Hydrophilic polymers enhance early functional outcomes after nerve autografting

Journal of Surgical Research

Volumn 177, Issue 2, 2012, Pages 392-400

  Sexton, Kevin W ^a   Pollins, Alonda C ^a   Cardwell, Nancy L ^a   Del Corral, Gabriel A ^a   Bittner, George D ^b   Shack, R Bruce ^a   Nanney, Lillian B ^a   Thayer, Wesley P ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Axonal fusion; Axonal repair; Hydrophilic polymers; Methylene blue; Nerve fusion; Nerve graft; Polyethylene glycol; Traumatic neuropathy

Indexed keywords

MACROGOL; METHYLENE BLUE; POLYMER;

ACTION POTENTIAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; CONTROLLED STUDY; HISTOLOGY; HYDROPHILICITY; IMMUNOHISTOCHEMISTRY; MATERIALS; MICROSCOPY; MICROSURGERY; MORPHOLOGY; MOTOR ACTIVITY; NERVE GRAFT; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SCORING SYSTEM;

ACTION POTENTIALS; ANIMALS; AXONS; BEHAVIOR, ANIMAL; FEMALE; FOOT; NERVE REGENERATION; NERVE TRANSFER; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SCIATIC NEUROPATHY; SURFACE-ACTIVE AGENTS;

EID: 84866024495     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.03.049     Document Type: Article

References (45)

1. B. Neumann, K.C.Q. Nguyen, and D.H. Hall Axonal regeneration proceeds through specific axonal fusion in transected C. elegans neurons Dev Dyn 240 2011 1365
2. S.A. Deriemer, E.J. Elliott, and E.R. Macagno Morphological evidence that regenerating axons can fuse with severed axon segments Brain Res 272 1983 157
3. A.B. Lore, J.A. Hubbell, and D.S. Bobb Rapid induction of functional and morphological continuity between severed ends of mammalian or earthworm myelinated axons J Neurosci 19 1999 2442
4. J.M. Britt, J.R. Kane, and C.S. Spaeth Polyethylene glycol rapidly restores axonal integrity and improves the rate of motor behavior recovery after sciatic nerve crush injury J Neurophysiol 104 2010 695
5. C. Spaeth, T. Robinson, and J. Fan Cellular mechanisms of plasmalemmal sealing and axonal repair by polyethylene glycol and methylene blue J Neurosci Res 2012 (in press)
6. G. Bittner, C. Keating, and J. Kane Rapid, effective and long-lasting behavioral recovery produced by microsutures, methylene blue and polyethylene glycol after complete cut of rat sciatic nerves J Neurosci Res 90 2012 967
7. G. Kohler, and C. Milstein Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 1975 495
8. Ramon Y, Cajal S. Degeneration & regeneration of the nervous system. May RM, trans., ed. New York: Hafner Publishing, 1928.
9. M.P. Nguyen, G.D. Bittner, and H.M. Fishman Critical interval of somal calcium transient after neurite transection determines B 104 cell survival J Neurosci Res 81 2005 805
10. T.L. Krause, and G.D. Bittner Rapid morphological fusion of severed myelinated axons by polyethylene glycol Proc Natl Acad Sci U S A 87 1990 1471
11. T. Marzullo, J. Britt, and R. Stavisky Cooling enhances in vitro survival and fusion-repair of severed axons taken from the peripheral and central nervous systems of rats Neurosci Lett 327 2002 9
12. R. Stavisky, J. Britt, and A. Zuzek Melatonin enhances the in vitro and in vivo repair of severed rat sciatic axons Neurosci Lett 376 2005 98
13. B.K. Kwon, L.H. Sekhon, and M.G. Fehlings Emerging repair, regeneration, and translational research advances for spinal cord injury Spine 35 Suppl 2010 S263
14. T.L. Krause, H.M. Fishman, and G.D. Bittner Axolemmal and septal conduction in the impedance of the earthworm medial giant nerve fiber Biophys J 67 1994 692
15. C.S. Spaeth, E.A. Boydston, and L.R. Figard A model for sealing plasmalemmal damage in neurons and other eukaryotic cells J Neurosci 30 2010 15790
16. S. Yoo, M.P. Nguyen, and M. Fukuda Plasmalemmal sealing of transected mammalian neurites is a gradual process mediated by Ca(2+)-regulated proteins J Neurosci Res 74 2003 541
17. S.K. Lee, and S.W. Wolfe Peripheral nerve injury and repair J Am Acad Orthop Surg 8 2000 243
18. T.G. Kantor Ketoprofen: A review of its pharmacologic and clinical properties Pharmacotherapy 6 1986 93
19. J. Šedý, L. Urdzíková, and P. Jendelová Methods for behavioral testing of spinal cord injured rats Neurosci Biobehav Rev 32 2008 550
20. L. de Medinaceli, W.J. Freed, and R.J. Wyatt An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks Exp Neurol 77 1982 634
21. P. Dinh, A. Hazel, and W. Palispis Functional assessment after sciatic nerve injury in a rat model Microsurgery 29 2009 644
22. C. Nichols, T. Myckatyn, and S. Rickman Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat Behav Brain Res 163 2005 143
23. A. Bozkurt, R. Deumens, and J. Scheffel CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury J Neurosci Meth 173 2008 91
24. J.R. Bain, S.E. Mackinnon, and D.A. Hunter Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat Plast Reconstr Surg 83 1989 129
25. Y. Kawasaki, K. Yoshimura, and K. Harii Identification of myelinated motor and sensory axons in a regenerating mixed nerve J Hand Surg 25A 2000 104
26. D.A. Riley, J.R. Sanger, and H.S. Matloub Identifying motor and sensory myelinated axons in rabbit peripheral nerves by histochemical staining for carbonic anhydrase and cholinesterase activities Brain Res 453 1988 79
27. W. Cammer, and F.A. Tansey Immunocytochemical localization of carbonic anhydrase in myelinated fibers in peripheral nerves of rat and mouse J Histochem Cytochem 35 1987 865
28. J. Badia, A. Pascual-Font, and M. Vivó Topographical distribution of motor fascicles in the sciatic-tibial nerve of the rat Muscle Nerve 42 2010 192
29. N. Lago, and X. Navarro Correlation between target reinnervation and distribution of motor axons in the injured rat sciatic nerve J Neurotrauma 23 2006 227
30. M.D. Abràmoff, P.J. Magalhães, and S.J. Ram Image processing with ImageJ Biophotonics Int 11 2004 36
31. N. Marina, N.D. Bull, and K.R. Martin A semiautomated targeted sampling method to assess optic nerve axonal loss in a rat model of glaucoma Nat Protoc 5 2010 1642
32. R. Miledi, and C.R. Slater On the degeneration of rat neuromuscular junctions after nerve section J Physiol 207 1970 507
33. E. Lunn, M. Brown, and V. Perry The pattern of axonal degeneration in the peripheral nervous-system varies with different types of lesion Neuroscience 35 1990 157
34. R.W. Gilliatt, and R.J. Hjorth Nerve conduction during Wallerian degeneration in the baboon Neurol Neurosurg Psychiatry 35 1972 335
35. V. Chaudhry, and D.R. Cornblath Wallerian degeneration in human nerves: Serial electrophysiological studies Muscle Nerve 15 1992 687
36. A.H. Koeppen Wallerian degeneration: History and clinical significance J Neurol Sci 220 2004 115
37. S.W. Wolfe, R.N. Hotchkiss, and W.C. Pederson Green's operative hand surgery 2011 Churchill Livingstone New York 5
38. J.R. Kang, D.P. Zamorano, and R. Gupta Limb salvage with major nerve injury: current management and future directions J Am Acad Orthop Surg 19 Suppl 2011 S28
39. W.W. Campbell Evaluation and management of peripheral nerve injury Clin Neurophysiol 119 2008 1951
40. S. Stanec, I. Tonković, and Z. Stanec Treatment of upper limb nerve war injuries associated with vascular trauma Injury 28 1997 463
41. J. Glass, D. Culver, and A. Levey Very early activation of m-calpain in peripheral nerve during Wallerian degeneration J Neurol Sci 196 2002 9
42. A. Schiaveto de Souza, C.A. da Silva, and E.A. Del Bel Methodological evaluation to analyze functional recovery after sciatic nerve injury J Neurotrauma 21 2004 627
43. P.J. Evans, J.R. Bain, and S.E. Mackinnon Selective reinnervation: a comparison of recovery following microsuture and conduit nerve repair Brain Res 559 1991 315
44. E. Eidelberg, D. Straehley, and R. Erspamer Relationship between residual hindlimb-assisted locomotion and surviving axons after incomplete spinal cord injuries Exp Neurol 56 1977 312
45. B.A. Kakulas A review of the neuropathology of human spinal cord injury with emphasis on special features J Spinal Cord Med 22 1999 119