A one-pot umpolung method for preparation of α-aryl nitriles from α-chloro aldoximes via organocuprate additions to transient nitrosoalkenes

Synthesis (Germany)

Volumn 44, Issue 18, 2012, Pages 2933-2937

  Sengupta, Ritobroto ^a   Weinreb, Steven M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

aldehydes; arylation; cuprates; nitriles; nucleophilic addition

Indexed keywords

ALDOXIMES; ARYL NITRILE; ARYLATIONS; CONJUGATE ADDITION; CUPRATES; DICYCLOHEXYLCARBODIIMIDE; IN-SITU; NITRILES; NUCLEOPHILIC ADDITIONS; ONE POT; ONE-POT PROTOCOL; ORGANOCUPRATE; UMPOLUNG;

ADDITION REACTIONS; ALDEHYDES; COPPER COMPOUNDS;

CYANIDES;

2 (4 CHLOROPHENYL) 3 METHYLBUTANENITRILE; 2 (4 METHOXYPHENYL) 3 METHYLBUTANENITRILE; 2 [4 (DIMETHYLAMINO)PHENYL] 3 METHYLBUTANENITRILE; 2 CHLORO 3 METHYLBUTANAL OXIME; 2 CHLORO 3 PHENYLPROPANAL OXIME; 2 CHLORO 3,3 DIMETHYLBUTANAL OXIME; 2 CHLOROACETALDEHYDE OXIME; 2 CHLOROBUTANAL OXIME; 2 CHLOROPROPANAL OXIME; 3 METHYL 2 PHENYLBUTANENITRILE; 4 TERT BUTYL 1 CHLOROCYCLOHEXANECARBALDEHYDE OXIME; ALDOXIME; ALPHA ARYLNITRILE; ALPHA CHLOROALDOXIME DERIVATIVE; NITRILE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; STEREOCHEMISTRY; SYNTHESIS;

EID: 84866070466     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1316984     Document Type: Article

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