The atrial neural network as a substrate for atrial fibrillation

Journal of Interventional Cardiac Electrophysiology

Volumn 35, Issue 1, 2012, Pages 3-9

  Mao, Jun ^a   Scherlag, Benjamin J ^d   Liu, Yu ^b   Fan, Youqi ^c   Varma, Vandana ^d   Stavrakis, Stavros ^d   Po, Sunny S ^d  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Acetylcholine; Atrial fibrillation; Atropine; Autonomic ganglia

Indexed keywords

ACETYLCHOLINE; ATROPINE; PENTOBARBITAL;

ABLATION THERAPY; ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTICLE; ATRIAL NEURAL NETWORK; AUTONOMIC GANGLION; CONTROLLED STUDY; DISEASE DURATION; DOG; DRUG EFFICACY; ELECTROSTIMULATION; GANGLIONATED PLEXI; HEART ATRIUM; HEART ATRIUM APPENDAGE; HEART ATRIUM FIBRILLATION; HEART EXCITATION; HEART FUNCTION; HEART LEFT ATRIUM; HEART RATE; HEART RIGHT ATRIUM; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; ATRIAL FIBRILLATION; ATROPINE; DISEASE MODELS, ANIMAL; DOGS; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; HEART ATRIA; HEART CONDUCTION SYSTEM; NERVE NET;

EID: 84866096193     PISSN: 1383875X     EISSN: 15728595     Source Type: Journal    
DOI: 10.1007/s10840-012-9692-3     Document Type: Article

References (41)

1. Armour, J. A., Murphy, D. A., Yuan, B. X., MacDonald, S., & Hopkins, D. A. (1997). Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anatomical Record, 247, 289-298.
2. Yuan, B. X., Ardell, J. L., Hopkins, D. A., Losier, A. M., & Armour, J. A. (1994). Gross and microscopic anatomy of the canine intrinsic cardiac nervous system. Anatomical Record, 239, 75-87.
3. Pauza, D. H., Skripka, V., Pauziene, N., & Stropus, R. (1999). Anatomical study of the neural ganglionated plexus in the canine right atrium: implication for selective denervation and electrophysiology of the sinoatrial node in the dog. Anatomical Record, 255, 271-294.
4. Hou, Y. L., Scherlag, B. J., Lin, J., Zhou, J., Song, J., Zhang, Y., et al. (2007). Interactive atrial neural network: determining the connection between ganglionated plexi. Heart Rhythm, 4, 56-63.
5. Nakagawa, H., Yokoyama, K., Scherlag, B. J., Katari, V., Aoyama, H., Foresti, S., et al. (2008). Ablation of autonomic ganglia. In H. Calkins, P. Jais, & J. S. Steinberg (Eds.), A practical approach to catheter ablation of atrial fibrillation. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. Chap.14 (see Figure 14.3).
6. Po, S. S., Scherlag, B. J., Yamanashi, W. S., Edwards, J., Zhou, J., Wu, R., et al. (2006). Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm, 3, 201-208.
7. Scherlag, B. J., Hou, Y. L., Lin, J., Lu, Z., Zacharias, S., Dasari, T. W., et al. (2008). An acute model for atrial fibrillation arising from a peripheral atrial site: evidence for primary and secondary triggers. Journal of Cardiovascular Electrophysiology, 5, 518-527.
8. Lu, Z., Scherlag, B. J., Lin, J., Niu, G., Fung, K. M., Zhao, L., et al. (2008). Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing. Circulation. Arrhythmia and Electrophysiology, 1, 184-192.
9. Jaïs, P., Haïssaguerre, M., Shah, D. C., Chouairi, S., Gencel, L., Hocini, M., et al. (1997). A focal source of atrial fibrillation treated by discrete radiofrequency ablation. Circulation, 95, 572-576.
10. Haïssaguerre, M., Jaïs, P., Shah, D. C., Gencel, L., Pradeau, V., Garrigues, S., et al. (1996). Right and left atrial radiofrequency catheter therapy of paroxysmal atrial fibrillation. Journal of Cardiovascular Electrophysiology, 7, 1132-1144.
11. Nademanee, K., Schwab, M. C., Kosar, E., et al. (2004). A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate. Journal of the American College of Cardiology, 43, 2044-2053.
12. Ardell, J. L. (1994). Structure and function of the mammalian intrinsic cardiac neurons. In J. A. Armour & J. L. Ardell (Eds.), Neurocardiology. New York: Oxford University Press. Chap 5.
13. Randall, D. C., Brown, D. R., McGuirt, A. S., Thompson, G. W., Armour, J. A., & Ardell, J. L. (2003). Interactions within the intrinsic autonomic nervous system contribute to chronotropic regulation. American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology, 285, R1066-R1075.
14. Hoff, H. E., & Geddes, L. A. (1955). Cholinergic factor in atrial fibrillation. Journal of Applied Physiology, 8, 177-192.
15. Henning, R. J., & Sawmiller, D. R. (2001). Vasoactive intestinal peptide: cardiovascular effects. Cardiovascular Research, 49, 27-37.
16. Xi, Y., Tomohiko, A., Wu, G., Samai, K., Li, S. F., Yuan, X., et al. (2009). Vasoactive intestinal polypeptide increased action potential spatiotemporal heterogeneity and vulnerability to atrial fibrillation. Heart Rhythm, 6, S233 (abstract).
17. Scherlag, B. J., Nakagawa, H., Jackman, W. M., Yamanashi, W. S., Patterson, E., Po, S., et al. (2005). Electrical stimulation to identify neural elements on the heart: their role in atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 13, 37-42.
18. Po, S. S., Nakagawa, H., & Jackman, W. M. (2009). Localization of left atrial ganglionated plexi in patients with AF. Journal of Cardiovascular Electrophysiology, 84, 245-252.
19. Katritsis, D. G., Giazitzoglou, E., Zografos, T., Pokushalov, E., Po, S. S., & Camm, A. J. (2010). Rapid pulmonary vein isolation combined with autonomic ganglia modification: a randomized study. Heart Rhythm, 8, 672-678.
20. Kaijser, L., & Sachs, C. (1985). Autonomic cardiovascular responses in old age. Clinical Physiology and Functional Imaging, 5, 347-357.
21. Nakagawa, H., Yokoyama, K., Wu, R., Po, S. S., Lockwood, D. J., Beckman, K. J., et al. (2006). Comparison of areas of fractionated atrial potentials and location of autonomic ganglionated plexi among patients with paroxysmal, persistent and permanent atrial fibrillation. Heart Rhythm, 3, S6 (abstract).
22. Pappone, C., Santinelli, V., Manguso, F., Vicedomini, G., Gugliotta, F., Augello, G., et al. (2004). Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation, 109, 327-334.
23. Nakagawa, H., Hayan, G., Scherlag, B. J., Ikeda, A., Lazzara, R., & Jackman, W. M. (2009). Elimination of pulmonary vein firing and fractionated atrial potentials by ablation of autonomic ganglionated plexi. Circulation, 120, S658 (abstract).
24. Morillo, C. A., Klein, G. J., Jones, G. L., & Guiradon, C. M. (1995). Chronic rapid atrial pacing: Structural, functional and a new model of sustained atrial fibrillation. Circulation, 91, 1588-1595.
25. Wijffels, M. C., Kirchhof, C. J., Dorland, R., Power, J., & Allessie, M. A. (1997). Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation. Circulation, 18(96), 3710-3720.
26. Alessi, R., Nusynowitz, M., Abildscov, J. A., & Moe, G. K. (1958). Non-uniform distribution of vagal effects on atrial refractory period. American Journal of Physiology, 194, 406-410.
27. Allessie, M., Lammers, W. J. E. P., Bonke, F. I. M., & Hollen, J. (1985). Experimental evaluation of Moe's multiple wavelet hypothesis of atrial fibrillation. In D. P. Zipes & Jalife (Eds.), Cardiac electrophysiology and arrhythmias (pp. 265-275). New York: Grune and Stratton.
28. Yamabe, H., Morihisa, K., Koyama, J., Enomoto, K., Kanazawa, H., & Ogawa, H. (2011). Analysis of the mechanisms initiating random wave propagation at the onset of atrial fibrillation using non-contact mapping: role of complex fractionated electrogram region. Heart Rhythm, 8, 1228-1236.
29. Di Biase, L., Burkhardt, J. D., Mohanty, P., Sanchez, J., Mohanty, S., Horton, R., et al. (2010). Left atrial appendage: an under recognized trigger site of atrial fibrillation. Circulation, 122, 109-118.
30. Patterson, E., Po, S. S., Scherlag, B. J., & Lazzara, R. (2005). Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm, 2, 624-631.
31. Lemola, K., Chartier, D., Yeh, Y. H., Dubuc, M., Cartier, R., Armour, J. A., et al. (2008). Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation, 117, 470-477.
32. Lin, J., Scherlag, B. J., Lu, Z., Zhang, Y., Liu, S., Patterson, E., et al. (2008). Inducibility of atrial and ventricular arrhythmias along the ligament of Marshall: role of autonomic factors. Journal of Cardiovascular Electrophysiology, 19, 955-962.
33. Lu, Z., Scherlag, B. J., Niu, G., Lin, J., Fung, K. M., Zhao, L., et al. (2010). Functional properties of the superior vena cava (SVC)-aorta ganglionated plexus: evidence suggesting an autonomic basis for rapid SVC firing. Journal of Cardiovascular Electrophysiology, 21, 1392-1399.
34. Platt, M., Mandapati, R., Scherlag, B. J., Yamanashi, W. S., Nakagawa, H., Lazzara, R., et al. (2004). Limiting the number and extent of radiofrequency applications to terminate atrial fibrillation and subsequently prevent its inducibility. Heart Rhythm, 1, S-11 (abstract).
35. Scanavacca, M., Pisani, C. F., Hachul, D., Lara, S., Hardy, C., Darrieux, F., et al. (2006). Selective atrial vagal denervation guided by evoked vagal reflex to treat patients with paroxysmal atrial fibrillation. Circulation, 114, 876-885.
36. Danik, S., Neuzil, P., d'Avila, Malchano, Z. J., Kralovec, S., Ruskin, J. N., et al. (2008). Evaluation of catheter ablation of periatrial ganglionic plexi in patients with atrial fibrillation. The American Journal of Cardiology, 102, 578-583.
37. Moe, G. K., & Albildskov, J. A. (1959). Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. American Heart Journal, 58, 59-70.
38. Chou, C. C., Zhou, S., Tan, A. Y., Hayashi, H., Nihei, M., & Chen, P.-S. (2005). High density mapping of pulmonary veins and left atrium during ibutilide administration in a canine model of sustained atrial fibrillation. American Journal of Physiology, 289, H2704-H2713.
39. Niu, G., Scherlag, B. J., Lu, Z., Ghias, M., Zhang, Y., Patterson, E., et al. (2009). An acute experimental model demonstrating 2 different forms of sustained atrial tachyarrhythmias. Circulation. Arrhythmia and Electrophysiology, 2, 384-392.
40. Malcolme-Lawes, L., Phang, B. L., Whinnett, Z. I., Kojodjojo, P., Davies, W., Peters, N. S., et al. (2010). Ganglionated plexi stimulation produces vagally mediated local changes in atrial fibrillation cycle length. Heart Rhythm, 7, S40 (abstract).
41. Jiang, R. H., Jiang, C. Y., & Po, S. S. (2011). Regional ganglionated plexus ablation eliminated rapid firing in an electrically isolated pulmonary vein. PACE (in press)