KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes

Diabetologia

Volumn 55, Issue 9, 2012, Pages 2402-2406

  Lim, X L ^a   Nurbaya, S ^a   Salim, A ^a   Tai, E S ^b   Maeda, S ^c   Nakamura, Y ^d   Ng, D P K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c RIKEN   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

ACR; Chinese; Estimated GFR; Genetics; KCNQ1; Meta analysis; Type 2 diabetes

Indexed keywords

ALBUMIN; CREATININE; POTASSIUM CHANNEL KCNQ1;

ALBUMINURIA; ARTICLE; CHINESE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DISEASE SEVERITY; FEMALE; GENE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GLOMERULUS FILTRATION RATE; HUMAN; JAPANESE; KCNQ1 GENE; KIDNEY FUNCTION; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SEX DIFFERENCE; SINGAPORE; SINGLE NUCLEOTIDE POLYMORPHISM; URINALYSIS;

AGED; ALBUMINURIA; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; COHORT STUDIES; CREATININE; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; GLOMERULAR FILTRATION RATE; HUMANS; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SINGAPORE;

EID: 84866101912     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2602-5     Document Type: Article

References (6)

1. Yasuda K, Miyake K, Horikawa Y et al (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1092-1097
2. Unoki H, Takahashi A, Kawaguchi T et al (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40:1098-1102
3. Ohshige T, Tanaka Y, Araki S et al (2010) A single nucleotide polymorphism in KCNQ1 is associated with susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes Care 33:842-846
4. National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39:S1-S266
5. Ohnishi Y, Tabaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y (2001) A high-throughput SNP typing system for genome-wide association studies. J Hum Genet 46:471-477
6. Lang F, Rehwald W (1992) Potassium channels in renal epithelial transport regulation. Physiol Rev 72:1-32