:3270-3283.
18. Gee D.G., Biswal B.B., Kelly C, Stark D.E., Margulies D.S., Shehzad Z, Uddin L.Q., Klein D.F., Banich M.T., Castellanos F.X., Milham MP. 2011. Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres. Neuroimage 54:517-527.
19. Glover G.H., Li T.Q., Ress D. 2000. Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magn Reson Med 44:162-167.
20. He H, Liu TT. 2012. A geometric view of global signal confounds in resting-state functional MRI. Neuroimage 59:2339-2348.
21. Honey C.J., Sporns O, Cammoun L, Gigandet X, Thiran J.P., Meuli R, Hagmann P. 2009. Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci U S A 106:2035-2040.
22. Jo H.J., Saad Z.S., Simmons W.K., Milbury L.A., Cox RW. 2010. Mapping sources of correlation in resting state FMRI, with artifact detection and removal. Neuroimage 52:571-582.
23. Kelly C, Uddin L.Q., Shehzad Z, Margulies D.S., Castellanos F.X., Milham M.P., Petrides M. 2010. Broca's region: linking human brain functional connectivity data and non-human primate tracing anatomy studies. Eur J Neurosci 32:383-398.
24. Kundu P. 2011. T2-Dependence Distinguishes Functional Networks from Artifact Components in Individual-Subject ICA. Quebec City, Quebec, Canada: Human Brain Mapping.
25. Macey P.M., Macey K.E., Kumar R, Harper RM. 2004. A method for removal of global effects from fMRI time series. Neuroimage 22:360-366.
26. Mahani N.K., Beckmann C.F., van Osch MJP, Chang C, Gerven J.V., Rombouts SA. 2011. Is respiration modulation of resting state fmri signals noise or function? Quebec City, Quebec, Canada: Organization for Human Brain Mapping.
27. Murphy K, Birn R.M., Handwerker D.A., Jones T.B., Bandettini PA. 2009. The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44:893-905.
28. Power J.D., Barnes K.A., Snyder A.Z., Schlaggar B.L., Petersen SE. 2011. Spurious but systematic correlations in resting state functional connectivity MRI arise from head motion. Washington, DC: Society for Neuroscience.
29. Shmueli K, van Gelderen P, de Zwart J.A., Horovitz S.G., Fukunaga M, Jansma J.M., Duyn JH. 2007. Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal. Neuroimage 38:306-320.
30. Schãlvinck M.L., Maier A, Ye F.Q., Duyn J.H., Leopold DA. 2010. Neural basis of global resting-state fMRI activity. Proc Natl Acad Sci U S A 107:10238-10243.
31. Smith S.M., Fox P.T., Miller K.L., Glahn D.C., Fox P.M., Mackay C.E., Filippini N, Watkins K.E., Toro R, Laird A.R., Beckmann CF. 2009. Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci U S A 106:13040-13045.
32. Wise R.G., Ide K, Poulin M.J., Tracey I. 2004. Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal. Neuroimage 21:1652-1664.