Optimizing a photoallodepletion protocol for adoptive immunotherapy after haploidentical SCT

Bone Marrow Transplantation

Volumn 47, Issue 9, 2012, Pages 1196-1200

  Perruccio, K ^a   Topini, F ^a   Tosti, A ^a   Carotti, A ^a   Burchielli, E ^a   Ruggeri, L ^a   Mancusi, A ^a   Urbani, E ^a   Aversa, F ^a   Martelli, M F ^a   Velardi, A ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

adoptive immunotherapy; haploidentical SCT; limitingdilution assay; photodynamic purging; T cell alloreactivity; T cell frequency

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; THYMIDINE; TRITIUM;

ADOPTIVE IMMUNOTHERAPY; ALLOIMMUNITY; ARTICLE; CELLULAR IMMUNITY; CLINICAL PROTOCOL; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; LYMPHOCYTE PRESERVATION; LYMPHOCYTE PROLIFERATION; PHOTODYNAMICS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; STEM CELL TRANSPLANTATION; T LYMPHOCYTE;

COHORT STUDIES; EPITOPES, T-LYMPHOCYTE; HAPLOTYPES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOTHERAPY, ADOPTIVE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; PHOTOCHEMOTHERAPY; T-LYMPHOCYTES;

EID: 84866003128     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2011.237     Document Type: Article

References (21)

1. Aversa F, Tabilio A, Terenzi A, Velardi A, Falzetti F, Giannoni C et al. Successful engraftment of T-cell-depleted haploidentical 'three-loci' incompatibile transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 1994; 84: 3948-3955.
2. Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F et al. Treatment of high risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186-1193. (Pubitemid 28482127)
3. Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S et al. Full haplotypemismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol 2005; 23: 3447-3454.
4. Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T-cell regeneration after bone marrow transplantation: differenzial CD45 isoform expression on thymicderived versus thymic-independent progeny. Blood 1993; 82: 2585-2594. (Pubitemid 23304286)
5. Mackall CL, Fleisher TA, Brown MR, Andrich MP, Chen CC, Feuerstein IM et al. Age, thymopoiesis, and CD4+T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995; 332: 143-149.
6. Mackall CL, Hakim FT, Gress RE. T-cell regeneration. All repertoires are not created equal. Immunol Today 1997; 18: 245-251. (Pubitemid 27219620)
7. Heitger A, Neu N, Kern H, Panzer-Grumayer ER, Greinix H, Nachbaur D et al. Essential role of the thymus to reconstitute naive (CD45RA+) T-helper cells after human allogeneic bone marrow transplantation. Blood 1997; 90: 850-857. (Pubitemid 27299126)
8. Amrolia PJ, Muccioli-Casadei G, Huls H, Adams S, Durett A, Gee A et al. Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation. Blood 2006; 108: 1797-1808. (Pubitemid 44394986)
9. Andrè-Schmutz I, Le Deist F, Hacein-Bey-Abina S, Vitetta E, Schindler J, Chedeville G et al. Immune reconstitution without graft-versus-host disease after hematopoietic stem-cell transplantation: a phase I-II study. Lancet 2002; 360: 130-137. (Pubitemid 34786202)
10. Guimond M, Balassy A, Barrette M, Brochu S, Perreault C, Roy DC. P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells. Blood 2002; 100: 375-382. (Pubitemid 34761096)
11. Mielke S, Nunes R, Rezvani K, Fellows VS, Venne A, Solomon SR et al. A clinicalscale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigenpresenting cells and a TH9402-based photodepletion technique. Blood 2008; 111: 4392-4402.
12. Chen BJ, Cui X, Liu C, Chao NJ. Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood 2002; 99: 3083-3088. (Pubitemid 34525284)
13. Perruccio K, Topini F, Tosti A, Carotti A, Aloisi T, Aversa F et al. Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation. Blood Cell Mol Dis 2008; 40: 76-83. (Pubitemid 350192305)
14. Gao L, Bellantuono I, Elsasser A, Marley SB, Gordon MY, Goldman JM et al. Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood 2000; 95: 2198-2203. (Pubitemid 30167714)
15. Camera A, Villa MR, Rocco S, De Novellis T, Costantini S, Pezzullo L et al. Increased Ca125 serum levels in patients with advanced acute leukaemia with serosal involvement. Cancer 2000; 88: 75-78. (Pubitemid 30027681)
16. Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100: 1611-1618. (Pubitemid 34925136)
17. Roy DC, Cohen S, Busque L, Fish D, Kiss T, Lachance S et al. Phase I clinical study of donor lymphocyte infusion depleted of alloreactive T cells after haplotype mismatched myeloablative stem cell transplantation to limit infections and malignant relapse without causing GvHD. Blood 2006; 108: 11 (abstract 309).
18. Mielke S, Shenoy A, Fellows V, Rezvani K, Savani BP, Musse L et al. Selective allodepletion by TH9402-mediated photosensitization results in early full donor T cell reconstitution in the absence of high grade, acute GvHD and is associated with favorable outcome after HLA matched sibling SCT for hematologic malignancies. Blood 2008; 112: 11 (abstract 1168).
19. Roy DC, Lachance S, Kiss T, Cohen S, Busque L, Fish D et al. Alloreactive T-cell depleted donor lymphocyte infusions decrease infections without causing severe GvHD after haplotype mismatched stem cell transplantation. Bone Marrow Transplant 2009; 43(suppl 1) (abstract 104).
20. Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007; 8: 549-551.
21. Romani L, Zelante T, De Luca A, Fallarino F, Puccetti P. IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi. J Immunol 2008; 180: 5157-5162.