Neuromuscular blocking agents in patients with acute respiratory distress syndrome: A summary of the current evidence from three randomized controlled trials

Annals of Intensive Care

Volumn 2, Issue 1, 2012, Pages

  Neto, Ary Serpa ^a   Pereira, Victor Galvão Moura ^a   Espósito, Daniel Crepaldi ^a   Damasceno, Maria Cecília Toledo ^a   Schultz, Marcus J ^b  

^a FACULDADE DE MEDICINA DO ABC   (Brazil)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

ARDS; Meta analysis; Neuromuscular blocking agents; Review

Indexed keywords

ATRACURIUM; NEUROMUSCULAR BLOCKING AGENT; PLACEBO;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ARTERIAL OXYGEN TENSION; ARTIFICIAL VENTILATION; BAROTRAUMA; HUMAN; LUNG GAS EXCHANGE; MEDLINE; META ANALYSIS; MORTALITY; NEUROMUSCULAR BLOCKING; NEUROMUSCULAR DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW;

EID: 84866087824     PISSN: None     EISSN: 21105820     Source Type: Journal    
DOI: 10.1186/2110-5820-2-33     Document Type: Review

References (12)

1. Villar J, Blanco J, Añón JM, Santos-Bouza A, Blanch L, Ambrós A, Gandía F, Carriedo D, Mosteiro F, Basaldúa S, Fernández RL, Kacmarek RM, ALIEN Network: The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 2011, 37:1932-1941.
2. Pipeling MR, Fan E: Therapies for refractory hypoxemia in acute respiratory distress syndrome. JAMA 2010, 304:2521-2527.
3. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guérin C, Prat G, Morange S, Roch A, ACURASYS Study Investigators: Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010, 363:1107-1116.
4. Murray MJ, Cowen J, DeBlock H, Erstad B, Gray AW Jr, Tescher AN, McGee WT, Prielipp RC, Susla G, Jacobi J, Nasraway SA Jr, Lumb PD: Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), American Society of Health-System Pharmacists, American College of Chest Physicians: Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient. Crit Care Med 2002, 30:142-156.
5. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824.
6. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Schünemann HJ: GRADE: what is "quality of evidence" and why is it important to clinicians? BMJ 2008, 336:995-998.
7. Gainnier M, Roch A, Forel JM, Thirion X, Arnal JM, Donati S, Papazian L: Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med 2004, 32:113-119.
8. Forel JM, Roch A, Marin V, Michelet P, Demory D, Blache JL, Perrin G, Gainnier M, Bongrand P, Papazian L: Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome. Crit Care Med 2006, 34:2749-2757.
9. Laffey JG, Tanaka M, Engelberts D, Luo X, Yuan S, Tanswell AK, Post M, Lindsay T, Kavanagh BP: Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000, 162:2287-2294.
10. Hansen-Flaschen J, Cowen J, Raps EC: Neuromuscular blockade in the intensive care unit: More than we bargained for. Am Rev Respir Dis 1993, 147:234-236.
11. Gusmão D: Neuromuscular blockers and ARDS. N Engl J Med 2010, 363:2562-2563.
12. Sharshar T, Bastuji-Garin S, Stevens RD, Durand MC, Malissin I, Rodriguez P, Cerf C, Outin H, De Jonghe B, Groupe de Réflexion et d'Etude des Neuromyopathies En Réanimation: Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality. Crit Care Med 2009, 37:3047-3053