Exploring the Mechanism of Zanamivir Resistance in a Neuraminidase Mutant: A Molecular Dynamics Study

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Han, Nanyu ^a   Liu, Xuewei ^b   Mu, Yuguang ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; SIALIDASE; ZANAMIVIR;

ARTICLE; CONFORMATION; CONTROLLED STUDY; ENERGY; ENZYME ACTIVE SITE; HYDROGEN BOND; INFLUENZA VIRUS; INFLUENZA VIRUS A H1N1; METADYNAMICS SIMULATION; MOLECULAR DYNAMICS; SIMULATION; STATIC ELECTRICITY; VIRUS MUTANT; VIRUS MUTATION; VIRUS RESISTANCE; VIRUS STRAIN;

AMINO ACIDS; APOPROTEINS; CATALYTIC DOMAIN; DRUG RESISTANCE, VIRAL; HYDROGEN BONDING; INFLUENZA A VIRUS, H1N1 SUBTYPE; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; NEURAMINIDASE; PROTEIN STRUCTURE, SECONDARY; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS; ZANAMIVIR;

ORTHOMYXOVIRIDAE;

EID: 84866106043     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044057     Document Type: Article

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