Safety and efficacy of using off-label bevacizumab versus mitomycin c to prevent bleb failure in a single-site phacotrabeculectomy by a randomized controlled clinical trial

Journal of Glaucoma

Volumn 21, Issue 7, 2012, Pages 450-459

  Sengupta, Sabyasachi ^a,b   Venkatesh, Rengaraj ^a,b   Ravindran, Ravilla D ^a,b  

^a ARAVIND EYE HOSPITAL   (India)

^b Post Graduate Institute of Dental Sciences   (India)

Author keywords

bevacizumab; mitomycin C; phacoemulsification; trabeculectomy

Indexed keywords

BEVACIZUMAB; CELLULOSE; LATANOPROST; LATOPROST; MITOMYCIN C; TIMOLET; TIMOLOL MALEATE; UNCLASSIFIED DRUG;

ADULT; ANTERIOR EYE CHAMBER DEPTH; AQUEOUS HUMOR FLOW; ARTICLE; BLEB FAILURE; CLINICAL ARTICLE; CLOSED ANGLE GLAUCOMA; CONJUNCTIVAL NECROSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FEMALE; FILTERING OPERATION; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MALE; NECROSIS; OFF LABEL DRUG USE; OPEN ANGLE GLAUCOMA; OUTCOME ASSESSMENT; PHACOTRABECULECTOMY; POSTOPERATIVE COMPLICATION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCAR FORMATION; SIDE EFFECT; SURGICAL SPONGE; TRABECULECTOMY; VISUAL ACUITY; WOUND HEALING;

AGED; ALKYLATING AGENTS; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; CATARACT; CHRONIC DISEASE; COMBINED MODALITY THERAPY; CONJUNCTIVA; FEMALE; GLAUCOMA, ANGLE-CLOSURE; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; MITOMYCIN; OFF-LABEL USE; PHACOEMULSIFICATION; PILOT PROJECTS; TONOMETRY, OCULAR; TRABECULECTOMY; TREATMENT FAILURE; TREATMENT OUTCOME; WOUND HEALING;

EID: 84865982631     PISSN: 10570829     EISSN: 1536481X     Source Type: Journal    
DOI: 10.1097/IJG.0b013e31821826b2     Document Type: Article

References (23)

1. Addicks EM, Quigley HA, Green WR. Histologic characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol. 1983;101:795-798.
2. Hitchings RA, Grierson I. Clinicopathological correlation in eyes with failed fistulizing surgery. Trans Ophthalmol Soc UK. 1983;103:84-88.
3. Parrish R, Minckler D. "Late endophthalmitis"-filtering surgery time bomb? [Editorial]. Ophthalmology. 1996;103: 1167-1168.
4. The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 7 the relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429-440.
5. Cantor LB, Mantravadi A, WuDunn D, et al. Morphologic classification of filtering blebs after glaucoma filtration surgery: the indiana bleb appearance grading scale. J Glaucoma. 2003; 12:266-271.
6. Murthy SK, Damji KF, Pan Y, et al. Trabeculectomy and phacotrabeculectomy, with mitomycin-C, show similar twoyear target IOP outcomes. Can J Ophthalmol. 2006;41:51-59.
7. Robbins SL, Cotran R. Tissue renewal and repair: regeneration, healing and fibrosis. In: Kumar V, Abbas AK, Fausto N. Pathologic Basis of Diseas. 7th ed. Philadelphia: Elsevier Saunders; 2006:107.
8. Fluorouracil Filtering Surgery Study Group. Fluorouracil Filtering Surgery Study one-year follow-up. Am J Ophthalmol. 1989;108:625-635.
9. Kitazawa Y, Kawase K, Matsushita H, et al. Trabeculectomy with mitomycin. A comparative study with fluorouracil. Arch Ophthalmol. 1991;109:1693-1698.
10. Wilkins M, Indar A, Wormald R. Intra-operative Mitomycin C for glaucoma surgery. Cochrane Database of Systematic Reviews. 2001;1:CD002897. DOI: 10.1002/14651858.CD002897.pub2.
11. Jampel HD, Pasquale LR, Dibernardo C. Hypotony maculopathy following trabeculectomy with mitomycin C. Arch Ophthalmol. 1992;110:1049-1050.
12. Khaw PT, Jones E, Mireskandari K, et al. Modulating wound healing after glaucoma surgery. Advances in techniques and treatments. Glaucoma Today. 2004;12-19. Online access at http://www.glaucomatoday.com/art/0704/gt0704- research.pdf.
13. CAT-152 0102 Trabeculectomy Study Group. A phase III study of subconjunctival human anti-transforming growth factor 2 monoclonal antibody (CAT-152) to prevent scarring after firsttime trabeculectomy. Ophthalmology. 2007;114:1822-1830.
14. Jampel HD, Moon J. The effect of paclitaxel powder on glaucoma filtration surgery in rabbits. J Glaucoma. 1998;7:170-177.
15. Perkins TW, Faha B, Ni M, et al. Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery. Arch Ophthalmol. 2002;120:941-949.
16. Gillies M, Su T, Sarossy M, et al. Interferon-alpha 2b inhibits proliferation of human Tenon's capsule fibroblasts. Graefes Arch Clin Exp Ophthalmol. 1993;231:118-121.
17. Wong TT, Mead AL, Khaw PT. Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 2003; 44:1097-1103.
18. Saika S, Ooshima A, Yamanaka O, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996;234(suppl 1):214-222.
19. Bates DO, Jones RP. The role of vascular endothelial growth factor in wound healing. Int J Low Extrem Wounds. 2003;2: 107-120.
20. Ferrara N, Houck KA, Jakeman LB, et al. The vascular endothelial growth factor family of polypeptides. J Cell Biochem. 1991;47:211-218.
21. Memarzadeh F, Varma R, Lin LT, et al. Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit. Invest Ophthmol Vis Sci. 2009;50: 3233-3237.
22. Grewal DS, Jain R, Kumar H, et al. Evaluation of subconjunctival bevacizumab as an adjunct to trabeculectomy. A Pilot Study. Ophthalmology. 2008;115:2141-2145.e2.
23. Coote MA, Jonathan RB, Queena Q, et al. Vascular changes after intra-bleb injection of bevacizumab. J Glaucoma. 2008;17:517-518.