Elimination of α-Gal xenoreactive epitope: α-galactosidase treatment of porcine heart valves

Journal of Heart Valve Disease

Volumn 21, Issue 3, 2012, Pages 387-397

  Choi, Sun Young ^a   Jeong, Hee Jin ^b   Lim, Hong Gook ^a   Park, Seong Sik ^c   Kim, Soo Hwan ^a   Kim, Yong Jin ^a  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Dankook University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSIDASE; COLLAGEN FIBER; EPITOPE; RECOMBINANT ALPHA GALACTOSIDASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; DIAMINOBENZIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA VALVE; ARTICLE; BACTEROIDES THETAIOTAOMICRON; BIOMECHANICS; CONTROLLED STUDY; HEART VALVE; INCUBATION TIME; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PERICARDIUM; PH; PRIORITY JOURNAL; PULMONARY VALVE; THERAPY EFFECT; TRANSMISSION ELECTRON MICROSCOPY; XENOGRAFT; ANIMAL; BIOPROSTHESIS; DRUG EFFECT; GRAFT REJECTION; HEART VALVE PROSTHESIS; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGY; MASS SPECTROMETRY; METHODOLOGY; PEPTIDE MAPPING; PROSTHESIS FAILURE; SWINE;

3,3'-DIAMINOBENZIDINE; ALPHA-GALACTOSIDASE; ANIMALS; AORTIC VALVE; BIOMECHANICS; BIOPROSTHESIS; EPITOPES; GRAFT REJECTION; HEART VALVE PROSTHESIS; HUMANS; MASS SPECTROMETRY; MODELS, ANIMAL; PEPTIDE MAPPING; PERICARDIUM; PROSTHESIS FAILURE; PULMONARY VALVE; SUS SCROFA; SWINE; TRANSPLANTATION IMMUNOLOGY;

EID: 84866037252     PISSN: 09668519     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Cooke SP, Pearson JD, Savage CO. Human IgG xenoreactive antibodies mediate damage to porcine endothelial cells in vitro by both humoral and cellular mechanisms. Transpl Immunol 1997;5:39-44
2. Lin SS, Kooyman DL, Daniels LJ, et al. The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl Immunol 1997;5:212-218
3. Good AH, Cooper DK, Malcolm AJ, et al. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in humans. Transplant Proc 1992;24:559-562
4. Oriol R, Ye Y, Koren E, Cooper DK. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993;56:1433-1442
5. Sandrin MS, Vaughan HA, Dabkowski PL, McKenzie IF. Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes. Proc Natl Acad Sci USA 1993;90:11391-11395
6. Cooper DK, Koren E, Oriol R. Oligosaccharides and discordant xenotransplantation. Immunol Rev 1994;141:31-58
7. Sandrin MS, McKenzie IF. Gal alpha (1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies. Immunol Rev 1994;141:169-190
8. Galili U. Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: A major obstacle for xenotransplantation in humans. Immunol Today 1993;14:480-482
9. Simionescu DT. Prevention of calcification in bioprosthetic heart valves: Challenges and perspectives. Expert Opin Biol Ther 2004;4:1971-1985
10. Konakci KZ, Bohle B, Blumer R, et al. Alpha-Gal on bioprostheses: Xenograft immune response in cardiac surgery. Eur J Clin Invest 2005;35:17-23
11. Villa ML, De Biasi S, Pilotto F. Residual heteroantigenicity of glutaraldehyde-treated porcine cardiac valves. Tissue Antigens 1980;16:62-69
12. Schoen FJ. Editorial: Are immune mechanisms important in tissue heart valve failure? A debate. J Heart Valve Dis 2001;10:458-459
13. Vyavahare N, Hirsch D, Lerner E, et al. Prevention of bioprosthetic heart valve calcification by ethanol preincubation. Efficacy and mechanisms. Circulation 1997;95:479-488
14. Park CS, Park SS, Choi SY, Yoon SH, Kim WH, Kim YJ. Anti alpha-gal immune response following porcine bioprosthesis implantation in children. J Heart Valve Dis 2010;19:124-130
15. Ueda Y, Torrianni MW, Coppin CM, Iwai S, Sawa Y, Matsuda H. Antigen clearing from porcine heart valves with preservation of structural integrity. Int J Artif Organs 2006;29:781-789
16. Griffiths LG, Choe LH, Reardon KF, Dow SW, Christopher Orton E. Immunoproteomic identification of bovine pericardium xenoantigens. Biomaterials 2008;29:3514-3520
17. Kim YG, Gil GC, Harvey DJ, Kim BG. Structural analysis of alpha-Gal and new non-Gal carbohydrate epitopes from specific pathogen-free miniature pig kidney. Proteomics 2008;8:2596-2610
18. Ciucanu I, Costello CE. Elimination of oxidative degradation during the per-O-methylation of carbohydrates. J Am Chem Soc 2003;125:16213-16219
19. Stacchino C, Bona G, Bonetti F, Rinaldi S, Della Ciana L, Grignani A. Detoxification process for glutaraldehyde- treated bovine pericardium: Biological, chemical and mechanical characterization. J Heart Valve Dis 1998;7:190-194
20. Koma M, Miyagawa S, Honke K, et al. Reduction of the major xenoantigen on glycosphingolipids of swine endothelial cells by various glycosyltransferases. Glycobiology 2000;10:745-751
21. Chen RH, Mitchell RN, Kadner A, Adams DH. Differential galactose alpha(1,3) galactose expression by porcine cardiac vascular endothelium. Xenotransplantation 1999;6:169-172
22. Kin T, Nakajima Y, Aomatsu Y, et al. Humoral human xenoreactivity against isolated pig pancreatic islets. Surg Today 2000;30:821-826
23. Gabbay S, Kadam P, Factor S, Cheung TK. Do heart valve bioprostheses degenerate for metabolic or mechanical reasons? J Thorac Cardiovasc Surg 1988;95:208-215
24. Manji RA, Zhu LF, Nijjar NK, et al. Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection. Circulation 2006;114:318-327
25. Kasimir MT, Rieder E, Seebacher G, Wolner E, Weigel G, Simon P. Presence and elimination of the xenoantigen gal (alpha1,3) gal in tissue-engineered heart valves. Tissue Eng 2005;11:1274-1280
26. Carpentier A, Lemaigre G, Robert L, Carpentier S, Dubost C. Biological factors affecting long-term results of valvular heterografts. J Thorac Cardiovasc Surg 1969;58:467-483
27. Farivar RS, Filsoufi F, Adams DH. Mechanisms of Gal(alpha)1-3Gal(beta)1- 4GlcNAc-R (alphaGal) expression on porcine valve endothelial cells. J Thorac Cardiovasc Surg 2003;125:306-314
28. Kozlowski T, Monroy R, Xu Y, et al. Anti- Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction. Transplantation 1998;66:176-182
29. Cooper DK, Thall AD. Xenoantigens and xenoantibodies: Their modification. World J Surg 1997;21:901-906
30. Luo Y, Wen J, Luo C, Cummings RD, Cooper DK. Pig xenogeneic antigen modification with green coffee bean alpha-galactosidase. Xenotransplantation 1999;6:238-248
31. .Watier H, Guillaumin JM, Piller F, et al. Removal of terminal alpha-galactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity but persistence of IgG1- mediated antibody-dependent cell-mediated cytotoxicity. Transplantation 1996;62:105-113
32. Jang-Lee J, North SJ, Sutton-Smith M, et al. Glycomic profiling of cells and tissues by mass spectrometry: Fingerprinting and sequencing methodologies. Methods Enzymol 2006;415:59-86
33. Parry S, Ledger V, Tissot B, et al. Integrated mass spectrometric strategy for characterizing the glycans from glycosphingolipids and glycoproteins: Direct identification of sialyl Le(x) in mice. Glycobiology 2007;17:646-654
34. Roth J. Protein N-glycosylation along the secretory pathway: Relationship to organelle topography and function, protein quality control, and cell interactions. Chem Rev 2002;102:285-303
35. Yeh P, Ezzelarab M, Bovin N, et al. Investigation of potential carbohydrate antigen targets for human and baboon antibodies. Xenotransplantation 2010;17:197-206